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Topic Review
Multifaceted Role of Golgi Apparatus
Functioning as the cellular “sorting hub”, the Golgi apparatus is indispensable in protein categorization and adjustments crucial to the dynamic equilibrium of neuronal structure, function, and synaptic adaptability. The Golgi apparatus is not only pivotal in protein categorization and alterations but also stands out as a central orchestrator of neuronal maturation. 
  • 353
  • 26 Sep 2023
Topic Review
Post-Kidney Transplant Measures to Prevent Rejection
With increasing knowledge of immunologic factors and with the advent of potent immunosuppressive agents, the last several decades have seen significantly improved allograft survival. Today, median graft survival ranges from 11.7 years in deceased donor kidney transplants up to 19.2 years in living donor kidney transplants. However, despite overall improved short to medium-term allograft survival, long-term allograft outcomes remain unsatisfactory.
  • 156
  • 26 Sep 2023
Topic Review
Urolithins
The impact of host–microbiome interactions on cognitive health and disease has received increasing attention. Microbial-derived metabolites produced in the gut are one of crucial mechanisms of the gut–brain axis interaction, showing attractive perspectives. Urolithins (Uros) are gut microbial-derived metabolites of ellagitannins and ellagic acid, whose biotransformation varies considerably between individuals and decreases greatly with age.
  • 171
  • 25 Sep 2023
Topic Review
Otomycosis
Otomycosis (OM) is a superficial fungal infection of the external auditory canal (EAC) with a worldwide prevalence ranging from 9% to 30%. Commonly, otomycoses are caused by Aspergillus (A.) niger complex and Candida spp. Other causative agents are yeasts of the genera Cryptococcus spp., Rhodotorula spp., Geotrichum candidum, dermatophytes (Trichophyton mentagrophytes), and non-dermatophytes molds (Fusarium spp., Penicillium spp., Mucorales fungi). 
  • 367
  • 25 Sep 2023
Topic Review
NF-κB Pathway Inhibitors in Alzheimer’s Disease Treatment
The NF-κB family is a group of transcription factors that play a pivotal role in regulating various biological processes, including immune responses, inflammation, cell survival, and cellular differentiation. The involvement of the NF-κB pathway in immune system responses, inflammation, oxidative stress, and neuronal survival highlights its significance in Alzheimer’s disease (AD) progression.
  • 220
  • 25 Sep 2023
Topic Review
Bioelectrical Impedance Analysis for Pregnant
Pregnancy is a time of significant changes occurring in the composition of a woman’s body in order to provide support for the growth and development of the fetus. Bioelectrical impedance analysis (BIA) is used to assess the body composition and hydration status. This technique represents a non-invasive, reliable, and fast clinical approach, which is well tolerated by patients. A segmental impedance measurement might be advantageous in pregnant women, particularly in late pregnancy.
  • 503
  • 25 Sep 2023
Topic Review
Pathogenesis of Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases encountered in obstetrics, and it is often associated with an increased risk of adverse pregnancy outcomes. GDM affects about 9–25% of pregnancies worldwide. The frequency of GDM increases with the age of a pregnant woman.
  • 392
  • 25 Sep 2023
Topic Review
PD-1/PD-L1 Inhibitors in Ovarian Cancer
Ovarian cancer is considered one of the most aggressive and deadliest gynecological malignancies worldwide. Unfortunately, the therapeutic methods that are considered the gold standard at this moment are associated with frequent recurrences. Survival in ovarian cancer is associated with the presence of a high number of intra tumor infiltrating lymphocytes (TILs). Therefore, immunomodulation is considered to have an important role in cancer treatment, and immune checkpoint inhibitors may be useful for restoring T cell-mediated antitumor immunity. PD-1 is a 50–55 kDa, 288 aa transmembrane glycoprotein that lacks the membrane-proximal cysteine residue required for homodimerization that is present in the structure of the other members of the CD28 family, thus rendering PD-1 monomeric, both in solution and on cell surface. The cytoplasmic domain presents two tyrosine residues, with the membrane-proximal one constituting an immunoreceptor tyrosine-based inhibitory motif (ITIM) and the second one constituting an immunoreceptor tyrosine-based switch motif (ITSM).
  • 302
  • 25 Sep 2023
Topic Review
Decoding Sepsis-Induced Disseminated Intravascular Coagulation
Disseminated intravascular coagulation (DIC) is a pathological disease that often manifests as a complication in patients with sepsis. Sepsis is a systemic inflammatory response caused by infection and is a major public health concern worldwide.
  • 469
  • 25 Sep 2023
Topic Review
EMT-Related lncRNAs in Ovarian Cancer
Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-coding RNAs (lncRNAs) have been also associated with several cancer-related mechanisms, including EMT. 
  • 178
  • 25 Sep 2023
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