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Topic Review
Nod-Like Receptor Pyrin Containing Protein 3 Inflammasome
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder, whose pathophysiology has been linked to the neuroinflammatory process. The increased activity of the Nod-like receptor pyrin containing protein 3 (NLRP3) inflammasome, an intracellular multiprotein complex, is intrinsically implicated in neuroinflammation by promoting the maturation and release of proinflammatory cytokines such as interleukin (IL)-1β and IL-18.
  • 330
  • 04 Jan 2023
Topic Review
General Classification of Spatial Profiling Technology
Spatial profiling technologies fill the gap left by the loss of spatial information in traditional single-cell sequencing, showing great application prospects. After just a few years of quick development, spatial profiling technologies have made great progress in resolution and simplicity.
  • 330
  • 19 Jul 2023
Topic Review
Microglia Phenomics in Alzheimer’s Disease
Phenomics, the complexity of microglia phenotypes and their related functions compels the continuous study of microglia in disease animal models to find druggable targets for neurodegenerative disorders. Activation of microglia was long considered detrimental for neuron survival, but it has become apparent that the real scenario of microglia morphofunctional diversity is far more complex.
  • 330
  • 14 Sep 2023
Topic Review
Islet β-Cell Death
The loss of β-cells is considered a key to the pathogenesis of both type 1 diabetes (T1D) and T2D.
  • 329
  • 31 Mar 2021
Topic Review
Redox Control in ALL
Acute lymphoblastic leukemia (ALL) is a hematological malignancy originating from B- or T-lymphoid progenitor cells. Recent studies have shown that redox dysregulation caused by overproduction of reactive oxygen species (ROS) has an important role in the development and progression of leukemia. The application of pro-oxidant therapy, which targets redox dysregulation, has achieved satisfactory results in alleviating the conditions of and improving the survival rate for patients with ALL. However, drug resistance and side effects are two major challenges that must be addressed in pro-oxidant therapy. Oxidative stress can activate a variety of antioxidant mechanisms to help leukemia cells escape the damage caused by pro-oxidant drugs and develop drug resistance. Hematopoietic stem cells (HSCs) are extremely sensitive to oxidative stress due to their low levels of differentiation, and the use of pro-oxidant drugs inevitably causes damage to HSCs and may even cause severe bone marrow suppression.
  • 329
  • 01 Jun 2021
Topic Review
Hypoxia-Associated Long Non-Coding RNAs in Breast Cancer
Breast cancer is the leading cause of cancer-related deaths in women worldwide. Long non-coding RNAs are newly described molecules that have extensive roles in breast cancer. Emerging reports have shown that there is a strong link between these RNAs and the hypoxic response of breast cancer cells, which may be an important factor for enhanced tumoral progression.
  • 329
  • 26 May 2022
Topic Review
Red Blood Cells and Their Adhesiveness in Disease
Red blood cells (RBCs) have been implicated in the progression of a wide range of disease states where their roles have been specifically linked to their adhesiveness. Such diseases include, inter alia, atherosclerosis, tumors (in terms of its growth suppression), polycythemia vera, central retinal occlusion and diabetes mellitus.
  • 328
  • 13 Jul 2023
Topic Review
Fibrinolytic Regulators in Systemic Sclerosis
The regulators of fibrinolysis contain plasminogen (Plg) a proenzyme, which is converted to the active serine protease plasmin, a main component of the fibrinolytic system, through the action of a tissue-type plasminogen activator (tPA) or urokinase-type plasminogen activator (uPA) and uPA receptor (uPAR).
  • 327
  • 29 Nov 2021
Topic Review
Role of Mitochondria in the Central Nervous System
Disruption of the synapses leads to a deterioration in the communication of nerve cells and decreased plasticity, which is associated with a loss of cognitive functions and neurodegeneration. Maintaining proper synaptic activity depends on the qualitative composition of mitochondria, because synaptic processes require sufficient energy supply and fine calcium regulation.
  • 327
  • 15 Mar 2023
Topic Review
Peroxiredoxins in Cancer Development
Peroxiredoxins (Prxs) are antioxidant enzymes with ubiquitous expression in human tissues. Because of their abundant expression in different cellular organelles and extraordinary sensitivity to H2O2, Prxs are among the first defenses against oxidative stress. Prxs undergo reversible oxidation to disulfides, and some family members perform chaperone or phospholipase functions upon further oxidation. Prxs are frequently upregulated in cancer cells and contribute to tumorigenesis and cancer progression. The roles of Prxs in the  development of major cancers are summarized below.
  • 327
  • 09 May 2023
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