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Topic Review
WormCNN
WormCNN is a specialized deep learning model designed for the analysis of images of the nematode Caenorhabditis elegans (C. elegans). This model utilizes convolutional neural network (CNN) architecture to classify and analyze the morphological features of C. elegans, providing valuable insights into various biological studies. 
  • 48
  • 10 Sep 2024
Topic Review
Cell Proteomic Footprinting
Cell proteomic footprinting (CPF) is a proteomic technology that involves the proteolytic cleavage of extracellular fragments of proteins and mass spectrometric measurement of the molecular masses of these fragments, the list of which (mass list) represents a cell footprint – a digital characteristic that is highly specific to cells. The cell footprint is of practical importance for the authentication of cell populations and subpopulations with desired useful properties, which is in demand in the development of cell-based pharmaceuticals, such as cellular cancer vaccines.
  • 146
  • 26 Aug 2024
Topic Review
16S rRNA Sequencing vs. Metagenome Sequencing
Microbiome research has revolutionized our understanding of complex microbial communities, and two pivotal techniques at the forefront of this exploration are 16S rRNA sequencing and metagenome sequencing.
  • 93
  • 01 Aug 2024
Topic Review Peer Reviewed
Arbuscular mycorrhizal Fungi as Inspiration for Sustainable Technology
This review illuminates established knowledge of root–arbuscular mycorrhizal fungi (AMF)–plant mutualism to study the uptake of phosphorus (P) as a critical element for plant nutrition. We focus on P cycling, underscoring the role of AMF in enhancing P acquisition and plant resilience in the rhizosphere. The role(s) of plant roots, root exudates, and biomolecules in relevant soil processes is emphasized in this manuscript. Enhancing P uptake efficiency through AMF interaction presents a promising avenue for sustainable agriculture, with future research opportunities focusing on understanding underlying mechanisms and developing innovative technologies as a need to transition from the use of AMF as a biofertilizer or as an inoculation alternative for seeds to being an inspiration for the development of technology adapted to different crops. This is important to promote responsible agricultural practices and improve crop yields. We provide definitions of key terms and concepts for one of the best-known natural sustainable phosphorus systems. This manuscript illuminates and aims to inspire technology development to overcome the challenge of plant nutrition under P scarcity conditions.
  • 461
  • 31 Jul 2024
Topic Review
Tumoroid
The term “tumoroid” means “tumor-like organoid”: tumoroids typically derive from primary tumors harvested from oncological patients and they can mimic human tumor microenvironment (TME); nowadays, they are considered a promising tool for cost-effective studies on novel anticancer drugs to be used in precision medicine in the field of oncology.
  • 4.6K
  • 18 Jun 2024
Topic Review
Bio-Dealcoholization of Wines
The link between viticulture and climate change has become more evident in recent years. The temperature rise has been a crucial factor in the early ripening of grapes, which has resulted in wines with imbalanced acidity, higher alcohol content, and higher pH values. Consumers are seeking high-quality and healthy products, and this trend has extended to wine consumption.
  • 630
  • 09 May 2024
Topic Review
Citric Acid Production by Yarrowia lipolytica Yeast
Citric acid (CA) and its derivatives, including salts and esters, are in high demand across various manufacturing sectors. The fungus Aspergillus niger is mainly used for the commercial production of CA, using sucrose and molasses as the primary carbon sources. Since the 1960s, researchers have been working intensively to introduce Yarrowia lipolytica yeast as an alternative to traditional fungal technology.
  • 307
  • 11 Apr 2024
Topic Review
Next-Generation Sequencing: Bioinputs for Agriculture Innovation
Bioinputs, a sustainable and potent alternative to chemical products used in agriculture, find a position of radical change with the advent of next-generation sequencing (NGS) techniques. These bioinputs, derived from microorganisms, assure the reduction of environmental impact and are able to increase food production. However, proper bioinput development will require the identification of these microorganisms at a level of detail, thereby ensuring a standardized approach. The assessment of potential risks to these microorganisms is thus critical for the safety and efficacy in use, while global collaboration can enable the establishment of standards to be adopted universally.
  • 409
  • 03 Apr 2024
Topic Review
Two-Phase Fermentation Systems for Microbial Production of Terpenes
Microbial cell factories, renowned for their economic and environmental benefits, have emerged as a key trend in academic and industrial areas, particularly in the fermentation of natural compounds. Among these, plant-derived terpenes stand out as a significant class of bioactive natural products. The large-scale production of such terpenes, exemplified by artemisinic acid—a crucial precursor to artemisinin—is now feasible through microbial cell factories. In the fermentation of terpenes, two-phase fermentation technology has been widely applied due to its unique advantages. It facilitates in situ product extraction or adsorption, effectively mitigating the detrimental impact of product accumulation on microbial cells, thereby significantly bolstering the efficiency of microbial production of plant-derived terpenes. 
  • 288
  • 02 Apr 2024
Topic Review
The Plethora of Microbes with Anti-Inflammatory Activities
Inflammation, which has important functions in human defense systems and in maintaining the dynamic homeostasis of the body, has become a major risk factor for the progression of many chronic diseases. Although the applied medical products alleviate the general status, they still exert adverse effects in the long term. For this reason, the solution should be sought in more harmless and affordable agents. Microorganisms offer a wide range of active substances with anti-inflammatory properties. They confer important advantages such as their renewable and inexhaustible nature.
  • 217
  • 21 Mar 2024
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