Topic Review
Zinc Complexes as Anticancer Agents
The search for anticancer metal-based drugs alternative to platinum derivatives could not exclude zinc derivatives due to the importance of this metal for the correct functioning of the human body. Zinc, the second most abundant trace element in the human body, is one of the most important micro-elements essential for human physiology. Its ubiquity in thousands of proteins and enzymes is related to its chemical features, in particular, its lack of redox activity and its ability to support different coordination geometries and to promote fast ligands exchange. Analogously to other trace elements, the impairment of its homeostasis can lead to various diseases and in some cases can be also related to cancer development. However, zinc complexes generally exert lower toxicity in comparison to other metal-based drugs and many zinc derivatives have been proposed as antitumor agents. Among them zinc complexes  comprising  N-donor ligands have been surveyed and analyzed. 
  • 572
  • 22 Dec 2020
Topic Review
Xylosma G. Forst. Genus
Xylosma G. Forst. is a genus of plants belonging to the Salicaceae family with intertropical distribution in America, Asia, and Oceania. Of the 100 accepted species, 22 are under some level of conservation risk. Around 13 species of the genus used as medicinal plants were found, mainly in Central and South America, with a variety of uses, among which antimicrobial is the most common.
  • 250
  • 18 May 2022
Topic Review
Xanthones
Xanthone is an aromatic oxygenated heterocyclic molecule, with a dibenzo-γ-pirone scaffold, known as 9H-xanthen-9-one, with the molecular formula of C13H8O2.
  • 659
  • 23 Feb 2021
Topic Review
Xanthone Glucosides
Xanthones are secondary metabolites found in plants, fungi, lichens, and bacteria froma variety of families and genera, with the majority found in the Gentianaceae, Polygalaceae, and Clusiaceae. They have a diverse range of bioactivities, including anti-oxidant, anti-bacterial, antimalarial, anti-tuberculosis, and cytotoxic properties. Xanthone glucosides are a significant branch of xanthones. After glycosylation, xanthones may have improved characteristics (such as solubility and pharmacological activity). Currently, no critical review of xanthone glucosides has been published.
  • 221
  • 25 Oct 2021
Topic Review
Voltage Gated Ion Channels
Safety Pharmacology is one of the most dynamically developing disciplines, whose objective is to assess the potential risks of improperly conducted pharmacotherapy. Evaluation of a potential risks in the use of a given substance is vital for placing a new medicine on the market. The Organisation for Economic Co-operation and Development (OECD) has issued a number of guidelines for drug safety testing [1, 2]. However, the continuous development of medicine demands the extension and refinement of the test panel that a new molecule must undergo before it can be released for use by patients. Toxic effects of compounds on the most important organs are among the most frequent reasons of elimination of substances from further tests. Additionally, safety tests are also performed for medicines already approved for use. Such trials are required, e.g., to register new indications for "old" drugs.  The above mentioned activities require a suitable identifications of the antitargets which are commonly defined as undesirable molecular targets that play an essential role in the proper functioning of cells. Down modulation of an antitarget results in clinically unacceptable side effects, initiation of disease, or deleterious alterations in disease progression. This results in shorter onset time of the disease, increased disease burden, poorer patient outcome, or decreased survival time.
  • 249
  • 27 Jan 2021
Topic Review
Volatilomics in Prostate Cancer
The lack of highly specific and sensitive biomarkers for the early detection of prostate cancer (PCa) is a major barrier to its management. Volatilomics emerged as a non-invasive, simple, inexpensive, and easy-to-use approach for cancer screening, characterization of disease progression, and follow-up of the treatment’s success.
  • 130
  • 24 Aug 2022
Topic Review
Various Uses of Lycopene
Lycopene is a carotenoid abundantly found in red vegetables. This natural pigment displays an important role in human biological systems due to its excellent antioxidant and health-supporting functions, which show a protective effect against cardiovascular diseases, hypertension, cancers, and diabetes.
  • 236
  • 28 Feb 2022
Topic Review
Vanadium and Melanoma
Melanoma is the most aggressive type of skin cancer, the incidence of which has been increasing annually worldwide.
  • 190
  • 08 Jun 2021
Topic Review
Use of Kojic Acid in Cosmetics
In 1907, Saito discovered Kojic Acid (KA), a natural product; it has since become one of the most investigated skin-lightening agents. KA inhibits tyrosinase and has been commonly researched in the cosmetic industry. It is incorporated in many kinds of cosmetic products.
  • 169
  • 23 Jun 2022
Topic Review
Ultra-High-Purity Aluminum
Properties of high-purity aluminum are the low magnetic permeability, the absence of low-temperature brittleness, as well as the increased strength and plasticity at low temperatures. These explain the classical application of high- to ultra-high-purity aluminum for the stabilization of superconductors running at cryogenic temperatures as low as −269 °C.
  • 310
  • 01 Nov 2021
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