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Topic Review
Non-Alkaloid Cholinesterase Inhibitory Compounds
The classes of cholinesterase inhibitors discussed here are mainly terpenoids, phenolic compounds, and coumarins, and some of these compounds have shown high potency. In order to consider which classes are most suitable, based on the benefits and drawbacks, certain structural features of each class will be of great importance. Using chalcones as an example, it is believed that besides economical and cost-effective production, small molecular size and flexibility for modifications to improve lipophilicity necessary for blood-brain barrier permeability are important to consider for a preferred potential therapeutic candidate for AD.
  • 518
  • 29 Sep 2021
Topic Review
Carbon Nano-Infused Cementitious Composites
A rising demand for efficient functional materials brings forth research challenges regarding improvements in existing materials. Carbon infused cementitious composites, regardless of being an important research topic worldwide, still present many questions concerning their functionality and properties.
  • 628
  • 29 Sep 2021
Topic Review
Applications of Functional Gold Nanoparticles
Gold nanoparticles were synthesized by Huang et al., Akiyama et al., and Mayya et al., obtaining an average diameter of the particles of about 10–50 nm. Ojea-Jiménez et al., investigating AuNP synthesis, demonstrated the influence of the sequence in the addition of the reagents. In the direct method, an aqueous solution of HAuCl4was heated up to 100 °C for 15 min and, finally, added with sodium citrate.
  • 601
  • 29 Sep 2021
Topic Review
Medicinal Potential of Isoflavonoids
In recent years, there is emerging evidence that isoflavonoids could play an important role in the management of type 2 diabetes mellitus (T2DM) due to their reported pronounced biological effects in relation to multiple metabolic factors associated with diabetes. Hence, in this regard, we have comprehensively reviewed the potential biological effects of isoflavonoids, particularly biochanin A, genistein, daidzein, glycitein, and formononetin on metabolic disorders and long-term complications induced by T2DM in order to understand whether they can be future candidates as a safe antidiabetic agent. Based on in-depth in vitro and in vivo studies evaluations, isoflavonoids have been found to activate gene expression through the stimulation of peroxisome proliferator-activated receptors (PPARs) (α, γ), modulate carbohydrate metabolism, regulate hyperglycemia, induce dyslipidemia, lessen insulin resistance, and modify adipocyte differentiation and tissue metabolism. Moreover, these natural compounds have also been found to attenuate oxidative stress through the oxidative signaling process and inflammatory mechanism. Hence, isoflavonoids have been envisioned to be able to prevent and slow down the progression of long-term diabetes complications including cardiovascular disease, nephropathy, neuropathy, and retinopathy. 
  • 559
  • 28 Sep 2021
Topic Review
Clinoptilolite Characterization and EDS Analysis
Zeolites are materials of biomedical interest, in particular owing to their ability to remove metabolic products such as uremic toxins (i.e., urea, uric acid, creatinine, p-cresol, and indoxul sulfate); they are used for the regeneration of dialysis solutions and as in vivo membranes for artificial kidney. Zeolites have further important applications in the biomedical field, in fact they are used as hemostats (due to their ability to absorb water), antiseptics (when modified with silver or zinc ions), carriers for drugs and genes (adjuvant in vaccines), glucose absorbers, etc. Here, EDS microanalysis in the study of a sample of natural clinoptilolite is reported. 
  • 1.7K
  • 28 Sep 2021
Topic Review
Carrageenan-Based Hard Capsules: Review
Carrageenan is used as a gelling agent in products, such as frozen foods, jellies and yogurt. Commercially, carrageenan has been produced in six different types based on their structures. Among the six polymers, κ-carrageenan is the most produced due to its high gelling ability caused by the C4 conformation on the 3,6-anhydro-D-galactopyranosyl that forms a helix-like structure. The formation of the helix structure is supported by the enormous number of –OH groups that form many hydrogen bonds.
  • 683
  • 28 Sep 2021
Topic Review
Bioadhesive Biomaterials for Medical Application
This entry deliberates about the importance of polymer based bioadhesive biomaterial’s medical application in healthcare and redefining healthcare management. Nowadays application of bioadhesion in health sector is one of the great interest for various researchers, due to its recent advances in their formulation development. Actually, this area of study is considered as an active multidisciplinary research approach, where engineers, scientists—including chemists, physicists, biologists, and medical experts—materials’ producers, and manufacturers combine their knowledge in order to provide a better healthcare. Moreover, while discussing about the implications of value-based healthcare, it is necessary to mention that health comprises three main domains namely: physical, mental, and social health that prioritized not only the quality healthcare, but it also enables to measure the outcomes of medical interventions. In addition, this conceptual article provides an understanding about the consequences of natural or synthetic polymer based bioadhesion of biomaterials and its significance for redefining healthcare management as a novel approach. Furthermore, research assumptions highlights that the quality healthcare concept has recently become a burning topic where, healthcare service providers, private research institutes, government authorities, public service boards, associations and academics took initiative to restructure the health care system to create value for patients and increase their satisfaction, and lead ultimately to a healthier society.
  • 1.5K
  • 28 Sep 2021
Topic Review
Potential of Carbon-Based Nanocomposites
While conventional dental implants focus on mechanical properties, recent advances in functional carbon nanomaterials (CNMs) accelerated the facilitation of functionalities including osteoinduction, osteoconduction, and osseointegration. The surface functionalization with CNMs in dental implants has emerged as a novel strategy for reinforcement and as a bioactive cue due to their potential for mechanical reinforcing, osseointegration, and antimicrobial properties. Numerous developments in the fabrication and biological studies of CNMs have provided various opportunities to expand their application to dental regeneration and restoration. In this review, we discuss the advances in novel dental implants with CNMs in terms of tissue engineering, including material combination, coating strategies, and biofunctionalities. We present a brief overview of recent findings and progression in the research to show the promising aspect of CNMs for dental implant application. In conclusion, it is shown that further development of surface functionalization with CNMs may provide innovative results with clinical potential for improved osseointegration after implantation. 
  • 619
  • 28 Sep 2021
Topic Review
Hydrogels and Dentin–Pulp Complex Regeneration
Abstract Dentin–pulp complex is a term which refers to the dental pulp (DP) surrounded by dentin along its peripheries. Dentin and dental pulp are highly specialized tissues, which can be affected by various insults, primarily by dental caries. Regeneration of the dentin–pulp complex is of paramount importance to regain tooth vitality. The regenerative endodontic procedure (REP) is a relatively current approach, which aims to regenerate the dentin–pulp complex through stimulating the differentiation of resident or transplanted stem/progenitor cells. Hydrogel-based scaffolds are a unique category of three dimensional polymeric networks with high water content. They are hydrophilic, biocompatible, with tunable degradation patterns and mechanical properties, in addition to the ability to be loaded with various bioactive molecules. Furthermore, hydrogels have a considerable degree of flexibility and elasticity, mimicking the cell extracellular matrix (ECM), particularly that of the DP. The current review presents how for dentin–pulp complex regeneration, the application of injectable hydrogels combined with stem/progenitor cells could represent a promising approach. According to the source of the polymeric chain forming the hydrogel, they can be classified into natural, synthetic or hybrid hydrogels, combining natural and synthetic ones. Natural polymers are bioactive, highly biocompatible, and biodegradable by naturally occurring enzymes or via hydrolysis. On the other hand, synthetic polymers offer tunable mechanical properties, thermostability and durability as compared to natural hydrogels. Hybrid hydrogels combine the benefits of synthetic and natural polymers. Hydrogels can be biofunctionalized with cell-binding sequences as arginine–glycine–aspartic acid (RGD), can be used for local delivery of bioactive molecules and cellularized with stem cells for dentin–pulp regeneration. Formulating a hydrogel scaffold material fulfilling the required criteria in regenerative endodontics is still an area of active research, which shows promising potential for replacing conventional endodontic treatments in the near future.
  • 997
  • 28 Sep 2021
Topic Review
Sustainable Machining of Steels
To improve occupational health and safety and the reduction of product costs, companies are moving towards sustainable manufacturing. Emphasizes the sustainable machining aspects of steel by employing techniques that require the minimal use of cutting oils, i.e., minimum quantity lubrication, and other efficient techniques like cryogenic cooling, dry cutting, solid lubricants, air/vapor/gas cooling, and cryogenic treatment. Cryogenic treatment on tools and the use of vegetable oils or biodegradable oils instead of mineral oils are used as primary techniques to enhance the overall part quality, which leads to longer tool life with no negative impacts on the environment. 
  • 780
  • 28 Sep 2021
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