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Topic Review
Applications of Ellagic Acid and Its Derivatives
Ellagitannins (ETs), characterized by their diversity and chemical complexity, belong to the class of hydrolysable tannins that, via hydrolysis under acidic or alkaline conditions, can yield ellagic acid (EA). They are mostly found as a part of extractives in angiosperms. As known antioxidants and chelators, EA and EA derivatives are drawing an increasing interest towards extensive technical and biomedical applications. 
  • 1.1K
  • 29 Mar 2022
Topic Review
Chinese Herb-Synthesized Silver Nanoparticles by Phytonanotechnology
Biologically synthesized silver nanoparticles (AgNPs) are potential antimicrobial agents commonly used in clinical treatment, such as wound dressing, topical ointments and anticancer agents. Recently, AgNPs with leaf and root extract ofPanax ginsenghave been successfully synthesized and showed potential antimicrobial activity. Different parts of Chinese herbs, including leaves, stenches, roots, and fruit extract, are widely applied for curing diseases.
  • 827
  • 29 Mar 2022
Topic Review
Cocona Fruits from the Peruvian Amazon
Cocona fruits are a popular food and medicinal fruit used mainly in the Amazon and several countries of South America for the preparation of several food products such as drinks, jams and milk shakes. In this study five ecotypes of cocona native to Peru have been studied regarding their nutritional and antioxidants values plus antihyperlipidemic activities.
  • 1.4K
  • 29 Mar 2022
Topic Review
Microneedles in Drug Delivery
In recent years, an innovative transdermal delivery technology has attracted great interest for its ability to distribute therapeutics and cosmeceuticals for several applications, including vaccines, drugs, and biomolecules for skin-related problems. The advantages of microneedle patch technology have been extensively evaluated in the latest literature; hence, the academic publications in this area are rising exponentially. 
  • 821
  • 29 Mar 2022
Topic Review
Recovery of Bioactive from Food Waste
Biowastes, especially food wastes, contain bioactive compounds that are suitable for producing functional foods, supplements, and nutricosmetics. Vegetables and fruits have primary metabolites (e.g., amino acids, lipids, dietary fibers, cellulose, hemicellulose, lignin, and fatty acids), and secondary metabolites (e.g., flavonoids, phenols, alkaloids, glucosinolates, carotenoids, and terpenes). The extraction of bioactive compounds from biowastes depends on the source, functionality, chemical properties, and end-use. Various temperatures, pH values, electromagnetic waves, and extraction techniques are used (e.g., supercritical fluid, subcritical water, ultrasonic wave, microwave, and pulsed electric field).
  • 735
  • 29 Mar 2022
Topic Review
PPARs in Treatment of Neuropsychiatric Disorders
Peroxisome proliferator-activated receptors (PPARs) are non-steroid nuclear receptors, which dimerize with the retinoid X receptor (RXR) and bind to PPAR-responsive regulatory elements (PPRE) in the promoter region of target genes. Recently, peroxisome proliferator-activated receptor (PPAR)-α and γ isoforms have been gaining consistent interest in neuropathology and treatment of neuropsychiatric disorders. 
  • 642
  • 29 Mar 2022
Topic Review
Medical Applications of Hybrid Hydrogels Containing Natural Polymers
Hybrid hydrogels definition is still debatable. They are defined either as a complex composed  chemically or physically cross-linking structures, or it refers to systems combining different polymers and/or with nanoparticles, such as plasmonic, magnetic, and carbonaceous nanoparticles, among others, or they are constituted by chemically, functionally, and morphologically distinct features from at least two different classes of molecules, which can include biologically active polymers as polysaccharides and/or proteins, peptides, or nano/microstructures, interconnected via physical or chemical means.
  • 1.7K
  • 29 Mar 2022
Topic Review
Complexes with Antibiofilm Activity
Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3d ions have shown promising potential for fighting biofilm-associated infections, due to their large spectrum antimicrobial and anti-biofilm activity. The literature usually reports species containing Mn(II), Ni(II), Co(II), Cu(II) or Zn(II) and a large variety of multidentate ligands with chelating properties such as antibiotics, Schiff bases, biguanides, N-based macrocyclic and fused rings derivatives. 
  • 512
  • 28 Mar 2022
Topic Review
Artificial Intelligence for COVID-19 De Novo Drug Design
Artificial intelligence (AI) refers to machines, mainly computers, working like humans. In AI, machines execute tasks such as speech recognition, solving problems, and learning. Machines can work and act like humans if they have enough instruction and knowledge. Drug development is a costly and time-consuming business, and only a minority of approved drugs generate returns exceeding the research and development costs. As a result, there is a huge drive to make drug discovery cheaper and faster. With modern algorithms and hardware, it is not too surprising that the new technologies of artificial intelligence and other computational simulation tools can help drug developers.
  • 654
  • 28 Mar 2022
Topic Review
GeSn Alloys for Photonic and Electronic Applications
GeSn materials have attracted considerable attention for their tunable band structures and high carrier mobilities, which serve well for future photonic and electronic applications.
  • 1.7K
  • 28 Mar 2022
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