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Topic Review
Inflammasome Regulation for IBD
Inflammasomes are multiprotein complexes formed to regulate the maturation of pro-inflammatory caspases, in response to intracellular or extracellular stimulants. Accumulating studies showed that the inflammasomes are implicated in the pathogenesis of inflammatory bowel disease (IBD), although their activation is not a decisive factor for the development of IBD. Inflammasomes and related cytokines play an important role in the maintenance of gut immune homeostasis, while its overactivation might induce excess immune responses and consequently cause tissue damage in the gut. Emerging studies provide evidence that some genetic abnormalities might induce enhanced NLRP3 inflammasome activation and cause colitis. In these cases, the colonic inflammation can be ameliorated by blocking NLRP3 activation or its downstream cytokine IL-1β. A number of natural products were shown to play a role in preventing colon inflammation in various experimental colitis models. On the other hand, lack of inflammasome function also causes intestinal abnormalities.
  • 652
  • 21 Apr 2021
Topic Review
Inelastic Neutron Scattering
Inelastic neutron scattering (INS) is a spectroscopy based on the energy analysis of neutrons after they have been scattered by a sample. A detected energy transfer can be related to a physical interaction of the corresponding atoms with their environment. An energy transfer of several meVs typically arises from vibrations of atoms. Thus, INS provides an amplitude-of-motion and neutron incoherent cross section weighted phonon density of states.  Given the much higher incoherent scattering cross section of hydrogen relative to that of all other elements, INS is particular sensitive to hydrogen based vibrations. The method is widely used in condensed matter physics and solid state chemistry, because the vibrational properties of matter define various physical properties such as the heat capacity. If used as a fingerprint method, INS can be used to characterize chemical bonds both in the bulk as well as on the surface.
  • 7.6K
  • 30 Oct 2020
Topic Review
Industrial Effluent and Sludge Toxicity
Industrial effluents and sludges are among the most critical sources of highly polluted and contaminated residues and can cause many environmental and ecological issues upon discharge to the environment. A comprehensive scientometric analysis has been carried out in this study to provide a clear understanding of the scientific efforts regarding the analysis of industrial effluents’ toxicity assessment. India and the USA accounted as the leading countries contributing the most in this regard by evaluating and analyzing the industrial effluent to avoid environmental contamination.
  • 1.0K
  • 06 Sep 2021
Topic Review
Industrial Applications of Microfluidic Systems
With the proliferation of microelectromechanical systems (MEMS) technology, the syntheses of microfluidic devices or microdroplets have become increasingly important as tools for chemical analysis and synthesis. Microfluidic devices (microreactors, microchemical chips, etc.) that integrate the functions of chemical synthesis, analysis equipment, and chemical plants in a compact form are being investigated.
  • 479
  • 26 Jan 2024
Topic Review
Indomethacin Increases HSA-Quercetin Binding
Human serum albumin (HSA) is the most abundant carrier protein in the human body. Competition for the same binding site between different ligands can lead to an increased active concentration or a faster elimination of one or both ligands. Indomethacin and quercetin both bind to the binding site located in the IIA subdomain. To determine the nature of the HSA-indomethacin-quercetin interactions, spectrofluorometric, docking, molecular dynamics studies, and quantum chemical calculations were performed. The results show that the indomethacin and quercetin binding sites do not overlap. Moreover, the presence of quercetin does not influence the binding constant and position of indomethacin in the pocket. However, binding of quercetin is much more favorable in the presence of indomethacin, with its position and interactions with HSA significantly changed. These results provide a new insight into drug-drug interactions, which can be important in situations when displacement from HSA or other proteins is undesirable or even desirable. This principle could also be used to deliberately prolong or shorten the xenobiotics' half-life in the body, depending on the desired outcomes.
  • 902
  • 06 Nov 2020
Topic Review
Indole-Based Macrocyclization by Metal-Catalyzed Approaches
Due to its immense importance, the progress of novel approaches for the synthesis of indole-based scaffolds has increased steadily. The majority of the macrocycles synthesis proceeds through the macrolactamization and macrolactonization, as well as the C–C bond macrocyclization process described by metal-catalyzed ring-closing metathesis (RCM) and coupling reactions.
  • 536
  • 21 Jul 2023
Topic Review
Indole Derivatives as Anti-Lung Cancer Agents
Indole scaffold is considered one of the most privileged scaffolds in heterocyclic chemistry. Indole may serve as an effective probe for the development of new drug candidates against challenging diseases, including lung cancer. 
  • 1.0K
  • 12 Nov 2021
Topic Review
Indium-Mediated Allylation
Indium-Mediated Allylations (IMAs) are important chemical reactions for the formation of carbon–carbon bonds. This reaction has two steps: first, indium inserts itself between the carbon–halogen bond of an allyl halide, becoming the organoindium intermediate; second, this allyl indide intermediate reacts with an electrophile to synthesize one of a wide range of compounds, such as carbohydrates and antihelminthic drugs. This reaction is depicted in the scheme below: Although this reaction occurs in two steps, it is commonly done as a Barbier reaction where the indium, allyl halide, and electrophile are all mixed together in a one-pot process. Indium reacts more readily than other metals, such as Mg, Pb, Bi, or Zn and does not require a promoter or flammable organic solvent to drive the reaction. IMAs have advantages over other carbon bond forming reactions because of their ability to be carried out in water, which is cheap and environmentally friendly. Therefore, these reactions represent Green chemistry, providing a safer alternative to the very common Grignard reaction, performed with Mg. Reactions yield high stereo- and regio-selectivity with few by-products making it easy to purify the desired product.
  • 868
  • 02 Dec 2022
Topic Review
Indirect Type Electrochemical Glycated Hemoglobin Sensors
Glycated hemoglobin (HbA1c) is the gold standard for measuring glucose levels in the diagnosis of diabetes due to the excellent stability and reliability of this biomarker. HbA1c is a stable glycated protein formed by the reaction of glucose with hemoglobin (Hb) in red blood cells, which reflects average glucose levels over a period of two to three months without suffering from the disturbance of the outside environment. A number of simple, high-efficiency, and sensitive electrochemical sensors have been developed for the detection of HbA1c. Indirect type electrochemical HbA1c sensors work based on the measurement of fructosyl valine/fructosyl valine histidine (FV or FVH), which is a form of enzymatic determination. According to the type of enzymes, indirect sensors are divided into fructosyl amino acid oxidase (FAO) type, fructosyl peptide oxidase (FPOX) type, and molecularly imprinted catalyst (MIC) type sensors. These enzymes usually need to be processed with nanotechnology or imprinting technology to immobilize them on the electrode surface. 
  • 578
  • 21 Apr 2022
Topic Review
Indigo for Non-Toxic and Ecological Gliding Surfaces
The biogenic substance E-indigo can form supramolecular, hydrophobic structures using self-organization. These structures show a low coefficient of friction as a gliding layer against polar surfaces. The formation of primary particles with platelet morphology based on hydrogen-bonded E-indigo molecules is ideal to produce the gliding layer. Structures with excellent gliding properties on ice, snow, and water can be achieved by means of directed friction and high pressure, as well as through tempering. The resulting hard, thin gliding layer of E-indigo does not easily absorb dirt and, thus, prevents a rapid increase in friction. Field tests on snow, with cross-country skis, have shown promising results in comparison to fluorinated and non-fluorinated waxes. Based on quantitative structure–activity relationship (QSAR) data for E-indigo, and its isomers and tautomers, it has been demonstrated that both the application and abrasion of the thin indigo layers are harmless to health, and are ecologically benign and, therefore, sustainable.
  • 806
  • 21 Feb 2022
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