Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Ligands for Alzheimer’s Disease therapy
Despite tremendous research efforts at every level, globally, there is still a lack of effectivedrugs for the treatment of Alzheimer's disease (AD). The biochemical mechanisms of this devastatingneurodegenerative disease are not yet clearly understood. This review analyses the relevance ofmultiple ligands in drug discovery for AD as a versatile toolbox for a polypharmacological approachto AD. Herein, we highlight major targets associated with AD, ranging from acetylcholine esterase(AChE), beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1), glycogen synthase kinase3 beta ( GSK-3β), N-methyl-D-aspartate (NMDA) receptor, monoamine oxidases (MAOs), metal ions inthe brain, 5-hydroxytryptamine (5-HT) receptors, the third subtype of histamine receptor (H3 receptor),to phosphodiesterases (PDEs), along with a summary of their respective relationship to the diseasenetwork. In addition, a multitarget strategy for AD is presented, based on reported milestones in thisarea and the recent progress that has been achieved with multitargeted-directed ligands (MTDLs).Finally, the latest publications referencing the enlarged panel of new biological targets for AD relatedto the microglia are highlighted. However, the question of how to find meaningful combinations oftargets for an MTDLs approach remains unanswered.
  • 1.0K
  • 04 Aug 2020
Topic Review
Life Cycle Assessment of Cellulose
The huge plastic production and plastic pollution are considered important global issues due to environmental aspects. One practical and efficient way to address them is to replace fossil-based plastics with natural-based materials, such as cellulose. The applications of different cellulose products have recently received increasing attention because of their desirable properties, such as biodegradability and sustainability.
  • 2.3K
  • 19 Feb 2021
Topic Review
Li7La3Zr2O12 (LLZO): An Overview
Li7La3Zr2O12 (LLZO) is an inorganic garnet type solid electrolyte which has proven to be one of the most promising electrolytes because of its high ionic conductivity at room temperature, low activation energy, good chemical and electrochemical stability, and wide potential window.
  • 2.5K
  • 03 Aug 2021
Topic Review
Li-ion Batteries
With the ever-growing energy storage notably due to the electric vehicle market expansion and stationary applications, one of the challenges of lithium batteries lies in the cost and environmental impacts of their manufacture. The main process employed is the solvent-casting method, based on a slurry casted onto a current collector. The disadvantages of this technique include the use of toxic and costly solvents as well as significant quantity of energy required for solvent evaporation and recycling. A solvent-free manufacturing method would represent significant progress in the development of cost-effective and environmentally friendly lithium-ion and lithium metal batteries.
  • 973
  • 11 Jan 2022
Topic Review
LGD Theory for Nanoscale Ferroelectrics
This is a entry of the Landau-Ginzburg-Devonshire (LGD) Theory applied for description of nanoscale ferroelectrics. The polarization switching kinetics of nanosized ferroelectric crystals and the transition between homogeneous and domain switching in the nanoscale ferroelectric films are considered. Homogeneous switching according to the Ginzburg-Landau-Devonshire (LGD) theory is possible only in two-dimensional (2D) ferroelectrics. The main condition for the applicability of the LGD theory in such systems is its homogeneity along the polarization switching direction. A review is given of the experimental results for two-dimensional (2D) films of a ferroelectric polymer, nanosized barium titanate nanofilms, and hafnium oxide-based films. For ultrathin 2D ferroelectric polymer films, the results are confirmed by first-principle calculations. Fitting of the transition region from homogeneous to domain switching by sigmoidal Boltzmann functions was carried out. Boltzmann function fitting data enabled us to estimate correctly the region sizes of the homogeneous switching in which the LGD theory is valid. These sizes contain several lattice constants or monolayers of a nanosized ferroelectrics.
  • 1.9K
  • 14 Jan 2021
Topic Review
Leaves of Diospyros kaki (Persimmon)
Diospyros kaki (persimmon) leaves have long been utilized as traditional medicine for the treatment of ischemic stroke, angina, and hypertension and as a healthy beverage and cosmetic for anti-aging. This study aimed to isolate as many compounds as possible from an ethanol extract of the persimmon leaves to identify the biologically active compounds. The antioxidative effect of the ethyl acetate layer from the ethanol extract of the persimmon leaves was demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and online high-performance liquid chromatography-2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (HPLC-ABTS) analysis. 
  • 773
  • 11 Nov 2021
Topic Review
Lead-Free Perovskite Solar Cells
Next-generation renewable energy sources and perovskite solar cells have revolutionised photovoltaics research and the photovoltaic industry. However, the presence of toxic lead in perovskite solar cells hampers their commercialisation. Lead-free tin-based perovskite solar cells are a potential alternative solution to this problem; however, numerous technological issues must be addressed before the efficiency and stability of tin-based perovskite solar cells can match those of lead-based perovskite solar cells.
  • 747
  • 18 Aug 2021
Topic Review
Lead-Free Perovskite Single Crystals
Lead-free perovskites have received remarkable attention because of their nontoxicity, low-cost fabrication, and spectacular properties including controlled bandgap, long diffusion length of charge carrier, large absorption coefficient, and high photoluminescence quantum yield. Compared with the widely investigated polycrystals, single crystals have advantages of lower trap densities, longer diffusion length of carrier, and extended absorption spectrum due to the lack of grain boundaries, which facilitates their potential in different fields including photodetectors, solar cells, X-ray detectors, light-emitting diodes, and so on. 
  • 728
  • 30 Nov 2021
Topic Review
Lead Halide Perovskites Opto-Electronic Devices
In Lead Halide Perovskites Opto-Electronic Devices, we will discuss the development in the LHP-based functional devices in recent years. After a brief presentation of the LHP's properties, we will focus on the functional devices including lasers, photodetectors, and modulators. Then the fabrication of the LHP-based devices will be presented, which is followed by the summary and outlook.
  • 648
  • 29 Apr 2021
Topic Review
Lead Azide at Microscale
Lead azide (LA) is a commonly used primary explosive, the detonation growth of which is difficult to study because it is so sensitive and usually has a small charge size in applications.
  • 684
  • 13 Apr 2022
  • Page
  • of
  • 467
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
ScholarVision Creations
Feedback