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Biography
Gottfried Heinisch
On 19 September 2019, the Pharmaceutical Science community in Austria lost a distinguished luminary, O. Univ.-Prof.i.R. Dr. Dr.h.c. Mag. pharm. Gottfried Heinisch, at the age of eighty after a long, severe illness. Born in 1938 to a Lower-Austrian Pharmacist’s family, Gottfried Heinisch studied pharmaceutical sciences at the University of Vienna, initially with the perspective of becoming a P
  • 408
  • 13 Sep 2022
Topic Review
Modification of Hyaluronic Acid to Improve Functionality
Native hyaluronic acid (HA) has found a broad range of applications in areas such as ophthalmology and cosmetics due to its unique physicochemical characteristics. However, this endogenous polymer is readily degraded in the body by the enzyme, hyaluronidase. The rate of degradation of native HA stifles its applicability to bioengineering applications or those which require a longer residence time in the body. To enable expansion of the applications of this polysaccharide, it can be modified to allow for cross-linking and engineering, to tailor the degradation profile in vivo, improve cell attachment, and enable conjugation. The relatively simple structure of HA allows for ease of modification of its two main functional groups- the hydroxyl and the carboxyl groups. Additionally, further synthetic modifications may be performed following the deacetylation of the acetamide group, which can allow for the recovery of amino functionalities. Regardless of the functional group to be modified, there are two options for modification; crosslinking or conjugation.
  • 1.2K
  • 13 Sep 2022
Topic Review
Catalysts for Synthesis of Ethylene-Propylene-Diene Rubbers
Ethylene-propylene-diene rubbers (EPDM) are one of the most important polyolefin materials widely commercialized and used in various industries in recent years. The production of EPDM is based solely on catalytic coordination polymerization processes. The development of new catalysts and processes for the synthesis of EPDM has expanded the range of products and their manufacturing in terms of energy efficiency, processability, and environmental safety.
  • 2.0K
  • 13 Sep 2022
Topic Review
Specific Bifunctionalization on the Phosphorus Dendrimers
Dendrimers are highly branched three-dimensional macromolecules, which properties are essentially dependent on the type of their terminal functions. Dendrimers are synthesized by iterative processes, which afford a new generation at the end of each sequence, characterized by a multiplication of the number of terminal functions. Such processes generate identical terminal functions on the surface of the dendrimers. However, it is sometimes desirable to have two types of surface functions in order to fulfil specific properties. Numerous properties have been explored already, most of them being related to catalysis, materials, or biology/nanomedicine. Strategies to get two types of terminal functions will be illustrated with polyphosphorhydrazone (PPH) dendrimers.
  • 675
  • 13 Sep 2022
Topic Review
Sumac as a Functional Food
Utilization of Rhus coriaria L. (sumac) is upgrading not only in their culinary use and human nutrition, but also in the pharmaceutical industry, food industry and veterinary practices. This is driven by accumulating evidence that support the ethnobotanical use of this plant; in particular, advanced knowledge of the content of nutritional, medicinal and techno-functional bioactive ingredients. Most of the antioxidant potential and therapeutic roles of sumac are increasingly attributed to its constituent tannins, flavonoids, and phenolic acids. Hydroxyphenyl pyranoanthocyanins and other anthocynins are responsible for the highly desired red pigments accounting for the strong pigmentation capacity and colorant ability of sumac. Certain polyphenols and the essential oil components are responsible for the peculiar flavor and antimicrobial activity of sumac. Tannin-rich sumac extracts and isolates are known to enhance the food quality and the oxidative stability of animal products such as meat and milk. In conclusion, polyphenol-rich sumac extracts and its bioactive ingredients could be exploited towards developing novel food products which do not only address the current consumers’ interests regarding organoleptic and nutritional value of food, but also meet the growing need for ‘clean label’ as well as value addition with respect to antioxidant capacity, disease prevention, and health promotion in humans.
  • 1.1K
  • 13 Sep 2022
Topic Review
3D-Printed Satellite Brackets
Brackets are the load-bearing components in a satellite. The current age of satellites comprises specific brackets that set out as a link between the bodies of the satellite, reflector parts, and feeder facilities mounted at its upper end. Brackets are used to carry loads of the satellite body frame, supporting elements, batteries, and electronic goods. Additive Manufacturing (AM) is a process in which a 3D solid object is built by adding the material layer-over-layer. The success of making the product using AM technology requires greater experience in Design for Additive Manufacturing (DFAM) which makes use of the design of freedom of AM. Owing to the various advantages of AM and DFAM, it is easy to create high strength-to-weight ratio products. This is an important contribution to aerospace industries in meeting the unabated demand for lightweight and strong structural applications.
  • 1.2K
  • 09 Sep 2022
Topic Review
Synthesis and Properties of Pyrazoles
Pyrazole derivatives are a special class of N-heterocyclic compounds (NHCps) bearing a heteroaromatic five-membered ring with two adjacent nitrogen atoms in the annular structure, one pyrrole-type (proton donor) and one pyridine-type (proton acceptor). Pyrazoles can act as weak bases or acids, with possible strength highly dependent on the nature of their substituent groups. The other three positions in the ring permit structural variants starting from the appropriate precursors or using post-functionalization reactions once the pyrazole ring is formed; these variations give the pyrazoles diverse and valuable synthetical, biological, and photophysical properties; indeed, more complex structures with various relevant examples can be formed from them.
  • 1.8K
  • 09 Sep 2022
Topic Review
Optimal Properties of the Scaffold
Osteoarthritis leads to the progressive decay of articular cartilage. Due to its intrinsic avascular character, cartilage shows an inadequate capacity for regeneration. Cartilage loss may result in chronic pain, movement disorder and morbidity, which lack effective treatments except for joint replacement for late-stage osteoarthritis. To overcome this challenge, tissue engineering has emerged as a promising method. Scaffolds provide mechanical and biochemical support to stem cells that undergo differentiation and secrete a cartilage-specific matrix, and this strategy has been proven to have positive results. The ideal 3D scaffolds need to have versatile properties to mediate cell–cell signalling and cell–matrix interactions for controlling the cellular behaviour of MSCs, specifically: (1) sufficient mechanical strength; (2) biocompatibility; (3) suitable surface morphology for cell attachment; (4) appropriate porosity and pore size to allow the cells to infiltrate as well as nutrients and waste to diffuse; (5) promoting cell proliferation, differentiation and maintenance of a chondrogenic phenotype of seeded cells; (6) capability of integrating with native tissues; and (7) controlled degradation without toxic byproducts.
  • 1.3K
  • 09 Sep 2022
Topic Review
New Liquid Chemical Hydrogen Storage Technology
The liquid chemical hydrogen storage technology has great potentials for high-density hydrogen storage and transportation at ambient temperature and pressure. However, its commercial applications highly rely on the high-performance heterogeneous dehydrogenation catalysts, owing to the dehydrogenation difficulty of chemical hydrogen storage materials. The chemists and materials scientists found that the supported metal nanoparticles (MNPs) can exhibit high catalytic activity, selectivity, and stability for the dehydrogenation of chemical hydrogen storage materials, which will clear the way for the commercial application of liquid chemical hydrogen storage technology. 
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  • 09 Sep 2022
Topic Review
Irradiation-Induced Amorphous-to-Crystalline Phase Transformations in Ceramic Materials
Ceramics are exposed to extreme irradiation environments in numerous applications, including nuclear fuels and claddings, immobilizing and storing nuclear waste, radiation shielding, space exploration and travel, and doping of semiconductors. In such environments, energetic particles impinging on crystalline ceramic materials lead to the creation of damage through various energy transfer mechanisms, culminating in changes to material microstructures, properties, and performance. Although crystalline ceramics have historically been used in practical irradiation-facing applications, amorphous ceramics have recently garnered interest for their unique properties and characteristics, including irradiation tolerance. Amorphous materials are purported to better resist irradiation than crystalline ceramics. The a-to-c transformations can be broadly categorized into three types: (1) athermal, resulting exclusively from either electron or ion irradiation of amorphous material, (2) resulting from the combined effects of heating and either ion or electron irradiation, or (3) epitaxial growth or recrystallization of an amorphous oxide due to ion or electron irradiation. 
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