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Topic Review
C-C and C-Heteroatom Bonds Construction
Acyl-containing organic compounds, including ketones, esters, amides, and so forth, are a huge library of widespread chemical feedstocks which play a vital role in countless fields such as pharmaceuticals, natural products, advanced materials, and fine chemicals.
  • 567
  • 28 Dec 2022
Topic Review
Additive Manufacturing of Intermetallic Alloys Based on Ti2AlNb
Titanium alloys based on orthorhombic titanium aluminide Ti2AlNb are promising refractory materials for aircraft engine parts in the operating temperature range from 600–700 °C. Parts made of Ti2AlNb-based alloys by traditional technologies, such as casting and metal forming, have not yet found wide application due to the sensitivity of processability and mechanical properties in chemical composition and microstructure compared with commercial solid-solution-based titanium alloys. Metal additive manufacturing (MAM) has attracted the attention of scientists and engineers for the production of intermetallic alloys based on Ti2AlNb. 
  • 567
  • 23 Feb 2023
Topic Review
Natural Silk and Silk Waste
Silk is one of the oldest and most useful animal fibres known to man. Silk thread is a product of the silk-producing glands of certain insects that create a net around themselves or form cocoons. The data obtained from previous studies show that the degree of silk waste practical use is still low, although silk is an expensive and highly valuable product. Furthermore, the use of natural resources to satisfy human needs also requires the extensive use of recyclable materials.
  • 567
  • 05 Jul 2023
Topic Review
Nanopore Technology in Gene Sequencing
Nanopore technology refers to nano-scale holes embedded in a thin membrane structure to detect the potential change when charged biological molecules smaller than nanopore pass through the hole. Therefore, nanopore technology has the potential to sense and analyze single-molecule amino acid, DNA, RNA, etc.. In this review, we will focus on the applications of nanopore technology in gene sequencing.
  • 566
  • 02 Aug 2021
Topic Review
Thymoquinone in Chemotherapy
Thymoquinone (2-Isopropl-5-methyl benzo-1,4-quinone) is an active component of the volatile oil of Nigella sativa (black seeds). Other than the Ranunculaceae family (N. sativa), this compound has been detected in other families such as Lamiaceae (Modernadidyma, M. menthifolia, etc.), Asteraceae (Eupatorium cannabinum), and Cupressaceae (Juniperus communis).
  • 566
  • 07 Jan 2022
Topic Review
Nanomedicine and Brain Tumors
A brain tumor, a tumor that develops within the skull, is an abnormal mass of tissue in which cells grow and multiply out of control. Although more than 150 types of brain tumors have been reported, they are macroscopically divided into primary and metastatic groups. Tumors that arise directly from the brain tissue or surrounding the brain are classified as primary brain tumors.
  • 566
  • 27 Jan 2022
Topic Review
DNA-Based Molecular Engineering of Cell Membrane
DNA, with intrinsic advantages of high versatility, programmability, and biocompatibility, has gained intense attention as a molecular tool for cell-surface engineering.
  • 566
  • 11 Feb 2022
Topic Review
Polyelectrolyte–Dye Interactions
Polyelectrolytes are polymers with repeating units of ionizable groups coupled with counterions. Recently, polyelectrolytes have drawn significant attention as highly promising macromolecular materials with potential for applications in almost every sector of our daily lives. Dyes are another class of chemical compounds that can interact with substrates and subsequently impart color through the selective absorption of electromagnetic radiation in the visible range.
  • 566
  • 07 Feb 2022
Topic Review
Hydrogen Storage Mechanism in Sodium-Based Graphene Nanoflakes
Carbon materials, such as graphene nanoflakes, carbon nanotubes, and fullerene, can be widely used to store hydrogen, and doping these materials with lithium (Li) generally increases their H2-storage densities. Unfortunately, Li is expensive; therefore, alternative metals are required to realize a hydrogen-based society. Sodium (Na) is an inexpensive element with chemical properties that are similar to those of lithium.
  • 566
  • 08 Feb 2022
Topic Review
Proteolysis-Targeting Chimeras
The ubiquitin–proteasome system (UPS) is an essential part of the cellular machinery responsible for maintaining intracellular protein homeostasis. A network of proteins that comprises the proteolytic system and chaperones calculates cellular protein homeostasis. Chaperones are in charge of correcting protein misfolding, but the proteolytic system, which converges on the 26S proteasome, is in charge of removing damaged or unfolded proteins to maintain a healthy environment inside the cell. Using proteolysis-targeting chimera (PROTAC) technology for targeted protein degradation, a novel technique of treatment is emerging that stems from an aberrant expression of a protein that causes disease. PROTAC molecules are tiny, bifunctional molecules that bind an E3-ubiquitin ligase and a target protein at the same time, causing ubiquitination and proteasome destruction of the target protein.
  • 566
  • 22 May 2023
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