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Topic Review
Cutaneous Flavonoid Delivery System
Flavonoids are one of the vital classes of natural polyphenolic compounds abundantly found in plants. Due to their wide range of therapeutic properties, which include antioxidant, anti-inflammatory, photoprotective, and depigmentation effects, flavonoids have been demonstrated to be promising agents in the treatment of several skin disorders. However, their lipophilic nature and poor water solubility invariably lead to limited oral bioavailability. In addition, they are rapidly degraded and metabolized in the human body, hindering their potential contribution to the prevention and treatment of many disorders. Thus, to overcome these challenges, several cutaneous delivery systems have been extensively studied. Topical drug delivery besides offering an alternative administration route also ensures a sustained release of the active compound at the desired site of action. Incorporation into lipid or polymer-based nanoparticles appears to be a highly effective approach for cutaneous delivery of flavonoids with good encapsulation potential and reduced toxicity.
  • 730
  • 22 Apr 2022
Topic Review
Plasma Electrolytic Oxidation Coating
Plasma electrolytic oxidation (PEO) is an effective surface modification method for producing ceramic oxide layers on metals and their alloys. Although inorganic electrolytes are widely used in PEO, the organic additives have received considerable interest in the last decade due to their roles in improving the final voltage and controlling spark discharging, which lead to significant improvements in the performance of the obtained coatings. 
  • 730
  • 30 Mar 2021
Topic Review
The Assembly of PPTA Nanofibers and the Applications
Poly (p-phenylene terephthalamide) (PPTA) is one kind of lyotropic liquid crystal polymer. Kevlar fibers made from PPTA is widely used in many fields due to the superior mechanical properties resulted from highly oriented macromolecular structure. However, the “infusible and insoluble” characteristic of PPTA gives rise to its poor processability, which limits its scope of application. The strong interactions and orientation characteristic of aromatic amide segments make PPTA attractive in the field of self-assembly. The chemical derivations have proved an effective way to modify the molecular structure of PPTA to improve its solubility and amphiphilicity, which resulted in different liquid crystal behaviors or supramolecular aggregates, but the modification of PPTA is usually complex and difficult. Alternatively, higher order all-PPTA structures have also been realized through the controllable hierarchical self-assembly of PPTA from the polymerization process to the formation of macroscopic products. It briefly introduces the self-assembly methods of PPTA based materials in recent years, and focuses on the polymerization-induced PPTA nanofibers which can be further fabricated into different macroscopic architectures when other self-assembly methods are combined. This monomer-started hierarchical self-assembly strategy evokes the feasible processing of PPTA, and enriches the diversity of product, which is expected to be expanded to other liquid crystal polymers.
  • 730
  • 20 Jul 2022
Topic Review Peer Reviewed
Solid Lipid Nanoparticles
Solid lipid nanoparticles (SLNs) are produced from physiologically biocompatible lipids. They have been proven to improve solubility, cellular uptake, and stability, reduce enzyme degradation, and prolong the circulation time of various drugs. SLNs have been applied in the oral, parenteral, transdermal, intranasal, ocular, and pulmonary drug delivery of different drugs, with enhanced safety, bioavailability, and overall therapeutic effects. In this entry, the authors summarize the primary features of SLNs, methods to prepare SLNs, and recent applications of SLNs in drug delivery. Owing to their advantages, SLNs are potential drug delivery systems to improve the management of various diseases and will, soon, be available for clinical use. 
  • 730
  • 24 May 2022
Topic Review
Imogolite Nanotubes
Imogolite nanotubes (INTs) represent a model of nanoplatforms with an untapped potential for advanced technological applications. Easily synthesized by sol-gel methods, these nanotubes are directly obtained with a monodisperse pore size. Coupled with the possibility to adjust their surface properties by using straightforward functionalization processes, INTs form a unique class of diameter-controlled nanotubes with functional interfaces. 
  • 729
  • 22 Jun 2021
Topic Review
Principles of Prototropic Equilibria
Prototropic tautomers always differ by the positions of labile proton(s) and π-electrons. The number of possible tautomeric forms is an internal property of the tautomeric molecule. It is a consequence of the number of labile protons and the number of conjugated tautomeric sites.
  • 729
  • 01 Nov 2023
Topic Review
Strategies for the Preparation of Phosphorus Janus Dendrimers
Dendrimers, being highly branched monodispersed macromolecules, predominantly exhibit identical terminal functionalities within their structural framework. Nonetheless, there are instances where the presence of two distinct surface functionalities becomes advantageous for the fulfilment of specific properties. To achieve this objective, one approach involves implementing Janus dendrimers, consisting of two dendrimeric wedges terminated by dissimilar functionalities.
  • 728
  • 21 Aug 2023
Topic Review
Surface Activation of Polytetrafluoroethylene
Fluorinated polymers are renowned for their chemical inertness and thus poor wettability and adhesion of various coatings. Apart from chemical methods employing somewhat toxic primers, gaseous plasma treatment is a popular method for the modification of surface properties. Different authors have used different plasmas, and the resultant surface finish spans between super-hydrophobic and super-hydrophilic character.
  • 728
  • 19 Oct 2020
Topic Review
Gelatin-Based Hybrid Scaffolds
Gelatin is a biopolymer with interesting properties that have greatly attracted the attention of many biomedical researchers, such as low antigenicity, good biodegradability, and biocompatibility in the physiological environment. The gelatin-based materials offer excellent characteristics of wound dressings. The fast degradation time and highly hydrophilic surface make gelatin inappropriate as a base material for the development of wound dressings.
  • 727
  • 08 Sep 2021
Topic Review
Betulin
Betulin is an important triterpenoid substance isolated from birch bark, which, together with its sulfates, exhibits important bioactive properties. Using the potentiometric titration method, the product of acidity constants K1 and K2 of a solution of the betulin disulfate H+ form has been found to be 3.86 × 10–6 ± 0.004. It has been demonstrated by the thermal analysis that betulin and the betulin disulfate sodium salt are stable at temperatures of up to 240 and 220 °C, respectively. 
  • 725
  • 28 Feb 2022
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