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Topic Review
Calcium Phosphate Cements as Carriers of Functional Substances
Interest in calcium phosphate cements as materials for the restoration and treatment of bone tissue defects is still high. Despite commercialization and use in the clinic, the calcium phosphate cements have great potential for development. Existing approaches to the production of calcium phosphate cements as drugs are analyzed. 
  • 359
  • 12 Jun 2023
Topic Review
Calcium Phosphate Nanocluster Complexes
Calcium phosphate nanocluster complexes comprise a core of amorphous calcium phosphate and a sequestering shell of intrinsically disordered phosphopeptides or phosphoproteins. Solutions containing the nanocluster complexes can be thermodynamically stable or metastable due to a tendency to form a precipitate enriched in calcium phosphate. Theoretical and biophysical studies with native and recombinant phosphopeptides have shown how the radius of the core and the stability of the solution depend on the concentration of the sequestering peptide, its affinity for the calcium phosphate and its concentration in relation to the concentration of the calcium phosphate. The thickness of the sequestering shell depends on the conformation of the peptide on the core surface. A sequestering peptide is a flexible sequence including one or more short linear motifs, each of which usually contains several phosphorylated and other acidic residues.  These are the main binding sites to the core so that a peptide with several binding motifs can forms loops and trains on the core surface. Calcium phosphate nanocluster complexes were first identified as substructures of casein micelles in milk and have been prepared as individual particles from peptides derived from caseins and osteopontin. Stable biofluids containing nanocluster complexes cannot cause soft tissues to become mineralized whereas stable or metastable biofluids containing nanocluster complexes can help to mineralize hard tissues.
  • 1.5K
  • 09 Nov 2020
Topic Review
Calcium Phosphate Nanoparticles in Bone
Bone injuries and diseases constitute a burden both socially and economically, as the consequences of a lack of effective treatments affect both the patients’ quality of life and the costs on the health systems. This impended need has led to a recent focus on the development of efficacious bone tissue engineering solutions. Here, the use of biomaterial-based nanoparticles for the delivery of therapeutic factors is summrised. Among the biomaterials being considered to date, calcium phosphates have emerged as one of the most promising materials for bone repair applications due to their osteoconductivity, osteoinductivity and their ability to be resorbed in the body. Calcium phosphate nanoparticles have received particular attention as non-viral vectors for gene therapy, as factors such as plasmid DNAs, microRNAs (miRNA) and silencing RNA (siRNAs) can be easily incorporated on their surface. Calcium phosphate nanoparticles loaded with therapeutic factors have also been delivered to the site of bone injury using scaffolds and hydrogels. Here an overview of the use of calcium phosphate nanoparticles as carriers for therapeutic factors for application in bone tissue engineering is provided.
  • 1.7K
  • 30 Oct 2020
Topic Review
Calcium Phosphate Scaffolds
Bone is a complex biologic tissue, which is extremely relevant for various physiological functions, in addition to movement, organ protection, and weight bearing. The repair of critical size bone defects is a still unmet clinical need, and over the past, material scientists have been expending efforts to find effective technological solutions, based on the use of scaffolds. In this context, biomimetics which is intended as the ability of a scaffold to reproduce compositional and structural features of the host tissues, is increasingly considered as a guide for this purpose. However, the achievement of implants that mimic the very complex bone composition, multi-scale structure, and mechanics is still an open challenge. Indeed, despite the fact that calcium phosphates are widely recognized as elective biomaterials to fabricate regenerative bone scaffolds, their processing into 3D devices with suitable cell-instructing features is still prevented by insurmountable drawbacks. With respect to biomaterials science, new approaches maybe conceived to gain ground and promise for a substantial leap forward in this field. 
  • 310
  • 01 Sep 2022
Topic Review
Calcium Phosphate-Based Nanomaterials in Bone Tissue Engineering
Calcium phosphate is the main inorganic component of bone. Calcium phosphate-based biomaterials have demonstrated great potential in bone tissue engineering due to their superior biocompatibility, pH-responsive degradability, excellent osteoinductivity, and similar components to bone. Calcium phosphate nanomaterials have gained more and more attention for their enhanced bioactivity and better integration with host tissues. Additionally, they can also be easily functionalized with metal ions, bioactive molecules/proteins, as well as therapeutic drugs; thus, calcium phosphate-based biomaterials have been widely used in many other fields, such as drug delivery, cancer therapy, and as nanoprobes in bioimaging.
  • 260
  • 29 Jun 2023
Topic Review
Calcium Silicate-Based Materials - Antimicrobial
Endodontic materials have significantly improved dental treatment techniques in several aspects as they can be used for vital pulp treatments, as temporary root canal medication, in definitive fillings, in apical surgeries, and for regenerative procedures. Calcium silicate-based cement is a class of dental material that is used in Endodontics in direct contact with the dental structures, connective tissue, and bone. Because the material interacts with biological tissues and stimulates biomineralization processes, its properties are of major importance. The main challenge in endodontic treatments is the elimination of biofilms that are present in the root canal system anatomical complexities, as it remains even after chemical-mechanical preparation and disinfection procedures. Thus, an additional challenge for these biomaterials is to exert antimicrobial activity while maintaining their biological properties in parallel.
  • 730
  • 29 Jul 2021
Topic Review
Calcium-Dependent Protein Kinases
Calcium-dependent protein kinases (CDPKs) comprise a unique family of serine/threonine kinases only found in plants, protozoans (including apicomplexan parasites) and some algae. As these enzymes play an important role in calcium signalling during the various life stages of the Plasmodium parasite, CDPKs have been identified as potential targets for next-generation antimalarial drug development.  This entry focusses on the different CDPKs identified for Plasmodium falciparum, their possible functions, and the small-molecule inhibitors developed thus far for this group of kinases.
  • 527
  • 27 Dec 2020
Topic Review
Calculations on Ion Channels
Ion channels are proteins that allow the passage of ions across biological membranes; particularly important cations include Na+, K+, and Ca++. Nerve impulse transmission involves Na+ and K+ channels; the advantages of quantum calculations are discussed.
  • 616
  • 14 May 2021
Topic Review
Camelids' Milk
Camel milk has always represented an important food for nomadic people in the arid parts of the world; recently, camel milk attracted great attention as a possible replacer to dairy cow’s milk because of its therapeutic effects. The use of alternative milk for feeding children can be effective in reducing the development of gastrointestinal disorders.
  • 739
  • 19 Apr 2022
Topic Review
CAMPUS (Database)
CAMPUS (acronym for Computer Aided Material Preselection by Uniform Standards) is a multilingual database for the properties of plastics. It is considered worldwide as a leader in regard to the level of standardization and therefore, ease of comparison, of plastics properties. It also supports diagrams to a large extent. CAMPUS is based on ISO standards 10350, for single-point value e.g. the density, and 11403, for diagrams, e.g. the Stress–strain curve.
  • 343
  • 31 Oct 2022
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