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Chen, X.; Li, H.; Ma, Y.; Jiang, Y. Calcium Phosphate-Based Nanomaterials in Bone Tissue Engineering. Encyclopedia. Available online: https://encyclopedia.pub/entry/46200 (accessed on 07 July 2024).
Chen X, Li H, Ma Y, Jiang Y. Calcium Phosphate-Based Nanomaterials in Bone Tissue Engineering. Encyclopedia. Available at: https://encyclopedia.pub/entry/46200. Accessed July 07, 2024.
Chen, Xin, Huizhang Li, Yinhua Ma, Yingying Jiang. "Calcium Phosphate-Based Nanomaterials in Bone Tissue Engineering" Encyclopedia, https://encyclopedia.pub/entry/46200 (accessed July 07, 2024).
Chen, X., Li, H., Ma, Y., & Jiang, Y. (2023, June 29). Calcium Phosphate-Based Nanomaterials in Bone Tissue Engineering. In Encyclopedia. https://encyclopedia.pub/entry/46200
Chen, Xin, et al. "Calcium Phosphate-Based Nanomaterials in Bone Tissue Engineering." Encyclopedia. Web. 29 June, 2023.
Calcium Phosphate-Based Nanomaterials in Bone Tissue Engineering
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This entry is adapted from the peer-reviewed paper 10.3390/molecules28124790

Calcium phosphate is the main inorganic component of bone. Calcium phosphate-based biomaterials have demonstrated great potential in bone tissue engineering due to their superior biocompatibility, pH-responsive degradability, excellent osteoinductivity, and similar components to bone. Calcium phosphate nanomaterials have gained more and more attention for their enhanced bioactivity and better integration with host tissues. Additionally, they can also be easily functionalized with metal ions, bioactive molecules/proteins, as well as therapeutic drugs; thus, calcium phosphate-based biomaterials have been widely used in many other fields, such as drug delivery, cancer therapy, and as nanoprobes in bioimaging.

calcium phosphate nanomaterials bone tissue engineering multifunction drug delivery bioimaging

1. Introduction

Nowadays, over two million bone grafts are needed for bone defects [1][2], which are caused by trauma, infection, and tumors, since the size of the defect is far larger than the self-healing capability of bone tissue. Autologous bone grafts are still considered the gold standard to achieve bone defect repair [3][4]. Allografts also show excellent bioactivity, but the drawbacks are still obvious, including possible disease transmission, immune rejection, second injury, and donor site morbidity [5]. Thus, various bone substitutes have been made to solve the limitation of bone repair caused by the autologous bone, such as inorganic implants or organic implants. Usually, inorganic implants used for bone defects tend to be peri-implantitis [6], be non-degradable [7], and lack osteoinductivity [8], which bring about the continuous inhibition of bone regeneration and cause the absence of strong and effective mechanical support from newborn bone. Thus, patients may suffer a lot from default treatment.
Bone tissue engineering is a promising approach for the regeneration and repair of damaged bone tissues. Biomaterial-based approaches have emerged as an alternative to these traditional methods. Biomaterials can provide a scaffold for cell adhesion, proliferation, and differentiation, and they can also release growth factors and other bioactive molecules to promote bone regeneration. Biomaterials used for bone tissue engineering should have properties such as biocompatibility, biodegradability, osteoconductivity, and osteoinductivity. Biomaterials can be classified into the following four categories based on their composition: calcium phosphate-based biomaterials, metallic biomaterials, polymeric biomaterials, and composite biomaterials. Among these, calcium phosphate-based biomaterials have received the most attention due to their excellent biocompatibility, bioactivity, and similarity to the mineral component of bone [9][10].
Compared to conventional calcium phosphate-based graft materials, calcium phosphate nanomaterials offer several distinct advantages and show unique properties for bone tissue engineering, including enhanced bioactivity, tailored physical and chemical properties, controlled drug delivery, better integration with host tissue, and ease of fabrication and scalability. Specifically, these biomaterials have a high surface area to volume ratio, which provides more space for cell adhesion and proliferation and also promotes cell differentiation [11][12], as well as loading more therapeutic ingredients [13][14]. Additionally, the nano-sized particles can enhance the mechanical properties and show a profile of controlled drug release.
Thus, calcium phosphate nanomaterials have attracted more and more attention, and various preparation strategies have been developed to satisfy clinical requirements. The preparation methods include wet chemical precipitation, solvothermal synthesis, the sol-gel method, microwave-assisted method, sonochemical synthesis, the enzyme-assisted method, as well as spray drying and electrospinning. Among these, the precipitation method is the most commonly used method for the preparation of nano-calcium phosphate-based biomaterials, while the other methods also have their advantages, which are further discussed in the following section.
Furthermore, calcium phosphate-based nanomaterials can be tailored by adjusting their size, shape, and surface chemistry. Functionalized calcium phosphates are endowed with osteogenic properties, angiogenic properties, antimicrobial properties, bioimaging capabilities, and so on. Herein, calcium phosphate-based nanomaterials showed great potential in bone regeneration, antitumor therapy, and drug delivery. Thus, the research is intended to give a comprehensive summary of the preparation, multifunctionality, and application of nano calcium phosphate-based biomaterials for bone tissue engineering, and it also addresses the attention of readers and provides inspiration for the design of bioactive materials for bone tissue engineering.

2. Applications of Calcium Phosphate-Based Nanomaterials in Bone Tissue Engineering

Calcium phosphate-based nanomaterials show superior biocompatibility, show osteoinductivity, and have high surface area and porosity. Thus, they have been widely used for bone regeneration [15]. Additionally, calcium phosphate-based nanomaterials can be doped with special compounds to promote bone repair directly. Susmita et al. designed 3D calcium phosphate scaffolds, resembling the structure of cortical and cancellous bones, to provide a stronger, denser structure to develop compressive strengths of the scaffold and maintain the central interconnected porosity for cell proliferation and vascularization. The scaffold was incorporated with natural compounds from ginger root and garlic powder, which can enhance bone healing when used in vivo, and improved the bioavailability of these medicinal compounds [16]. Furthermore, many metal elements also have various influences on the process of bone regeneration, such as silicon, magnesium, cerium, and so on. Based on this theory, Fe and Zn were combined with tricalcium phosphate (TCP) via co-deposition because these two elements can improve new blood vessel formation, which can significantly promote bone regeneration; then, the Fe/Zn-modified TCP powders were turned into a solid, and micropores were formed inside at room temperature. The composites achieved the sustained release of metal (Ca2+, Zn2+ and Fe3+) ions, which can promote the process of bone repair [17]. Additionally, because of the low mechanical strength, brittleness, and quick resorption rate, CaP-based scaffolds need to be reinforced with mechanical strength and be improved regarding bioactivity. It is reported that bioceramic powders (hydroxyapatite and β-tricalcium phosphate) have been embedded in mixed solutions of chitosan and silk fibroin to improve both the mechanical properties and the differentiation of mesenchymal stem cells since chitosan and silk fibroin have shown better bioactivity in supporting the growth and differentiation of BMSCs. Additionally, the polymer solution can be used as the bioink of robocasting equipment to print 3D scaffolds with fixed system parameters at room temperature, and this scaffold achieved great performance regarding mechanical properties and biocompatibility [18]. Calcium phosphate-based materials can also be used as carriers to load cells or growth factors, which can improve effective therapeutic ingredients in bone defect areas, can keep the sustained release of these factors, and can provide enough room for osteoblasts and new blood vessels [19]. Li et al. reported that bone marrow mesenchymal stem cells and platelet-rich plasma combined with a calcium phosphate cement scaffold achieved more newly formed bone areas than normal calcium phosphate cement scaffolds in an in vivo experiment [20].
Recently, near-infrared-emitting persistent luminescence nanoparticles have been used as an optical probe for bioimaging and biosensing [21][22]. Though they show low absorptivity in deep-tissue imaging, achieving stable in vivo luminescence is still a great challenge [23]. Chen et al. developed Eu3+/Gd3+ ion-dual-doped CaP nanoparticles via co-precipitation using block copolymer polylactide-block-monomethoxy as a template. The nanoparticles showed prolonged stability (more than 80 days), improved the T1-weighted MRI signal intensity, and decreased T2-weighted MRI signal intensity, which resulted in darker images for the better observation of changes in local areas in vivo [24]. Additionally, to monitor the in vivo performance of calcium phosphate cements, which show a high structural similarity to bone [25], calcium phosphate cements linked with gadolinium (III) by bisphosphonates were developed, and they showed shortened T1 relaxation times of the water in tissues and achieved signal enhancement in a T1-weighted MRI. In this way, the highly accurate evaluation of the implant shape both in MRI and CT for a prolonged time period (about 8 weeks) was achieved [26].
Calcium phosphate-based nanoparticles are also desirable materials for drug delivery [27]. Doxorubicin could activate the immunogenic cell death of tumor cells through an apoptosis pathway, including reactive oxygen species, which could lead to DNA cleavage and mitochondrial dysfunction [28], while the multidrug resistance of cancers may result in poor prognosis [29]. To address this issue, a selenium-doped CaP, serving as the doxorubicin carrier, was designed for reversing the multidrug resistance of tumors. Se-doped CaP is pH-sensitive and dox can be released specifically in the tumor sites due to the acid microenvironment. Thus, the uptake of anticancer drugs of tumor cells was raised, and Se ions released could decrease reactive oxygen species of tumor cells and the expression of ATP-binding cassette transporters, which reverse multidrug resistance [30]. The surgery of bone tumors causes large bone defects, and calcium phosphate bone pastes have been widely used as bone substitutes in clinics to replace allogenous bone, providing strong and stable support for the defect sites without internal fixation [31][32], for many years, and the result of anticancer is also well described in the long run [33][34]. Furthermore, there is the theory that calcium ions play a vital role in tumor necrosis by regulating the stability of the intracellular concentration of calcium ions [35][36][37], and a high concentration of calcium in the microenvironment of the tumor can encourage tumor calcification [38][39]. Based on this phenomenon, calcium phosphate can combine with some special materials, such as ferritin, which is a promising load for targeted delivery, to protect ferritin from interception to achieve the function of targeted delivery to the tumor effectively, and the shell of calcium phosphate not only counterbalances the acidic microenvironment around tumors but also accelerates the immunomodulation and calcification of cancers [40][41]. CaP nanoparticles can also be coated to camouflage, which may result in intracellular calcium overload and induce apoptosis. For example, TiO2-coated CaP can elevate the generation of reactive oxygen species, due to the demonstrative property of inorganic sonosensitizers, and can provide calcium ions due to the acidic microenvironment of the tumor [42][43][44].

References

  1. Kahar, N.N.F.; Ahmad, N.; Jaafar, M.; Yahaya, B.H.; Sulaiman, A.R.; Hamid, Z.A.A. A review of bioceramics scaffolds for bone defects in different types of animal models: HA andbeta-TCP. Biomed. Phys. Eng. Express 2022, 8, 21.
  2. Greenwald, A.S.; Boden, S.D.; Goldberg, V.M.; Khan, Y.; Laurencin, C.T.; Rosier, R.N. Bone-graft substitutes: Facts, fictions, and applications. J. Bone Joint Surg. Am. 2001, 83 (Suppl. 2), S98–S103.
  3. Wang, J.; Li, W.; He, X.; Li, S.; Pan, H.; Yin, L. Injectable platelet-rich fibrin positively regulates osteogenic differentiation of stem cells from implant hole via the ERK1/2 pathway. Platelets 2023, 34, 2159020.
  4. Ng, J.; Spiller, K.; Bernhard, J.; Vunjak-Novakovic, G. Biomimetic Approaches for Bone Tissue Engineering. Tissue Eng. Part B Rev. 2017, 23, 480–493.
  5. Fu, Q.; Saiz, E.; Rahaman, M.N.; Tomsia, A.P. Toward Strong and Tough Glass and Ceramic Scaffolds for Bone Repair. Adv. Funct. Mater. 2013, 23, 5461–5476.
  6. Tomasi, C.; Regidor, E.; Ortiz-Vigón, A.; Derks, J. Efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects. A systematic review and meta-analysis. J. Clin. Periodontol. 2019, 46 (Suppl. 21), 340–356.
  7. Amini, Z.; Lari, R. A systematic review of decellularized allograft and xenograft-derived scaffolds in bone tissue regeneration. Tissue Cell 2021, 69, 101494.
  8. Fillingham, Y.; Jacobs, J. Bone grafts and their substitutes. Bone Joint J. 2016, 98-B, 6–9.
  9. Zhao, R.; Yang, R.; Cooper, P.R.; Khurshid, Z.; Shavandi, A.; Ratnayake, J. Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments. Molecules 2021, 26, 3007.
  10. Xu, H.H.; Wang, P.; Wang, L.; Bao, C.; Chen, Q.; Weir, M.D.; Chow, L.C.; Zhao, L.; Zhou, X.; Reynolds, M.A. Calcium phosphate cements for bone engineering and their biological properties. Bone Res. 2017, 5, 17056.
  11. Yang, Y.; Su, S.; Liu, S.; Liu, W.; Yang, Q.; Tian, L.; Tan, Z.; Fan, L.; Yu, B.; Wang, J.; et al. Triple-functional bone adhesive with enhanced internal fixation, bacteriostasis and osteoinductive properties for open fracture repair. Bioact. Mater. 2023, 25, 273–290.
  12. Idaszek, J.; Jaroszewicz, J.; Choinska, E.; Gorecka, Z.; Hyc, A.; Osiecka-Iwan, A.; Wielunska-Kus, B.; Swieszkowski, W.; Moskalewski, S. Toward osteomimetic formation of calcium phosphate coatings with carbonated hydroxyapatite. Biomater. Adv. 2023, 149, 213403.
  13. Tabaković, A.; Kester, M.; Adair, J.H. Calcium phosphate-based composite nanoparticles in bioimaging and therapeutic delivery applications. Wiley Interdiscip. Rev.—Nanomed. Nanobiotechnol. 2012, 4, 96–112.
  14. Zhu, Q.; Chen, Z.; Paul, P.K.; Lu, Y.; Wu, W.; Qi, J. Oral delivery of proteins and peptides: Challenges, status quo and future perspectives. Acta Pharm. Sin. B 2021, 11, 2416–2448.
  15. Duraisamy, K.; Gangadharan, A.; Martirosyan, K.S.; Sahu, N.K.; Manogaran, P.; Easwaradas Kreedapathy, G. Fabrication of Multifunctional Drug Loaded Magnetic Phase Supported Calcium Phosphate Nanoparticle for Local Hyperthermia Combined Drug Delivery and Antibacterial Activity. ACS Appl. Bio Mater. 2023, 6, 104–116.
  16. Bose, S.; Banerjee, D.; Vu, A.A. Ginger and Garlic Extracts Enhance Osteogenesis in 3D Printed Calcium Phosphate Bone Scaffolds with Bimodal Pore Distribution. ACS Appl. Mater. Interfaces 2022, 14, 12964–12975.
  17. Xie, L.; Yang, Y.; Fu, Z.; Li, Y.; Shi, J.; Ma, D.; Liu, S.; Luo, D. Fe/Zn-modified tricalcium phosphate (TCP) biomaterials: Preparation and biological properties. RSC Adv. 2019, 9, 781–789.
  18. Torres, P.M.C.; Ribeiro, N.; Nunes, C.M.M.; Rodrigues, A.F.M.; Sousa, A.; Olhero, S.M. Toughening robocast chitosan/biphasic calcium phosphate composite scaffolds with silk fibroin: Tuning printable inks and scaffold structure for bone regeneration. Biomater. Adv. 2022, 134, 112690.
  19. Shakoor, S.; Kibble, E.; El-Jawhari, J.J. Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration. Bioengineering 2022, 9, 15.
  20. Li, G.; Shen, W.; Tang, X.; Mo, G.; Yao, L.; Wang, J. Combined use of calcium phosphate cement, mesenchymal stem cells and platelet-rich plasma for bone regeneration in critical-size defect of the femoral condyle in mini-pigs. Regen. Med. 2021, 16, 451–464.
  21. Xie, W.; Jiang, W.; Zhou, R.; Li, J.; Ding, J.; Ni, H.; Zhang, Q.; Tang, Q.; Meng, J.-X.; Lin, L. Disorder-Induced Broadband Near-Infrared Persistent and Photostimulated Luminescence in Mg2SnO4:Cr3. Inorg. Chem. 2021, 60, 2219–2227.
  22. Xue, Z.; Li, X.; Li, Y.; Jiang, M.; Liu, H.; Zeng, S.; Hao, J. X-ray-Activated Near-Infrared Persistent Luminescent Probe for Deep-Tissue and Renewable In Vivo Bioimaging. ACS Appl. Mater. Interfaces 2017, 9, 22132–22142.
  23. Shiu, W.-T.; Chang, L.-Y.; Jiang, Y.; Shakouri, M.; Wu, Y.-H.; Lin, B.-H.; Liu, L. Synthesis and characterization of a near-infrared persistent luminescent Cr-doped zinc gallate-calcium phosphate composite. Phys. Chem. Chem. Phys. 2022, 24, 21131–21140.
  24. Chen, F.; Huang, P.; Zhu, Y.-J.; Wu, J.; Cui, D.-X. Multifunctional Eu3+/Gd3+ dual-doped calcium phosphate vesicle-like nanospheres for sustained drug release and imaging. Biomaterials 2012, 33, 6447–6455.
  25. Zhang, J.; Liu, W.; Schnitzler, V.; Tancret, F.; Bouler, J.-M. Calcium phosphate cements for bone substitution: Chemistry, handling and mechanical properties. Acta Biomater. 2014, 10, 1035–1049.
  26. Mastrogiacomo, S.; Kownacka, A.E.; Dou, W.; Burke, B.P.; de Rosales, R.T.M.; Heerschap, A.; Jansen, J.A.; Archibald, S.J.; Walboomers, X.F. Bisphosphonate Functionalized Gadolinium Oxide Nanoparticles Allow Long-Term MRI/CT Multimodal Imaging of Calcium Phosphate Bone Cement. Adv. Healthc. Mater. 2018, 7, e1800202.
  27. Rong, Z.-J.; Yang, L.-J.; Cai, B.-T.; Zhu, L.-X.; Cao, Y.-L.; Wu, G.-F.; Zhang, Z.-J. Porous nano-hydroxyapatite/collagen scaffold containing drug-loaded ADM-PLGA microspheres for bone cancer treatment. J. Mater. Sci. Mater. Med. 2016, 27, 89.
  28. Xie, L.; Wang, G.; Sang, W.; Li, J.; Zhang, Z.; Li, W.; Yan, J.; Zhao, Q.; Dai, Y. Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy. Biomaterials 2021, 269, 120638.
  29. Schwartz, C.L.; Gorlick, R.; Teot, L.; Krailo, M.; Chen, Z.; Goorin, A.; Grier, H.E.; Bernstein, M.L.; Meyers, P. Multiple drug resistance in osteogenic sarcoma: INT0133 from the Children’s Oncology Group. J. Clin. Oncol. 2007, 25, 2057–2062.
  30. Hu, J.; Jiang, Y.; Tan, S.; Zhu, K.; Cai, T.; Zhan, T.; He, S.; Chen, F.; Zhang, C. Selenium-doped calcium phosphate biomineral reverses multidrug resistance to enhance bone tumor chemotherapy. Nanomedicine 2021, 32, 102322.
  31. Takeuchi, A.; Suwanpramote, P.; Yamamoto, N.; Shirai, T.; Hayashi, K.; Kimura, H.; Miwa, S.; Higuchi, T.; Abe, K.; Tsuchiya, H. Mid- to long-term clinical outcome of giant cell tumor of bone treated with calcium phosphate cement following thorough curettage and phenolization. J. Surg. Oncol. 2018, 117, 1232–1238.
  32. Wang, Y.; Li, X.; Luo, Y.; Zhang, L.; Chen, H.; Min, L.; Chang, Q.; Zhou, Y.; Tu, C.; Zhu, X.; et al. Application of osteoinductive calcium phosphate ceramics in giant cell tumor of the sacrum: Report of six cases. Regen. Biomater. 2022, 9, rbac017.
  33. Higuchi, T.; Yamamoto, N.; Hayashi, K.; Takeuchi, A.; Kimura, H.; Miwa, S.; Igarashi, K.; Abe, K.; Taniguchi, Y.; Aiba, H.; et al. Calcium Phosphate Cement in the Surgical Management of Benign Bone Tumors. Anticancer. Res. 2018, 38, 3031–3035.
  34. Verlaan, J.J.; van Helden, W.H.; Oner, F.C.; Verbout, A.J.; Dhert, W.J.A. Balloon vertebroplasty with calcium phosphate cement augmentation for direct restoration of traumatic thoracolumbar vertebral fractures. Spine 2002, 27, 543–548.
  35. Blumenthal, D.T.; Aisenstein, O.; Ben-Horin, I.; Ben Bashat, D.; Artzi, M.; Corn, B.W.; Kanner, A.A.; Ram, Z.; Bokstein, F. Calcification in high grade gliomas treated with bevacizumab. J. Neurooncol. 2015, 123, 283–288.
  36. Kozai, D.; Ogawa, N.; Mori, Y. Redox regulation of transient receptor potential channels. Antioxid. Redox Signal. 2014, 21, 971–986.
  37. Sun, Q.; Liu, B.; Zhao, R.; Feng, L.; Wang, Z.; Dong, S.; Dong, Y.; Gai, S.; Ding, H.; Yang, P. Calcium Peroxide-Based Nanosystem with Cancer Microenvironment-Activated Capabilities for Imaging Guided Combination Therapy via Mitochondrial Ca2+ Overload and Chemotherapy. ACS Appl. Mater. Interfaces 2021, 13, 44096–44107.
  38. Yao, S.S.; Jin, B.A.; Liu, Z.M.; Shao, C.Y.; Zhao, R.B.; Wang, X.Y.; Tang, R.K. Biomineralization: From Material Tactics to Biological Strategy. Adv. Mater. 2017, 29, 19.
  39. Zhou, Y.; Zhang, J.; Dan, P.; Bi, F.; Chen, Y.; Liu, J.; Li, Q.; Gou, H.; Wu, B.; Qiu, M. Tumor calcification as a prognostic factor in cetuximab plus chemotherapy-treated patients with metastatic colorectal cancer. Anticancer. Drugs 2019, 30, 195–200.
  40. Wang, C.; Wang, X.; Zhang, W.; Ma, D.; Li, F.; Jia, R.; Shi, M.; Wang, Y.; Ma, G.; Wei, W. Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents. Adv. Mater. 2022, 34, e2107150.
  41. Zhao, R.; Wang, B.; Yang, X.; Xiao, Y.; Wang, X.; Shao, C.; Tang, R. A Drug-Free Tumor Therapy Strategy: Cancer-Cell-Targeting Calcification. Angew. Chem. Int. Ed. Engl. 2016, 55, 5225–5229.
  42. Tan, X.; Huang, J.; Wang, Y.; He, S.; Jia, L.; Zhu, Y.; Pu, K.; Zhang, Y.; Yang, X. Transformable Nanosensitizer with Tumor Microenvironment-Activated Sonodynamic Process and Calcium Release for Enhanced Cancer Immunotherapy. Angew. Chem. Int. Ed. Engl. 2021, 60, 14051–14059.
  43. Hu, H.; Xu, Q.; Mo, Z.; Hu, X.; He, Q.; Zhang, Z.; Xu, Z. New anti-cancer explorations based on metal ions. J. Nanobiotechnology 2022, 20, 457.
  44. Zhao, H.; Wang, L.; Zeng, K.; Li, J.; Chen, W.; Liu, Y.-N. Nanomessenger-Mediated Signaling Cascade for Antitumor Immunotherapy. ACS Nano 2021, 15, 13188–13199.
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Subjects: Materials Science, Biomaterials
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Xin Chen
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Huizhang Li
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Yinhua Ma
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Yingying Jiang
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Update Date: 29 Jun 2023
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