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Topic Review
Bitumen and Bitumen Modification
According to the European specification (EN 12597), bitumen is defined as a virtually involatile, adhesive, and waterproofing material derived from crude oil, or present in natural asphalt, which is completely or nearly completely soluble in toluene, and very viscous or nearly solid at ambient temperatures. It is well-accepted that the original characteristics of bitumen are highly dependent on its production and processing procedure, as well as bitumen crude oil characteristics. Good crude oils and proper distillation processes can enhance bitumen properties.
  • 1.5K
  • 17 Jun 2021
Topic Review
Bivalent Proximity-Inducing Compounds for Targeted Protein Degradation
Bivalent proximity-inducing compounds represent a novel class of small molecule therapeutics with exciting potential and new challenges. The most prominent examples of such compounds are utilized in targeted protein degradation where E3 ligases are hijacked to recruit a substrate protein to the proteasome via ubiquitination.
  • 725
  • 30 Nov 2022
Topic Review
Black Phosphorus
Black phosphorus (BP) is one of the emerging versatile nanomaterials with outstanding biocompatibility and biodegradability, exhibiting great potential as a promising inorganic nanomaterial in the biomedical field. BP nanomaterials possess excellent ability for valid bio-conjugation and molecular loading in anticancer therapy. Generally, BP nanomaterials can be classified into BP nanosheets (BPNSs) and BP quantum dots (BPQDs), and both of them can be oxidized and degraded to nontoxic phosphonates and phosphate under physiological conditions, improving their safety as a nano drug carrier in cancer therapy. In addition, BP nanomaterials can be applied as photothermal agents (PTA) for photothermal therapy (PTT) and photodynamic therapy (PDT) due to their high photothermal conversion efficiency, large extinction coefficients, and capability of producing singlet oxygen. Recently, it has been reported that BP-based phototherapy is capable of activating immune responses and alleviating the immunosuppressive tumor microenvironment by detection of T lymphocytes and various immunocytokines, indicating that BP-based nanocomposites not only serve as effective PTAs to ablate large solid tumors but also function as an immunomodulation agent to eliminate discrete tumorlets.
  • 581
  • 02 Sep 2021
Topic Review
Black Soldier Fly
The black soldier fly (BSF), Hermetia illucens Linnaeus, is a large Stratiomyidae fly (13-20 mm in size) found worldwide, but it is believed to have originated in the Americas. It is frequently found in the tropics and temperate regions throughout the world. Although adapted primarily to these regions, it can tolerate wide extremes of temperature except when ovipositing. They are considered beneficial insects and non-pests. The adult fly does not have mouthparts, stingers, or digestive organs; thus, they do not bite or sting and do not feed during its short lifespan. They feed only as larvae and are, therefore, not associated with disease transmission. BSF larvae (BSFL) are voracious eaters of a wide range of organic wastes, decomposing and returning nutrients to the soil. Additionally, BSFL is an alternative protein source for aquaculture, pet food, livestock feed, and human nutrition.
  • 37.8K
  • 25 Apr 2023
Topic Review
Block Copolymers
With the speedy progress in the research of nanomaterials, self-assembly technology has captured the high-profile interest of researchers because of its simplicity and ease of spontaneous formation of a stable ordered aggregation system. The self-assembly of block copolymers can be precisely regulated at the nanoscale to overcome the physical limits of conventional processing techniques. This bottom-up assembly strategy is simple, easy to control, and associated with high density and high order, which is of great significance for mass transportation through membrane materials.
  • 894
  • 15 Nov 2022
Topic Review
Block Copolymers as Proficient Templates in Drug Delivery
Polymeric-based nanomaterials have exhibited wonderful properties due to their fabrication ability using various technologies. These have been of immense interest as nanocarriers in the design of pharmaceuticals and in the refining of drug delivery systems; therefore, they offer a suitable tool for the release of hydrophobic drugs and bioactive agents.
  • 237
  • 04 Dec 2023
Topic Review
Blood Pressure Sensors
In our unique transdisciplinary approach, we studied the fundamentals of blood pressure and examined its measuring modalities while focusing on their clinical use and sensing principles to identify material functionalities. Then, we carefully reviewed various categories of functional materials utilized in sensor building blocks allowing for comparative analysis of the performance of a wide range of materials throughout the sensor operational-life cycle. Not only this provides essential data to enhance the materials’ properties and optimize their performance, but also, it highlights new perspectives and provides suggestions to develop the next generation pressure sensors for clinical use.
  • 2.8K
  • 10 Apr 2021
Topic Review
Blood-Brain Barrier: Functionalised Chitosan
The major impediment to the delivery of therapeutics to the brain is the presence of the blood-brain barrier (BBB). The BBB allows for the entrance of essential nutrients while excluding harmful substances, including most therapeutic agents; hence, brain disorders, especially tumors, are very difficult to treat. Chitosan is a well-researched polymer that offers advantageous biological and chemical properties, such as mucoadhesion and ease of functionalization. Chitosan-based nanocarriers (CsNCs) establish ionic interactions with the endothelial cells, facilitating the crossing of drugs through the BBB by adsorptive mediated transcytosis. This process is further enhanced by modifications of the structure of chitosan, owing to the presence of reactive amino and hydroxyl groups. Finally, by permanently binding ligands or molecules, such as antibodies or lipids, CsNCs have shown a boosted passage through the BBB, in both in vivo and in vitro studies which will be discussed in this review.
  • 1.3K
  • 21 Nov 2020
Topic Review
Blood–Brain Barrier Penetrating Nanoplatforms
The current knowledge and advancements on various nanoplatforms (NF) and the use of nanoparticles for successful cross of BBB to treat the brain-related disorders such as brain tumors, Alzheimer’s disease, Parkinson’s disease, and stroke. 
  • 642
  • 12 Jan 2021
Topic Review
Blue Diamond
Blue diamond is a type of diamond which exhibits all of the same inherent properties of the mineral except with the additional element of blue color in the stone. They are colored blue by trace amounts of boron that contaminate the crystalline lattice structure. Blue diamonds belong to a subcategory of diamonds called fancy color diamonds, the generic name for diamonds that exhibit intense color. Blue diamonds range in grade from Flawless to Included, just as in the case of white diamonds.
  • 458
  • 04 Nov 2022
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