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Topic Review
Chitosan as a Biomaterial
Chitosan remarkable properties have aroused the interest of applying this material in several biomedical applications, such as tissue engineering, wound dressing, drug delivery, and cancer treatment, what has aroused the interest of this review to gather the state-of-the-art concerning this polysaccharide when used as a biomaterial, providing information about its characteristics, chemical modifications, and applications.
  • 748
  • 25 Nov 2020
Topic Review
Nanoengineering to Modulate Macrophage Polarization
Modulation of macrophage plasticity is emerging as a successful strategy in tissue engineering (TE) to control the immune response elicited by the implanted material. Indeed, one major determinant of success in regenerating tissues and organs is to achieve the correct balance between immune pro-inflammatory and pro-resolution players. In recent years, nanoparticle-mediated macrophage polarization towards the pro- or anti-inflammatory subtypes is gaining increasing interest in the biomedical field. In TE, despite significant progress in the use of nanomaterials, the full potential of nanoparticles as effective immunomodulators has not yet been completely realized. This work discusses the contribution that bioactive inorganic nanoparticles may give to TE applications, helping native or synthetic scaffolds to direct macrophage polarization for skeletal muscle regeneration. 
  • 747
  • 20 Oct 2020
Topic Review
Review of Ionic Liquids Toxicity
Ionic liquids (more accurately room-temperature ionic liquids (RTILs)) can be defined as materials composed of organic or inorganic cations (like imidazolium or pyridinium) and anions (e.g., nitrate, acetate, tetrafluoroborate, dicyanamide, bis(trifluoromethylsulfonyl)imide and lactate) that are liquid at or below 100 °C. The number of possible combinations of a cation and anion is estimated to reach 106, making it theoretically possible to synthesize an IL targeted for a specific application or property.
  • 747
  • 29 Jun 2021
Topic Review
Hydrophilic Modification of Dialysis Membranes
The dialyzer is the core element in the hemodialysis treatment of patients with end-stage kidney disease (ESKD). During hemodialysis treatment, the dialyzer replaces the function of the kidney by removing small and middle-molecular weight uremic toxins, while retaining essential proteins. Meanwhile, a dialyzer should have the best possible hemocompatibility profile as the perpetuated contact of blood with artificial surfaces triggers complement activation, coagulation and immune cell activation, and even low-level activation repeated chronically over years may lead to undesired effects. During hemodialysis, the adsorption of plasma proteins to the dialyzer membrane leads to a formation of a secondary membrane, which can compromise both the uremic toxin removal and hemocompatibility of the dialyzer. Hydrophilic modifications of novel dialysis membranes have been shown to reduce protein adsorption, leading to better hemocompatibility profile and performance stability during dialysis treatments.
  • 747
  • 07 Nov 2022
Topic Review
Lead-Free Perovskite Solar Cells
Next-generation renewable energy sources and perovskite solar cells have revolutionised photovoltaics research and the photovoltaic industry. However, the presence of toxic lead in perovskite solar cells hampers their commercialisation. Lead-free tin-based perovskite solar cells are a potential alternative solution to this problem; however, numerous technological issues must be addressed before the efficiency and stability of tin-based perovskite solar cells can match those of lead-based perovskite solar cells.
  • 747
  • 18 Aug 2021
Topic Review
Alginate Microparticles for Food, Pharmaceutical and Cosmetic Applications
Alginates are the most widely used natural polymers in the pharmaceutical, food and cosmetic industries. Usually, they are applied as a thickening, gel-forming and stabilizing agent. Moreover, the alginate-based formulations such as matrices, membranes, nanospheres or microcapsules are often used as delivery systems. Alginate microparticles (AMP) are biocompatible, biodegradable and nontoxic carriers, applied to encapsulate hydrophilic active substances, including probiotics.
  • 747
  • 21 Oct 2022
Topic Review
Sustainable Valorisation of Agri-Food Wastes
In the upcoming years, the world will face societal challenges arising, in particular, from the impact of climate change and the inefficient use of natural resources, in addition to an exponential growth of the world population, which according to the United Nations (UN) estimations will be 9.8 billion in 2050. This increasing trend requires optimized management of natural resources with the use of value-added waste and a significant reduction in food loss and food waste. Moreover, the recent pandemic situation, COVID-19, has contributed indisputably. Along with the agri-food supply chain, several amounts of waste or by-products are generated.
  • 746
  • 28 Dec 2022
Topic Review
Types of Scaffolds in Cartilage Regeneration
There are two main types of scaffolds: natural polymers and synthetic polymers. On the one hand, natural polymers are proteins (e.g., collagen, SF) and polysaccharides (e.g., Alg, CS, and HA derivatives). Natural polymers already have a long history of application in wound treatment. They are the closest substances to human tissue and show biocompatibility and biodegradability without toxic byproducts, and their technologies and properties have been widely investigated. Furthermore, in the form of hydrogels, they can retain a great amount of water. However, natural polymers are normally poor in mechanical strength. On the other hand, synthetic polymers have different properties. They allow the better control of formation, surface morphology, mechanical strength and physicochemical properties than natural polymers. Among them, poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(lactic-co-glycolic acid) (PLGA), poly(ε-caprolactone) (PCL) and poly(urethanes) (PU) are the most popular candidates in osteochondral regeneration. The limitations of synthetic polymers are poor hydrophilicity, proinflammatory degradation byproducts, and unmatched degradation rates. It is noticeable that these two types of polymers are not independent.
  • 746
  • 08 Sep 2022
Topic Review
Hovenia dulcis Thumberg
Hovenia dulcis Thunberg is an herbal plant, belonging to the Rhamnaceae family, widespread in west Asia, USA, Australia and New Zealand, but still almost unknown in Western countries. H. dulcis has been described to possess several pharmacological properties, such as antidiabetic, anticancer, antioxidant, anti-inflammatory and hepatoprotective, especially in the hangover treatment, validating its use as an herbal remedy in the Chinese Traditional Medicine. These biological properties are related to a variety of secondary metabolites synthesized by the different plant parts. Root, bark and leaves are rich of dammarane-type triterpene saponins; dihydrokaempferol, quercetin, 3,3′,5′,5,7-pentahydroflavone and dihydromyricetin are flavonoids isolated from the seeds; fruits contain mainly dihydroflavonols, such as dihydromyricetin (or ampelopsin) and hovenodulinol, and flavonols such as myricetin and gallocatechin; alkaloids were found in root, barks (frangulanin) and seeds (perlolyrin), and organic acids (vanillic and ferulic) in hot water extract from seeds. Finally, peduncles have plenty of polysaccharides which justify the use as a food supplement.
  • 745
  • 02 Mar 2021
Topic Review
Poly(aryl-ether-ketone) Materials for Application in Dentistry
Poly(aryl-ether-ketone) materials (PAEKs), a class of high-performance polymers comprised of polyetheretherketone (PEEK) and polyetherketoneketone (PEKK). PEEK is a restorative dental material widely used for prosthetic frameworks due to its superior physical, mechanical, aesthetic, and handling features. Meanwhile, PEKK is a semi-crystalline thermoplastic embraced in the additive manufacturing market.
  • 745
  • 16 May 2023
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