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Topic Review
AI for Biomarker Analysis in Early Cancer Detection
Governments worldwide have prioritized multicancer early detection (MCED) for the better management of cancers. Artificial intelligence (AI) is a promising technology to enhance the performance of MCED. In the field of MCED, applying AI has also proven to be efficient in improving diagnostic performance. Harnessing AI has become a must-use technology in analyzing MCED data because MCED tools typically target tens of analytical targets. 
  • 160
  • 29 Feb 2024
Topic Review
AI in SARS-CoV-2 outbreak
Artificial Intelligence (AI) and Machine Learning (ML) have expanded their utilization in different fields of medicine. During the SARS-CoV-2 outbreak, AI and ML were also applied for the evaluation and/or implementation of public health interventions aimed to flatten the epidemiological curve. 
  • 800
  • 29 May 2021
Topic Review
AI/Big Data in Healthcare
Multimorbidity refers to the coexistence of two or more chronic diseases in one person. Therefore, patients with multimorbidity have multiple and special care needs. However, in practice it is difficult to meet these needs because the organizational processes of current healthcare systems tend to be tailored to a single disease. To improve clinical decision making and patient care in multimorbidity, a radical change in the problem-solving approach to medical research and treatment is needed. In addition to the traditional reductionist approach, we propose interactive research supported by artificial intelligence (AI) and advanced big data analytics. Such research approach, when applied to data routinely collected in healthcare settings, provides an integrated platform for research tasks related to multimorbidity. This may include, for example, prediction, correlation, and classification problems based on multiple interaction factors. However, to realize the idea of this paradigm shift in multimorbidity research, the optimization, standardization, and most importantly, the integration of electronic health data into a common national and international research infrastructure is needed. Ultimately, there is a need for the integration and implementation of efficient AI approaches, particularly deep learning, into clinical routine directly within the workflows of the medical professionals.
  • 504
  • 14 Sep 2021
Topic Review
Air Pollution Affects Placental DNA Methylation
The Developmental Origins of Health and Disease (DOHaD) concept postulates that in utero exposures influence fetal programming and health in later life. Throughout pregnancy, the placenta plays a central role in fetal programming; it regulates the in utero environment and acts as a gatekeeper for nutrient and waste exchange between the mother and the fetus. Maternal exposure to air pollution, including heavy metals, can reach the placenta, where they alter DNA methylation patterns, leading to changes in placental function and fetal reprogramming. In this entry, we explore the current knowledge on placental DNA methylation changes associated with prenatal air pollution (including heavy metals) exposure and highlight its effects on fetal development and disease susceptibility.
  • 762
  • 15 Nov 2021
Topic Review
Air Pollution and Polluting Particles
Air pollution is a real public health problem, it being one of the five most common causes of mortality in developing countries. Pollution is universally widespread, already a matter of public interest, so that, although intuitive, it is difficult to connect the two. The particles found in the air that researchers breathe, regardless of their origin, can attack the body in different ways, causing inflammation, and triggering a true cascade of phenomena that end up attacking the central nervous system and other organs.
  • 351
  • 29 Jun 2022
Topic Review
Air Pollution on Chronic Rhinosinusitis and Asthma
Redox regulation participates in the control of various aspects of metabolism. Reactive oxygen and nitrogen species participate in many reactions under physiological conditions. When these species overcome the antioxidant defense system, a distressed status emerges, increasing biomolecular damage and leading to functional alterations. Air pollution is one of the exogenous sources of reactive oxygen and nitrogen species. Ambient airborne particulate matter (PM) is important because of its complex composition, which includes transition metals and organic compounds. Once in contact with the lungs’ epithelium, PM components initiate the synthesis of inflammatory mediators, macrophage activation, modulation of gene expression, and the activation of transcription factors, which are all related to the physiopathology of chronic respiratory diseases, including cancer. 
  • 408
  • 08 Feb 2023
Topic Review
Air Pollution on the Eye
Air pollution is inevitably the result of human civilization, industrialization, and globalization. It is composed of a mixture of gases and particles at harmful levels. Particulate matter (PM), nitrogen oxides (NOx), and carbon dioxides (CO2) are mainly generated from vehicle emissions and fuel consumption and are the main materials causing outdoor air pollution. Exposure to polluted outdoor air has been proven to be harmful to human eyes. On the other hand, indoor air pollution from environmental tobacco smoking, heating, cooking, or poor indoor ventilation is also related to several eye diseases, including conjunctivitis, glaucoma, cataracts, and age-related macular degeneration (AMD).
  • 528
  • 15 Feb 2022
Topic Review
Air-Pollution on Disease Initiation
      Air pollution is a major environmental risk to health and a global public health concern. In 2016, according to the World Health Organization (WHO), ambient air pollution in cities and rural areas was estimated to cause 4.2 million premature deaths. It is estimated that around 91% of the world’s population lives in places where air pollution exceeds the limits recommended by the WHO. Sources of air pollution are multiple and context-specific. Air pollution exposures are established risk factors for development and adverse health outcomes in many respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), or lung cancer. However, possible associations between air pollution and idiopathic pulmonary fibrosis (IPF) have not been adequately studied and air pollution seems to be an underrecognized risk factor for IPF.
  • 726
  • 14 Apr 2021
Topic Review
Alcohol Consumption Patterns
Excessive alcohol consumption has negative effects not only on the drinkers’ health but also on others around them. Alcohol consumption can be attributed to a range of demographic and social factors, namely access to alcohol outlets, age exposure, familial background, socioeconomic background, and religious influence. Easier access to the substance can be associated with the more frequent consumption of alcohol among adults, young adults, and adolescents in general, and it may be associated with higher levels of harmful consumption, as well as more harmful effects in life events for women. Adolescents exposed to alcohol at a young age, regardless of gender, drank more, but their drinking habits changed as they grew older. Family background influences alcohol dependence, including family stability, parental authority over early access to alcohol, and family lifestyle, which influences alcohol dependence, notably mother drinking tolerance and habit of consuming alcohol throughout pregnancy. The level of education, employment, type of profession, and monthly income can have an impact on alcohol consumption. There is a link between high religiosity and fewer alcohol-related problems, less binge drinking, and less alcohol consumption frequency for any gender.
  • 398
  • 19 Jul 2022
Topic Review
Alcohol Use in Pregnancy
Understanding the factors that contribute to women’s alcohol use in pregnancy is of critical importance to women's health and prevention of Fetal Alcohol Spectrum Disorder (FASD). Alcohol use in pregnancy is influenced by a range of contextual and structural factors, including poverty, histories of trauma and violence, physical and mental health concerns, normalization of alcohol in social networks, sociocultural and economic vulnerabilities and disadvantage, and child welfare involvement. Therefore, beyond supporting individual change, it is necessary to address a range of structural and systemic issues through the adoption of emerging gender-, trauma-, cultural, and equity-informed interventions. 
  • 484
  • 24 Sep 2021
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