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Topic Review
Influence of Sunshine Exposure on Public Mental Health
External environments, including natural sunlight, have a significant impact on public mental health. The results showed that exposure to sunlight, spending leisure time in green spaces, and physical activity each had a positive impact on people’s mental health, including depression, anxiety, and stress states. Specifically, moderate physical activity in an external environment with sunlight exposure or green space was found to be an important factor. 
  • 384
  • 10 Mar 2022
Topic Review
Risk-Reducing Bilateral Salpingo-Oophorectomy
Risk-reducing bilateral salpingo-oophorectomy (RRBSO) is the gold standard preventative option for BRCA mutation carriers at high risk for ovarian and breast cancer. RRBSO involves the surgical removal of both ovaries, as well as fallopian tubes, as fallopian tubes are increasingly being recognized as the site of origin for the most common and lethal form of ovarian cancer, high-grade serous ovarian cancer. Guidelines from the National Comprehensive Cancer Network (NCCN) reccomend people with BRCA1 mutations to indergo RRBSO between the ages of 35 to 40 and upon completion of childbearing. Since the onset of ovarian cancer among BRCA2 mutations carriers is approximately 8 to 10 years later than in BRCA1 mutations carriers, the recommended timing of RRBSO is delayed to ages 40 to 45. Despite the effectiveness of undergoing RRBSO at the recommended age, it also induces immediate surgical menopause with an abrupt and significant decline in levels of sex hormones. As a result, surgical menopause is associated with various adverse physical, mental, and cognitive health outcomes. 
  • 384
  • 09 Feb 2023
Topic Review
Neglected Human Systemic Mycoses Diagnosis
Systemic mycoses have been viewed as neglected diseases and they are responsible for deaths and disabilities around the world. Rapid, low-cost, simple, highly-specific and sensitive diagnostic tests are critical components of patient care, disease control and active surveillance. 
  • 384
  • 29 Jun 2022
Topic Review
Promoting Physical Activity among Workers
Insufficient physical activity (PA) has been identified as a leading risk factor for premature and all-cause death, as well as non-communicable diseases. Employees, especially those with low occupational PA, are more vulnerable to physical inactivity, and studies in this population are scarce. However, employees may receive benefits for both health and work productivity from PA. Therefore, well-designed behavior change studies to promote PA in employees are urgently needed, especially during the COVID-19 pandemic. Intervention mapping (IM) was a useful tool to develop, implement, and evaluate behavior change interventions. 
  • 383
  • 08 Nov 2022
Topic Review
Hyaluronic Acid in Musculoskeletal Rehabilitation
Hyaluronic acid (HA) naturally occurs as a biopolymer in the human body, primarily in connective tissues like joints and skin. Functioning as a vital element of synovial fluid, it lubricates joints, facilitating fluid movement and diminishing bone friction to protect articular well-being. Its distinctive attributes encompass notable viscosity and water retention capacities, ensuring flexibility and absorbing shock during motion. Furthermore, HA has gained significant attention for its potential benefits in various medical applications, including rehabilitation. Ongoing research explores its properties and functions, especially its biomedical applications in several clinical trials, with a focus on its role in improving rehabilitation outcomes. But the clinical and biochemical implications of HA in musculoskeletal rehabilitation have yet to be fully explored.
  • 383
  • 18 Dec 2023
Topic Review
Urological Manifestations of Systemic Vasculitides
Vasculitides are specific inflammations of the blood vessel wall that can take place in any organ system of the human body. They may occur as a primary process (primary systemic vasculitides, PSV) or may be secondary to another underlying disease.
  • 383
  • 20 Dec 2021
Topic Review
Genetic Counselling for Rare Diseases in Spain
Genetic Counseling is essential for providing personalized information and support to patients with Rare Diseases (RD). Unlike most other developed countries, Spain does not recognize geneticists or genetic counsellors as healthcare professionals. Thus, patients with RD face not only challenges associated with their own disease but also deal with lack of knowledge, uncertainty, and other psychosocial issues arising as a consequence of diagnostic delay.
  • 383
  • 24 Jan 2022
Topic Review
Dysfunction of Biliary Sphincter of Oddi
Biliary Sphincter of Oddi dysfunction (SOD) is one of the main causes of post-cholecystectomy pain. Biliary SOD is classified into three types according to Milwaukee classification, based on clinical presentation as well as laboratory and/or imaging abnormalities. As a functional disorder, SOD is classified according to Rome IV criteria. Currently, patients with post-cholecystectomy pain and SOD are mostly diagnosed by the Rome IV criteria. The management of SOD most often involves non-pharmacologic treatment, and high-level evidence supports sphincterotomy in type 1 and 2 SOD. Emerging high-quality data show no effect of sphincterotomy for patients with type 3 SOD. However, ERCP with biliary sphincterotomy is associated with post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis rates from 10% to 15%.
  • 383
  • 30 Aug 2023
Topic Review
Ontology-Based Parkinson’s Disease Monitoring and Alerting with PHKG-GNNs
In the realm of Parkinson’s Disease (PD) research, the integration of wearable sensor data with personal health records (PHR) has emerged as a pivotal avenue for patient alerting and monitoring. The complex domain of PD patient care was delved into, with a specific emphasis on harnessing the potential of wearable sensors to capture, represent and semantically analyze crucial movement data and knowledge. The primary objective is to enhance the assessment of PD patients by establishing a robust foundation for personalized health insights through the development of Personal Health Knowledge Graphs (PHKGs) and the employment of personal health Graph Neural Networks (PHGNNs) that utilize PHKGs. The objective is to formalize the representation of related integrated data, unified sensor and PHR data in higher levels of abstraction, i.e., in a PHKG, to facilitate interoperability and support rule-based high-level event recognition such as patient’s missing dose or falling. This is an extension of researchers' previous related work, presents the Wear4PDmove ontology in detail and evaluates the ontology within the development of an experimental PHKG. Furthermore, the integration and evaluation of PHKG within the implementation of a Graph Neural Network (GNN) are focused on. The importance of integrating PD-related data for monitoring and alerting patients with appropriate notifications are emphasized. These notifications offer health experts precise and timely information for the continuous evaluation of personal health-related events, ultimately contributing to enhanced patient care and well-informed medical decision-making. Finally, a novel approach for integrating personal health KGs and GNNs for PD monitoring and alerting solutions is proposed.
  • 383
  • 18 Mar 2024
Topic Review
No and Low Alcohol Products
Reducing the alcoholic strength in beverages as a strategy to reduce harmful alcohol use has been proposed by multilateral institutions such as the World Health Organization and governments worldwide. Different industrial and artisanal techniques are used to achieve low-alcohol content beverages. Therefore, regulations regarding the content of alcohol in beverages and strategies to monitor compliance are important, because they are the main reason for classification of the beverages and are central to their categorization and market labelling. Furthermore, analytical techniques with adequate sensitivity as low as 0.04% vol are necessary to determine the alcohol ranges necessary for classification. 
  • 382
  • 29 Sep 2022
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