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Topic Review
Social Connectedness
Poor social connectedness has long been recognised as a significant threat to both physical and mental health, particularly for older people. Numerous studies examining the health impacts of loneliness and isolation have demonstrated an association with negative outcomes such as increased mortality, cognitive decline, anxiety and depression and cardiovascular disease. However, with the rapid onset of the SARS-CoV-2 (otherwise known as COVID-19) virus in early 2020 came an additional threat to those already vulnerable to loneliness—enforced physical isolation. Confinement to the home was particularly important for the health of those in older age due to the increased mortality risk from the virus for that section of the population.
  • 394
  • 13 Nov 2023
Topic Review
Remotely-Based Pulmonary Rehabilitation
Despite numerous benefits, traditional Pulmonary Rehabilitation (PR) as a resource remains underutilized in chronic lung disease. Less than 3% of eligible candidates for PR attend one or more sessions after hospitalization due to many barriers, including the ongoing COVID-19 pandemic. Emerging alternative models of PR delivery such as home-based PR, tele-rehabilitation, web-based PR, or hybrid models could help address these barriers. Numerous studies have tested the feasibility, safety, and efficacy of these methods, but there is wide variability across studies and methods. We conducted a literature review to help determine if these alternative delivery methods watered down the effectiveness of PR. 
  • 394
  • 13 Dec 2021
Topic Review
Neonatal Sepsis and Hemostasis
Neonatal sepsis is considered critical for a significant increase in neonatal morbidity and mortality among hospitalized neonates. Neonatal sepsis, in most cases, coexists with coagulopathy, which can prove to be life-threatening.
  • 394
  • 08 Feb 2022
Topic Review
Immunosenescence in Cerebral Small Vessel Disease
Cerebral small vessel disease (CSVD) is one of the most important causes of vascular dementia. Immunosenescence and inflammatory response, with the involvement of the cerebrovascular system, constitute the basis of this disease. Immunosenescence identifies a condition of deterioration of the immune organs and consequent dysregulation of the immune response caused by cellular senescence, which exposes older adults to a greater vulnerability. A low-grade chronic inflammation status also accompanies it without overt infections, an “inflammaging” condition. The correlation between immunosenescence and inflammaging is fundamental in understanding the pathogenesis of age-related CSVD (ArCSVD). The production of inflammatory mediators caused by inflammaging promotes cellular senescence and the decrease of the adaptive immune response. Vice versa, the depletion of the adaptive immune mechanisms favours the stimulation of the innate immune system and the production of inflammatory mediators leading to inflammaging. Furthermore, endothelial dysfunction, chronic inflammation promoted by senescent innate immune cells, oxidative stress and impairment of microglia functions constitute, therefore, the framework within which small vessel disease develops: it is a concatenation of molecular events that promotes the decline of the central nervous system and cognitive functions slowly and progressively.
  • 394
  • 05 Sep 2022
Topic Review
Therapy for Patients with Hereditary Angioedema during Pregnancy
Hereditary angioedema (HAE) is a rare, inherited disease caused by a deficiency (HAE-1) or lack of functional (HAE-2) C1 inhibitor protein. The symptoms present with mucocutaneous swelling of various organ systems, such as the respiratory and gastrointestinal systems, which can manifest as stridor and abdominal pain, respectively. HAE can present with increased frequency and severity of attacks during the pregnancy and lactation period. This is thought to be due to hormonal changes, which may trigger HAE attacks. The management of this condition in pregnant and lactating patients can be challenging for providers due to disease rarity and the lack of data regarding the management of this specific population. 
  • 394
  • 18 Aug 2023
Topic Review
Exercise and Bone Health in Cancer
Bone health is often threatened in cancer patients. Bone metastasis and osteoporosis frequently occur in patients with cancer and may lead to different skeletal-related events, which may negatively affect patients’ quality of life and are associated with high mortality risk. Physical exercise has been recognized as a potential adjunctive strategy in the cancer setting to improve physical function as well as treatment-related side effects.
  • 393
  • 23 Dec 2022
Topic Review
Health Plans for Suicide Prevention in Spain
Suicide is a serious health problem affecting people of all ages and in all countries. Suicide prevention, listed by the World Health Organisation (WHO) as a global imperative, has grown in importance in recent years to become a priority task in global public health. Suicide death rates are high, with an estimated 800,000 deaths by suicide each year.
  • 393
  • 15 Jun 2022
Topic Review
Air Pollution and Polluting Particles
Air pollution is a real public health problem, it being one of the five most common causes of mortality in developing countries. Pollution is universally widespread, already a matter of public interest, so that, although intuitive, it is difficult to connect the two. The particles found in the air that researchers breathe, regardless of their origin, can attack the body in different ways, causing inflammation, and triggering a true cascade of phenomena that end up attacking the central nervous system and other organs.
  • 393
  • 29 Jun 2022
Topic Review
Antibiotics in Animal Origin Food
Antibiotics are antimicrobial substances formed by or obtained from microorganisms that kill or inhibit the growth of other microorganisms. Antibiotics were first approved for use in livestock by the US Food and Drug Administration (FDA) in 1951. The European Union has forbidden the use of antibiotics as growth promoters since 2006. Its abusive use leads to the presence of antibiotic residues (AR) in foods of animal origin which is associated with antibiotic resistance.
  • 393
  • 01 Mar 2023
Topic Review
MIS-C Associated with COVID-19
This study aimed to achieve a better understanding of the epidemiological and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) following coronavirus disease 2019 (COVID-19).
  • 392
  • 19 Jul 2021
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