Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Therapeutic Response-Related Ferroptosis Regulators in Bladder Cancer
Ferroptosis, an iron-dependent form of regulated cell death characterized by the accumulation of lipid peroxidation, has been reported to regulate tumorigenesis, metastasis, drug resistance and the immune response. However, the potential roles of ferroptosis regulators in the progression of bladder cancer (BLCA) remain unknown. We systematically evaluated the multidimensional alteration landscape of ferroptosis regulators in BLCA and checked if their expression correlated with the ferroptosis index. Using least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox regression, a seven ferroptosis regulator signature was constructed. We validated the prognostic and predictive accuracy of this signature in five independent datasets and established a nomogram to predict the overall survival (OS) and risk of death of BLCA patients. Moreover, the risk score was associated with tumor progression and antitumor immunity-related pathways. Furthermore, the relative antitumor immune cell infiltration level was negatively correlated with the risk score, and the tumor mutation burden was higher in the low-risk group, which might be useful for predicting immunotherapy efficacy. The Tumor Immune Dysfunction and Exclusion (TIDE) database and IMvigor210 cohort with immunotherapy efficacy results were used to confirm the prediction function of the risk score. Furthermore, the ferroptosis regulator signature could also reflect the chemotherapy sensitivity of BLCA. Ferroptosis might play a role in precision individualized chemotherapy and immunotherapy. This entry highlights the crucial clinical implications of ferroptosis and will help with developing personalized therapeutic strategies for BLCA patients
  • 442
  • 13 Dec 2021
Topic Review
SARS-CoV-2 Mutational Pattern in Greece
From the 2500 clinical specimens, 220 were tested positive for SARS-CoV-2 indicating a prevalence of 8.8% among suspected cases. The RT-PCR Ct (Cycle threshold) Value ranged from 19 to 25 which corresponds to medium to high copy numbers of the virus in the positive samples.
  • 442
  • 21 Jan 2022
Topic Review
Stress of Moving Homes
Moving homes has long been considered stressful, but how stressful is it? Researches try to utilise a micro-level individual dataset in the New Zealand Government’s Integrated Data Infrastructure (IDI) to reconstruct the Social Readjustment Rating Scale (SRRS) and thereby measure stress at a whole-of-population level. The effects of residential mobility on people’s mental well-being in the context of their stress-of-moving homes are examined.
  • 442
  • 21 Nov 2022
Topic Review
Static Stretching Exercises
The utility of flexibility as a standard component of physical fitness has recently been questioned, sparking a heated debate among scientists. Rsearchers conducted a narrative review of the existing knowledge and concluded that flexibility deserves to be further considered as a standard component of physical fitness. This is based on the findings that in addition to flexibility, long-term static stretching training induces positive effects on muscle strength, muscle power, and muscle hypertrophy, irrespective of age and sex. There are also indications that long-term static stretching training could mitigate the risk of injury. Furthermore, promising evidence shows that combining resistance training with static stretching exercises constitutes an effective approach benefiting muscle strength and hypertrophy more than resistance training alone. Overall, researchers would not support the recent suggestion that flexibility should be retired as a standard component of physical fitness and researchers would advocate for a continuous emphasis on the prescription of stretching exercises.
  • 442
  • 10 Feb 2023
Topic Review
Resistance Training for People with COVID-19
Among different physical exercise models that might help to prevent and treat COVID-19-related conditions, resistance training (RT) might be particularly relevant. Among its benefits, RT can be adapted to be performed in many different situations, even with limited space and equipment, and is easily adapted to an individual’s characteristics and health status.
  • 441
  • 28 Jun 2022
Topic Review
Protective Textiles against Biological Threats
The development of protective clothing is crucial nowadays, as there are increased levels of harmful biological threats, both for military forces and civilians.
  • 440
  • 29 Apr 2022
Topic Review
Carbon Footprints of Active and Non-Active Transport Modes
Carbon footprint is defined as the exclusive total amount of carbon dioxide emissions that are directly or indirectly caused by an activity or accumulated over the lifespan of a product. This definition suggests that a carbon footprint can be generated directly or indirectly by an individual through daily behaviours. 
  • 440
  • 14 Nov 2023
Topic Review
Qualitative Evidence for Return-to-Work
Chronic musculoskeletal pain (CMSP) (i.e., pain duration >3 months) such as chronic neck/shoulder and back pain or generalized widespread pain (including fibromyalgia (FM)) has a prevalence from 10.4% to 20% among adults.
  • 440
  • 19 Apr 2021
Topic Review
Marketing of Healthcare Systems
By using market orientation, the managers of healthcare systems could stimulate the innovation, the efficiency of funds allocation and the quality of medical services. The results will lead to a better quality of population life and to an increasing of life expectancy. 
  • 440
  • 16 Jun 2021
Topic Review
School gardening activities and Obesity
School gardening activities (SGA) combined with physical activities (PA) may improve childhood dietary intake and prevent overweight and obesity. This study aims to evaluate the effect of SGA combined with PA on children’s dietary intake and anthropometric outcomes. We searched studies containing randomized controlled trials up to January 2021 in Web of Science, PubMed, Cochrane Library, and the EBSCO database on this topic for children aged 7 to 12 years.
  • 440
  • 13 Aug 2021
  • Page
  • of
  • 183
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
ScholarVision Creations
Feedback