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Topic Review
Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) is an aggressive breast type of cancer with no expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2). It is a highly metastasized, heterogeneous disease that accounts for 10–15% of total breast cancer cases with a poor prognosis and high relapse rate within five years after treatment compared to non-TNBC cases. 
  • 864
  • 11 Oct 2021
Topic Review
The Banyan (NGO)
The Banyan is an non-governmental organization based in Chennai, India was founded in 1993 by Vandana Gopikumar and Vaishnavi Jayakumar to cater to the mentally ill and homeless women in the city. Over the past two decades, has expanded to offer a range of comprehensive mental health solutions for men and women who are either homeless, or living in a state of abject poverty. This includes emergency care and critical time interventions offered across 2 hospital based settings, and one shelter for homeless persons with psychosocial disabilities, operated in collaboration with the Corporation of Chennai under the National Urban Livelihoods Mission (NULM), reaching out to 162 individuals in distress at any given point of time. Over 3400 individuals have accessed these services since 1993. The Banyan's NALAM programme offers well-being oriented outpatient clinics and community based mental health care in both urban and rural areas. These clinics provide free of charge and mental health and social care services, address distress, common mental disorders and severe mental disorders. They are offered across 15 service access points, reaching out to a population of approximately 7 lakhs. NALAM has reached out to over 10,000 individuals and has a current active registry of 2000 individuals. For those who experience high support needs, The Banyan offers a range of inclusive living options, over 200 individuals with moderate to severe mental health issues, today live in communities & homelike environments with supportive services across 6 districts in 3 States (Tamil Nadu, Kerala, Maharashtra). The Banyan's sister organisation - The Banyan Academy of Leadership in Mental Health (BALM), was founded in 2007, and works towards consolidating findings and experiences from The Banyan, and disseminating it across multiple stakeholders within the mental health and development spaces. BALM works on building practice based evidence and contributing to a knowledge base, that aids in addressing treatment and care gaps, particularly in the context of vulnerable individuals and groups. It uses capacity building, education programmes (diploma, masters’, and PhD programmes) in collaboration with the Tata Institute of Social Sciences (TISS), research, collaborative work (with civil society organisations, local governments, disability movements, mental health user-caregiver groups, and Central and State Government) and construction of think tanks, as strategies to influence progressive policies and plans.
  • 864
  • 10 Oct 2022
Topic Review
The Related Metabolic Diseases and Treatments of Obesity
Obesity is a chronic disease characterized by the abnormal or excessive accumulation of body fat. Obesity is commonly associated with other metabolic disorders, such as type 2 diabetes, non-alcoholic fatty liver disease, cardiovascular diseases, chronic kidney disease, and cancers. Factors such as a sedentary lifestyle, overnutrition, socioeconomic status, and other environmental and genetic conditions can cause obesity. Many molecules and signaling pathways are involved in the pathogenesis of obesity. 
  • 863
  • 01 Sep 2022
Topic Review
Phytochemicals Constituent of Cimicifuga racemosa
Women’s health is an imminent concern worldwide, but it remains an ignored segment of research in most developing countries, and is yet to take the center stage in even developed nations. Some exclusive female health concerns revolve around both pathological and physiological aspects. These gender-specific maladies include breast, cervical, and ovarian cancers, and physiological concerns such as menopause and osteoporosis, which are often coexistent. Recently, women’s health issues, including postmenopausal syndrome, have attracted the attention of researchers and practitioners alike, opening newer pharmaceutical research and clinical avenues. Although not counted as a disease, postmenopausal syndrome (PMS) is a female health phenomenon underpinned by hormonal depletion. Enhanced life expectancy in women has added to their suffering, and pharmacological interventions are needed. Amongst the available treatment modalities, the use of numerous botanicals has emerged as an efficient health management tool for women. Cimicifuga racemosa (CR or Black Cohosh) is a plant/herb which has been traditionally exploited and extensively used by women.
  • 862
  • 18 Mar 2022
Topic Review
Vitamin A and Pregnancy
Vitamin A is a crucial micronutrient for pregnant women and their fetuses. In addition to being essential for morphological and functional development and for ocular integrity, vitamin A exerts systemic effects on several fetal organs and on the fetal skeleton. 
  • 859
  • 09 Aug 2022
Topic Review
Climate Change and Vector-Borne Diseases in China
Vector-borne diseases are among the most rapidly spreading infectious diseases and are widespread all around the world. In China, many types of vector-borne diseases have been prevalent in different regions, which is a serious public health problem with significant association with meteorological factors and weather events. Under the background of current severe climate change, the outbreaks and transmission of vector-borne diseases have been proven to be impacted greatly due to rapidly changing weather conditions. 
  • 857
  • 08 Apr 2022
Topic Review
Glioblastoma Cells
Glioblastoma multiforme (GBM) is the most common brain cancer in adults. GBM starts from a small fraction of poorly differentiated and aggressive cancer stem cells (CSCs) responsible for aberrant proliferation and invasion. Due to extreme tumor heterogeneity, actual therapies provide poor positive outcomes, and cancers usually recur. Therefore, alternative approaches, possibly targeting CSCs, are necessary against GBM.
  • 854
  • 31 Mar 2022
Topic Review
Health, Economic and Social Challenges in COVID-19 Pandemic
The COVID-19-pandemic-related health, economic and social crises are leading to huge challenges for all spheres of human life across the globe. Various challenges highlighted by this pandemic include, but are not limited to, the need for global health cooperation and security, better crisis management, coordinated funding in public health emergencies, and access to measures related to prevention, treatment, and control. 
  • 854
  • 10 May 2022
Topic Review
Magnesium and Zinc: Critical Biomarkers for Skin Expansion
Tissue engineering and regenerative medicine have been transforming the medical field, providing new methods for repairing and regenerating damaged skin. Zinc and magnesium have been identified as key elements in tissue scaffolds for skin expansion. The mechanical properties, biocompatibility, and cellular responsiveness of tissue scaffolds are significantly influenced by these factors. Both elements have been incorporated to scaffolds using a variety of techniques, increasing their capacity for skin expansion. Smart 4D BIOdegradable METallic Shape-shifting Implants For Dynamic Tissue Restoration Horizon Europe project No 101047008 HORIZON-EIC-2021-PATHFINDEROPEN-01  
  • 851
  • 18 Apr 2023
Topic Review
Sustainability-Sport-Physical Activity
The present study is a synthesizing analysis of international literature on correlations between sustainability, sport, and physical activity. The study of sustainability is considered essential in modern research; its multidisciplinary approach relies on sports science and sports economics as well. There are several aspects of sustainability that are closely associated with health and health preservation; the beneficial effect of exercise on health is also widely known. For the analysis of this complex matter, our current study relied on secondary sources, and besides exploring specialist literature, it also illustrates and analyzes related statistical data. Our results highlight the correlations between living environment and physical activity, the importance of increasing individual commitment towards sustainability and using green spaces for exercising, as well as questions on social and environmental development in relation to physical activity. The study revealed the existence of highly complex links between physical environment, physical activities, and sustainability. The results section of our study provides a brief summary on the possible ways of making people physically active. Increasing physical activity is of paramount importance for achieving the objectives formulated in relation to sustainability.
  • 849
  • 19 Feb 2021
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