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Topic Review
Biography
Topic Review
BoNT-A Injection for Spinal Cord Injury
Lower urinary tract symptoms (LUTS), such as urgency, urinary incontinence, and/or difficulty voiding, hamper the quality of life (QoL) of patients with spinal cord injury (SCI). If not managed adequately, urological complications, such as urinary tract infection or renal function deterioration, may further deteriorate the patient’s QoL. Botulinum toxin A (BoNT-A) injection within the detrusor muscle or urethral sphincter yields satisfactory therapeutic effects for treating urinary incontinence or facilitating efficient voiding.
197
23 May 2023
Topic Review
Brain Immunoinformatics
Breakthrough advances in informatics of the last decade have thoroughly influenced the field of immunology. In particular, the immunoinformatics of the central neural system is referred to as neuroimmunoinformatics (NII). This interdisciplinary overview on NII is addressed to bioscientists and computer scientists. We delineate the dominating trajectories and field-shaping achievements and elaborate on future directions using a bridging language and terminology. Computation, varying from linear modeling to complex deep learning approaches, fuels neuroimmunology through three core directions. Firstly, by providing big-data analysis software for high-throughput methods such as next-generation sequencing and genome-wide association studies. Secondly, by designing models for the prediction of protein morphology, functions, and protein-protein interactions. Finally, NII boosts the output of quantitative pathology by enabling the automatization of tedious processes such as cell counting, tracing, and arbor analysis. Deep sequencing classifies microglia in “sensotypes” to accurately describe the versatility of immune responses to physiological and pathological challenges, as well as to experimental conditions such as xenografting and organoids. NII opts to individualize treatment strategies, personalize disease prognosis and treatment response.
560
28 Mar 2022
Topic Review
Brain Neurodegeneration and Cognitive Deficits after Cardiac Arrest
Cardiac arrest occurs as a result of a sudden stop of the heartbeat and its mechanical activity, which causes cessation of systemic circulation and blood flow in the brain, which triggers global brain ischemia. Brain neuropathology after cardiac arrest includes primary ischemic injury and secondary reperfusion injury, which occur sequentially, acutely during cardiac arrest and resuscitation, and chronically in the post-resuscitation stag.
442
29 Feb 2024
Topic Review
Breakthrough Infections in Measles Elimination
Measles is one of the most contagious diseases known to man. Despite the existence of a safe and effective live attenuated vaccine, measles can appear in vaccinated individuals. Paradoxically, breakthrough cases increase as vaccination coverage in the general population rises. In measles endemic areas, breakthrough cases represent less than 10% of total infections, while in areas with high vaccination coverage these are over 10% of the total. Two different vaccination failures have been described: primary vaccination failure, which consists in the complete absence of humoral response and occurs in around 5% of vaccinated individuals; and secondary vaccination failure is due to waning immunity or incomplete immunity and occurs in 2–10% of vaccinees. Vaccination failures are generally associated with lower viral loads and milder disease (modified measles) since vaccination limits the risk of complicated disease. Vaccination failure seems to occur between six and twenty-six years after the last vaccine dose administration.
737
15 Aug 2022
Topic Review
Breast Cancer Detection
Breast cancer is one the main death causes for women worldwide, as 16% of the diagnosed malignant lesions worldwide are its consequence. In this sense, it is of paramount importance to diagnose these lesions in the earliest stage possible, in order to have the highest chances of survival. While there are several works that present selected topics in this area, none of them present a complete panorama, that is, from the image generation to its interpretation.
607
27 Jul 2022
Topic Review
Breast Density and Pre-Trained Convolutional Neural Network
Breast density describes the amount of fibrous and glandular tissue in a breast compared with the amount of fatty tissue. The breast density is assigned to one of four classes in the mammogram report based on the ACR BI-RADS standard. Convolutional Neural Network (CNN) are a type of artificial neural network usually used for classification and computer vision tasks. Therefore, CNNs are considered efficient tools for medical imaging classification.
453
21 Jun 2022
Topic Review
Breastfeeding on Food Allergies
Breastfeeding is the preferred method of infant feeding and its establishment is one of the primary goals for the infant. Allergic diseases are common in childhood, with increased morbidity. Food allergies are also associated with a strong negative impact on health-related quality of life and is a major public health problem. In addition, maternal exclusion of common allergens during pregnancy and/or lactation suggests that supplementation with regular cow’s milk formula during the first week of life should be avoided. Breast milk contains many active immune factors, such as cytokines, inflammatory mediators, signaling molecules and soluble receptors, which may also reduce the risk of allergic disease.
317
29 Jun 2023
Topic Review
Breathing Exercises for Improving Influencing Cognitive Decline
Stroke is caused by a fall in blood supply to the brain or due to cerebral hemorrhage and is the most common cerebrovascular condition. With the increase in the average life expectancy as a result of lifestyle improvements and advances in health care, the number of patients with stroke has seen an upward trend. Furthermore, studies have shown a possible association between the coronavirus disease (COVID-19) and acute cerebrovascular diseases such as ischemic stroke, hemorrhagic stroke, and cerebral venous thrombosis. With the continuing COVID-19 pandemic, a steep increase in stroke incidence is therefore likely.
468
30 May 2022
Topic Review
Bruxism in Down Syndrome Children
Bruxism is defined as “a repetitive jaw-muscle activity that is characterized by clenching or grinding of the teeth and/or by bracing or thrusting of the mandible,” and is distinguished into sleep bruxism (SB) or awake bruxism (AB), depending on its circadian phenotype. Its role in children and adolescents with Down syndrome is still unclear. Therefore, this study aims to conduct a narrative review of the literature about bruxism in children and adolescents with Down syndrome to identify the prevalence, risk factors, and possible treatments of this disorder.
770
31 Mar 2021
Topic Review
Buildings’ Sustainability after COVID-19
The concept of sustainability, or sustainable development, was introduced in 1987 through the UN Brundtland Report, in which it is defined as "development that meets the needs of the present without compromising the ability of future generations to meet their own needs". The link between COVID-19 and sustainability is made up of a variety of psycho-sociological and perceptual aspects, such as the fact that the occupancy pattern of buildings is one of the determining factors in assessing the energy performance and sustainability of buildings.
340
26 Feb 2024
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