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Topic Review
Vitamin D—Innate and Acquired Immunity
Globally, vitamin D deficiency is a significant public health problem—a pandemic—that has overtaken iron deficiency as the most common nutritional deficiency in the world. Vitamin D deficiency is associated with many chronic diseases and increases the risk of acute and worsened chronic infections. Both vitamin D and [25(OH]D: calcifediol) and its active form, 1,25-dihydroxyvitamin D [1,25(OH)2D: calcitriol], play critical roles in protecting humans from invasive pathogens, reducing risks of autoimmunity, and maintaining better health. Conversely, low 25(OH)D status increases susceptibility to infections and developing autoimmunity. Individuals obtain optimal results by maintaining serum 25(OH)D concentrations above 50 ng/mL (125 nmol/L) (above 40 ng/mL in the population): this also minimizes community outbreaks and autoimmune disorders. In over 97.5% of people, this can be achieved through daily sun exposure (except in countries far from the equator during winter) or taking between 5,000 and 8,000 IU vitamin D supplements daily (average, ~70 to 90 IU/kg body weight). Only those with gastrointestinal malabsorption, obesity, or on medications that increase catabolism of vitamin D, and a few specific disorders require higher intake.
  • 990
  • 06 Sep 2023
Topic Review
Food Insecurity Is Associated with Cognitive Function
Food insecurity (FI) has negative implications across the life course that include poor health outcomes among both children and adults. However, the behavioral mechanisms by which FI impacts health behaviors are not clear. 
  • 984
  • 25 Nov 2021
Topic Review
Sport in the School Environment
With regard to school-related physical activities, extended educational sports activities become more important in all-day schools. These activities include supervised sports classes after lessons, unsupervised opportunities during lunchtime, and free physical activities during recess, as well as before and after lessons. 
  • 984
  • 25 Mar 2022
Topic Review
Physical Exercise in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a major health problem, and its prevalence has increased in recent years. Diet and exercise interventions are the first-line treatment options. The goal is to understand the complex pathophysiology underlying exercise interventions with the potential to prevent and treat NAFLD.
  • 982
  • 26 Nov 2020
Topic Review
Bee Pollen
Bee pollen is a natural cocktail of floral nectar, flower pollen, enzymes, and salivary secretions produced by honeybees. Bee pollen is one of the bee products most enriched in proteins, polysaccharides, polyphenols, lipids, minerals, and vitamins. It has a significant health and medicinal impact and provides protection against many diseases, including diabetes, cancer, infectious, and cardiovascular. Bee pollen is commonly promoted as a cost-effective functional food. 
  • 981
  • 30 Jul 2022
Topic Review
Probiotics and Synbiotics on Hirsutism
Probiotics and synbiotics are known to have beneficial effects on human health and disease. Hirsutism, a disorder that is characterised by the presence of coarse terminal hairs in a male-like pattern, is usually caused by elevated androgen levels in blood plasma. This disorder is usually ob-served in PCOS women and it is linked to insulin resistance (IR). Although idiopathic hirsutism (IH) is not shown to have excess androgen production from the ovarian and adrenal glands, in-creased 5α-reductase in peripheral tissues and insulin resistance are common observations.
  • 978
  • 27 Jan 2021
Topic Review
Opportunistic Premise Plumbing Pathogens
Opportunistic premise plumbing pathogens (OPPP) are microorganisms that are native to the plumbing environment and that present an emerging infectious disease problem. They share characteristics, such as disinfectant resistance, thermal tolerance, and biofilm formation. The colonisation of domestic water systems presents an elevated health risk for immune-compromised individuals who receive healthcare at home.
  • 973
  • 29 Apr 2022
Topic Review
Application of Sol–Gels for Treatment of Gynaecological Conditions
Approaches for effective and sustained drug delivery to the female reproductive tract (FRT) for treating a range of gynaecological conditions remain limited. The development of versatile delivery platforms, such as soluble gels (sol–gels) coupled with applicators/devices, holds considerable therapeutic potential for gynaecological conditions. Sol–gel systems, which undergo solution-to-gel transition, triggered by physiological conditions such as changes in temperature, pH, or ion composition, offer advantages of both solution- and gel-based drug formulations. Furthermore, they have potential to be used as a suitable drug delivery vehicle for other novel drug formulations, including micro- and nano-particulate systems, enabling the delivery of drug molecules of diverse physicochemical character. Hence, such systems are are of profound significance in delivering the drugs to various parts of FRT for optimal treatment of various gynecological conditions which was not achievable using conventional drug delivery technologies.
  • 971
  • 24 Feb 2022
Topic Review
Structural Violence and Health-Related Outcomes
In recent years, there has been a revival of the term “structural violence (SV)” which was coined by Johan Galtung in the 1960s in the context of Peace Studies. “Structural violence” refers to social structures—economic, legal, political, religious, and cultural—that prevent individuals, groups and societies from reaching their full potential. In the European context, very few studies have investigated health and well-being using an SV perspective.
  • 969
  • 13 Aug 2021
Topic Review
Carbon Dots-Mediated Fluorescent Scaffolds
Regeneration of damaged tissues or organs is one of the significant challenges in tissue engineering and regenerative medicine. Many researchers have fabricated various scaffolds to accelerate the tissue regeneration process. However, most of the scaffolds are limited in clinical trials due to scaffold inconsistency, non-biodegradability, and lack of non-invasive techniques to monitor tissue regeneration after implantation. Recently, carbon dots (CDs) mediated fluorescent scaffolds are widely explored for the application of image-guided tissue engineering due to their controlled architecture, light-emitting ability, higher chemical and photostability, excellent biocompatibility, and biodegradability.
  • 963
  • 08 Jun 2021
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