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Topic Review
Collagen Injectables for Aesthetic and Regenerative Medicine Applications
Soft tissues diseases significantly affect patients quality of life and usually require targeted, costly and sometimes constant interventions. With the average lifetime increase, a proportional increase of age-related soft tissues diseases has been witnessed. Due to this, the last two decades have seen a tremendous demand for minimally invasive one-step resolutive procedures. Intensive scientific and industrial research has led to the recognition of injectable formulations as a new advantageous approach in the management of complex diseases that are challenging to treat with conventional strategies. Among them, collagen-based products are revealed to be one of the most promising among bioactive biomaterials-based formulations. Collagen is the most abundant structural protein of vertebrate connective tissues and, because of its structural and non-structural role, is one of the most widely used multifunctional biomaterials in the health-related sectors, including medical care and cosmetics. Indeed, collagen-based formulations are historically considered as the “gold standard” and from 1981 have been paving the way for the development of a new generation of fillers. A huge number of collagen-based injectable products have been approved worldwide for clinical use and have routinely been introduced in many clinical settings for both aesthetic and regenerative surgery. 
  • 1.1K
  • 06 May 2023
Topic Review
Psychomotor Agitation
The Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) defines agitation as an excessive motor activity associated with a feeling of inner tension. Motor activity is usually non-productive and repetitious and can include behaviors such as pacing, fidgeting, hand wringing, pulling one’s clothes, and an inability to sit still. Even if aggression and violence are not core agitation features, a progression in agitation severity can lead to aggressive and violent behaviors. At the first International Experts’ Meeting on Agitation, agitation was defined as "a state where patients cannot remain still or calm, characterized by internal features such as hyperresponsiveness, racing thoughts, and emotional tension; and external ones, mainly motor and verbal hyperactivity, and communication impairment".
  • 1.1K
  • 13 May 2021
Topic Review
Variables Impact Healthcare Outcome Measures and Data Management
The rapid growth of technology, digitalization of health records, and unprecedented data management of healthcare information enable healthcare providers and researchers to assist in healthcare quality improvement and community health outcomes. Data management and potential variables affect the performance of healthcare measures. Data analytics enables healthcare providers and researchers to evaluate, monitor performance, and track healthcare quality across the continuum of patient care. The data type is an attribute of data that tells the aggregator or interpreter how the programmer intends to use the data.
  • 1.1K
  • 05 Jul 2022
Topic Review Peer Reviewed
COVID-19 and Psychological Impact
The worldwide mental health burden associated to COVID-19. The psychological symptoms associated to COVID-19 can originate from three different sources: lockdowns, pandemic life and virus infection (both COVID-19 and post COVID-19 condition). Within the psychological symptoms it can be found: anxiety, depression, post-traumatic stress, fatigue and cognitive impairment (i.e., ’brain fog’, mental slowness, deficits in attention, executive functioning, working memory, learning, articulation, and/or psychomotor coordination). Plus, two psychological conditions associated to the COVID-19 pandemic have been coined so far by the World Health Organization: pandemic fatigue and post COVID-19 condition. The increase of psychological symptoms both in the general population and in frontline workers (especially health-care workers) generates an unprecedented number of psychological patients and it challenges national mental health systems. 
  • 1.1K
  • 13 Apr 2022
Topic Review
Hyperacusis in Autism Spectrum Disorders
Decreased Sound Tolerance Disorders (DSTD) are routinely observed in autism spectrum disorder (ASD). The most common types of DSTD are hyperacusis and misophonia. Hyperacusis is a class of decreased sound tolerance disorders in which a negative or incongruous reaction is triggered from exposure to sounds that are not described as threatening or uncomfortable by a neurotypical individual. These reactions are in response to general sounds, rather than specific sounds (such as chewing and sniffling), as would be the case with misophonia. Hyperacusis can affect an individual at various degrees depending on the severity. It can impact one’s emotional wellbeing, sleep, concentration, and can cause anxiety.
  • 1.1K
  • 11 Nov 2021
Topic Review
Fall Risk Assessment Scales
Falls are recognized globally as a major public health problem. Although the elderly are the most affected population, it should be noted that the pediatric population is also very susceptible to the risk of falling. The fall risk approach is the assessment tool. There are different types of tools used in both clinical and territorial settings. 
  • 1.1K
  • 24 Jun 2021
Topic Review
Carbonic Anhydrase Inhibitors and Epilepsy
Carbonic anhydrases (CAs) are a group of ubiquitously expressed metalloenzymes that catalyze the reversible hydration/dehydration of CO2/HCO3. Thus, they are involved in those physiological and pathological processes in which cellular pH buffering plays a relevant role. The inhibition of CAs has pharmacologic applications for several diseases.
  • 1.1K
  • 02 Nov 2021
Topic Review
Advanced Glycation End Products
Diabetes mellitus (DM) is considered one of the most massive epidemics of the twenty-first century due to its high mortality rates caused mainly due to its complications; therefore, the early identification of such complications becomes a race against time to establish a prompt diagnosis. The research of complications of DM over the years has allowed the development of numerous alternatives for diagnosis. Among these emerge the quantification of advanced glycation end products (AGEs) given their increased levels due to chronic hyperglycemia, while also being related to the induction of different stress-associated cellular responses and proinflammatory mechanisms involved in the progression of chronic complications of DM. Additionally, the investigation for more valuable and safe techniques has led to developing a newer, noninvasive, and effective tool, termed skin fluorescence (SAF).
  • 1.1K
  • 10 Aug 2021
Topic Review
Particle-Bound Mercury Characterization
Particulate Bound Hg (PBM) consists of all airborne particulate containing Hg, including both stable condensed and gaseous forms adsorbed on atmospheric particulate matter (PM); it is operationally sampled and quantified by pulling air through a glass fiber or a quartz filter. PBM usually includes all those particles with a diameter <2.5 μm, even if its characterization depends on the pore size of the filter used for its collection. The accurate dimensional characterization is then essential to estimate the dry deposition of PBM, as well as any other particulate pollutant; the particles diameters directly influence gravitational sedimentation and the PBM residence time in the atmosphere. In addition, PBM chemical speciation, as well as for the other Hg forms, is fundamental to understand PBM bioavailability and therefore the effects on human .
  • 1.1K
  • 05 Jul 2021
Topic Review
Galactomyces Ferment Filtrate
Galactomyces ferment filtrate (GFF) is such a functional ingredient. Its use originated from the empirical observation that the hands of sake brewers who deal with yeast fermentation retain a beautiful and youthful appearance. Consequently, skincare products based on GFF are widely used throughout the world.
  • 1.1K
  • 15 Nov 2022
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