Topic Review
Microneedle-Based Glucose Sensor Platform
Significant advanced have been made in exploiting microneedle-based (MN-based) diabetes devices for minimally invasive wearable biosensors and for continuous glucose monitoring. Within this emerging class of skin-worn MN-based sensors, the ISF can be utilized as a rich biomarker source to diagnose diabetes. While initial work of MN devices focused on ISF extraction, the research trend has been oriented toward developing in vivo glucose sensors coupled with optical or electrochemical (EC) instrumentation.
  • 511
  • 17 Aug 2022
Topic Review
Aortic Stenosis and Cardiac Amyloidosis
The association between aortic stenosis (AS) and cardiac amyloidosis (CA) is more frequent than expected. Albeit rare, CA, particularly the transthyretin (ATTR) form, is commonly found in elderly people. ATTR-CA is also the most prevalent form in patients with AS. These conditions share pathophysiological, clinical and imaging findings, making the diagnostic process very challenging.
  • 354
  • 16 Aug 2022
Topic Review
Eating Behaviors of People with Chronic Stress
Psychological stressors frequently occur in modern society, and are associated with general anhedonic traits (inability to experience pleasure) and altered eating behavior. As eating behavior is largely motivated by a desire for pleasure, the Food Pleasure Scale (FPS) was introduced as a new research tool for investigating aspects of pleasure from food-related experiences. 
  • 349
  • 16 Aug 2022
Topic Review
Current Status of Internet Gaming Disorder
The World Health Organization recognizes internet gaming disorder (IGD) as a disorder that causes problems in daily life as a result of excessive interest in online games. The causes of IGD have become more apparent. Because of prolonged exposure to games, the mechanisms controlling the reward system, such as the prefrontal cortex, limbic system, and amygdala of the cerebrum, do not function properly in IGD. This mechanism is similar to that of various behavioral addictions, such as gambling addiction. IGD is particularly risky in children and adolescents because it easily causes brain dysfunction, especially in the developing brain.
  • 587
  • 15 Aug 2022
Topic Review
Lateral Flow Assays Combat Antimicrobial Resistant
Antimicrobial resistance (AMR) is today universally recognised as a global threat because of the rapid emergence and dissemination of resistant bacteria and genes among humans, animals, and the environment on a global scale. AMR thus represents a heavy burden for healthcare systems all over the world. ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa et Enterobacter spp.) combined with antibiotic resistance have greatly increased the risk of morbidity and mortality, especially in ICU settings. Lateral flow assays (LFA) are inexpensive, rapid, and efficient tools that are easy to implement in the routine workflow of laboratories as new first-line tests against AMR with bacterial colonies, and in the near future directly with biological media.
  • 534
  • 15 Aug 2022
Topic Review
Breakthrough Infections in Measles Elimination
Measles is one of the most contagious diseases known to man. Despite the existence of a safe and effective live attenuated vaccine, measles can appear in vaccinated individuals. Paradoxically, breakthrough cases increase as vaccination coverage in the general population rises. In measles endemic areas, breakthrough cases represent less than 10% of total infections, while in areas with high vaccination coverage these are over 10% of the total. Two different vaccination failures have been described: primary vaccination failure, which consists in the complete absence of humoral response and occurs in around 5% of vaccinated individuals; and secondary vaccination failure is due to waning immunity or incomplete immunity and occurs in 2–10% of vaccinees. Vaccination failures are generally associated with lower viral loads and milder disease (modified measles) since vaccination limits the risk of complicated disease. Vaccination failure seems to occur between six and twenty-six years after the last vaccine dose administration. 
  • 757
  • 15 Aug 2022
Topic Review
Cultural Safety for LGBTQIA+ People
Although the concept of "cultural safety" as its origins in indigenous nursing care, there is support and rationale for applying this concept for LGBTQIA+ people as a population who experience health disparities due to barriers to access equitable care. Building on Mukerjee and colleagues' 5 "P" tenets (partnerships, personal activities of daily living, prevention of harm, patient centering, and purposeful self-reflection), reviewed studies on components of culturally safe care for LGBTQIA+ people revealed five themes: power-enhancing care; inclusive healthcare institutions; continuous education and research; promotion of visibility; and individualised care.
  • 499
  • 12 Aug 2022
Topic Review
Mirror Neuron System to Treat Gait
Gait is affected from the early stages of the disease and its worsening runs parallel to the progression of the pathology where three phases could be established. Treatment of gait are focused on medication, brain surgery, and physiotherapy. The more used medication is levodopa, and regarding brain surgery, deep brain stimulation (DBS) in the subthalamic nuclei is the most used option. Both treatments lead to an improvement in spatiotemporal parameters of gait and freezing of gait (FOG), obtaining good results from the beginning up to two years after the intervention, but becoming less evident with the progression of parkinson's disease.
  • 401
  • 12 Aug 2022
Topic Review
Self-Testing to Reduce HIV in Transgender Women
So far, the rate of HIV-positive people who do not know their sero-status is about 14% and the percentage is higher among transgender women (TGW). They represent one of the most vulnerable groups to infection. HIV self-testing (HIVST) may be a way to reduce transmission of the virus. 
  • 250
  • 10 Aug 2022
Topic Review
Physiotherapy Interventions in the Elderly with Neurological Disorders
Physiotherapy deals with the support and promotion of physical recovery after physical injuries or neurological events and conditions. The degeneration of the neuromuscular system over time is an inevitable part of the aging process, a condition that makes physical therapy necessary in the elderly, especially those with additional neurological disorders (NDs). In this context, physiotherapists often have to evaluate and treat elderly patients with loss of cognitive function from aging as well as balance disorders such as cerebral palsy (and movement disorders), degenerative diseases such as Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, polyneuropathy (e.g., diabetic neuropathy or Guillain–Barré syndrome), peripheral nerve injuries, and acute cases such as patients recovering from stroke and, recently, elders recovering from COVID-19. Most of the therapeutic approaches for neurological rehabilitation include basic elements such as promoting normal movement, controlling abnormal muscle tone, and facilitating function. Furthermore, neurological physiotherapy adopts a problem-based individualized approach, as determined from a thorough evaluation of a patient’s health status. Therefore, the treatment goals for a person recovering from a stroke may be vastly different among patients with similar NDs but different health history. Thus, the treatment approaches used depend on the individual patient and their symptoms and physiotherapy’s rehabilitation goals, so a variety of tools and standard approaches can be applied.
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  • 10 Aug 2022
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