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Topic Review
Management of Lung Toxicity with T-DXd in Canada
Ongoing advances in precision cancer therapy have increased the number of molecularly targeted and immuno-oncology agents for a variety of cancers, many of which have been associated with a risk of pulmonary complications, among the most concerning being drug-induced interstitial lung disease/pneumonitis (DI-ILD). As the number of patients undergoing treatment with novel anticancer agents continues to grow, DI-ILD is expected to become an increasingly significant clinical challenge. Trastuzumab deruxtecan (T-DXd) is an antibody–drug conjugate targeting human epidermal growth factor receptor 2 that is gaining widespread use in the metastatic breast cancer setting and is undergoing exploration for other oncologic indications. ILD/pneumonitis is an adverse event of special interest associated with T-DXd, which has potentially fatal consequences if left untreated and allowed to progress. When identified in the asymptomatic stage (grade 1), T-DXd-related ILD can be monitored and treated effectively with the possibility of treatment continuation. Delayed diagnosis and/or treatment, however, results in progression to grade 2 or higher toxicity and necessitates immediate and permanent discontinuation of this active agent. Strategies are, therefore, needed to optimize careful monitoring during treatment to ensure patient safety and optimize outcomes.
  • 151
  • 19 Sep 2023
Topic Review
Aortic Valve Stenosis and Cancer
Aortic valve stenosis and malignancy frequently coexist and share the same risk factors as atherosclerotic disease. Data reporting the prognosis of patients with severe aortic stenosis and cancer are limited. Tailoring the correct and optimal care for cancer patients with severe aortic stenosis is complex.
  • 217
  • 18 Sep 2023
Topic Review
Rehabilitation in Older Adults Affected by Immobility Syndrome
Individual mobility deficit in older adults induces a variety of medical conditions, diminishing their functional capacity in pursuing activities of daily living. In immobility syndrome patients, such conditions are prone to further deterioration through a drastically reduced scope of physical activity, owing mostly to poor self-motivation and the monotonous character of conventional rehabilitation regimens. As evidenced by published research, virtual reality technology solutions in rehabilitation management actually add significantly to patients’ self-motivation, while promoting their active involvement in therapy through visual, auditory, and kinaesthetic stimuli.
  • 212
  • 18 Sep 2023
Topic Review
Care of Patients with Rheumatic Diseases
In order to provide the highest quality of care to patients, nurses working at the advanced level are expected to develop knowledge and to initiate services and practices carried out in collaboration with other professionals. In 2018, the European League Against Rheumatism (EULAR) updated its recommendations for the role of the nurse in the management and care of patients with rheumatic conditions. 
  • 244
  • 15 Sep 2023
Topic Review
Contamination of Pathogens on Shellfish
Bivalve molluscan shellfish have been consumed for centuries. Being filter feeders, they may bioaccumulate some microorganisms present in coastal water, either naturally or through the discharge of human or animal sewage. Despite regulations set up to avoid microbiological contamination in shellfish, human outbreaks still occur.
  • 158
  • 15 Sep 2023
Topic Review
Endothelial Function Evaluation on Pregnant COVID-19 Patients
Pregnancy with SARS-CoV-2 infection can raise the risk of many complications, including severe COVID-19 and maternal–fetal adverse outcomes. Additionally, endothelial damage occurs as a result of direct SARS-CoV-2 infection, as well as immune system, cardiovascular, and thrombo-inflammatory reactions. The endothelium is the key regulator of vascular homeostasis, as it determines vascular tone, smooth muscle cell proliferation, vessel wall inflammation, and platelet aggregation.
  • 274
  • 14 Sep 2023
Topic Review
Bidirectional Relationship between Gut Dysbiosis, Anxiety and Depression
Inflammatory bowel disease represents one of the most life-altering gastrointestinal pathologies, with its multifactorial nature and unclear physiopathology. The most relevant clinical forms, ulcerative colitis and Crohn’s disease, clinically manifest with mild to severe flares and remission periods that alter the patient’s social, familial and professional integration. The chronic inflammatory activity of the intestinal wall determines severe modifications of the local environment, such as dysbiosis, enteric endocrine, nervous and immune system disruptions and intestinal wall permeability changes. These features are part of the gastrointestinal ecosystem that modulates the bottom-to-top signaling to the central nervous system, leading to a neurobiologic imbalance and clinical affective and/or behavioral symptoms. The gut-brain link is a bidirectional pathway and psychological distress can also affect the central nervous system, which will alter the top-to-bottom regulation, leading to possible functional digestive symptoms and local inflammatory responses. In the middle of this neuro-gastrointestinal system, the microbiome is a key player, as its activities offer basic functional support for both relays.
  • 212
  • 14 Sep 2023
Topic Review
Phenolic Compounds in Medicinal Plants
Unlike other secondary metabolites, phenolic compounds are found in almost all plant cells. They hold functional significance not at the cell level, but at the level of the whole plant. The central enzyme of phenylpropanoid metabolism (phenylalanine ammonia-lyase) is inducible: due to the induction of the expression of coding genes, its activity increases sharply under the influence of stress factors. 
  • 240
  • 12 Sep 2023
Topic Review
Interaction between Mealtime and Circadian Hormones
Achieving synchronization between the central and peripheral body clocks is essential for ensuring optimal metabolic function. Meal timing is an emerging field of research that investigates the influence of eating patterns on our circadian rhythm, metabolism, and overall health.
  • 2.5K
  • 12 Sep 2023
Topic Review
Role of Non-Coding RNAs in Tumor Microenvironment
Non-coding RNAs (ncRNAs) are a group of molecules critical for cell development and growth regulation. Cancer creates and expands the Tumor Microenvironment, which in turn supports cancer progression.
  • 152
  • 11 Sep 2023
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