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All Topic Review Biography
Topic Review
Root Canal Irrigation Methods
According to contemporary dental standards, the primary goal of endodontic therapy is the chemo-mechanical cleaning of the complex root canal system. Watering root canals with approved solutions and activating them are essential parts of this operation.
  • 343
  • 08 Sep 2023
Topic Review
Cancers: Costs in Relation to Disability-Adjusted Life Years
Cancer represents a major health issue, concerning both the clinical burden (in terms of morbidity and mortality) and the consequent economic implications. With regard to the latter, Disability-Adjusted Life Years (DALYs) are often used to measure the burden of disease since they are a compound unit encompassing both disability and mortality, but substantial heterogeneity occurs when they are translated to monetary value. Each DALY due to cancer has shown to cost, on average, around 9000 USD in high- and upper-middle income countries, although this computation can be strongly influenced by fluctuations depending on cancer type and other parameters (e.g., country, prices). Moreover, the cost per cancer-related DALY has been found to be, on average, 32% (95% CI: 24–42%) of the corresponding countries’ gross domestic product (GDP) per capita, which implies that the use of a priori established parameters, such as GDP or the value of a statistical life (VSL), might lead to presenting rough estimates highly different (even threefold) from what emerges a posteriori, after directly retrieving figures and/or building models out of available data.
  • 342
  • 27 May 2022
Topic Review
Endothelial Glycocalyx and Neonatal Sepsis
Sepsis carries a substantial risk of morbidity and mortality in newborns, especially preterm-born neonates. Endothelial glycocalyx (eGC) is a carbohydrate-rich layer lining the vascular endothelium, with important vascular barrier function and cell adhesion properties, serving also as a mechano-sensor for blood flow. eGC shedding is recognized as a fundamental pathophysiological process generating microvascular dysfunction, which in turn contributes to multiple organ failure and death in sepsis.
  • 342
  • 18 Jan 2023
Topic Review
Isoniazid Preventive Therapy for Tuberculosis among HIV Patients
Tuberculosis (TB) is a major cause of morbidity and mortality in people living with HIV (PLWHIV). Isoniazid preventive therapy (IPT) prevents TB in PLWHIV, but estimates of its effects and actual implementation vary across countries. PLHIV who were on IPT, independently or simultaneously with ART, were less likely to develop TB than those without IPT. IPT interventions had a significant association with improved CD4 count and reduced all-cause mortality. IPT was less effective in people with advanced HIV infection. The major factors influencing IPT implementation and uptake were stock-outs, fear of developing isoniazid-resistant TB, patient’s refusal and non-adherence, and improper counseling and low commitment of HIV clinical care providers. IPT alone or in combination with ART significantly reduces the incidence of TB and mortality in PLHIV in Ethiopia than those without IPT. More research on safety is needed, especially on women with HIV who receive a combination of IPT and ART. 
  • 342
  • 19 Jan 2023
Topic Review
Biomarkers in Monitoring Radiotherapy Toxicity
Radiotherapy (RT) is a major part of cancer treatment. The reported variability in patient response to this modality can interfere with the continuation of best-possible care, promote side effects, and lead to long-term morbidity. Tools to predict a patient’s response to radiation could be highly useful in improving therapeutic outcomes while minimizing unnecessary and toxic exposure to radiation.
  • 342
  • 30 Nov 2023
Topic Review
Genomic Classifier and Its Role in Supporting MDD
Interstitial lung diseases (ILDs) are a group of heterogeneous diseases characterized by inflammation and/or fibrosis of the lung interstitium, leading to a wide range of clinical manifestations and outcomes. Over the years, the literature has demonstrated the increased diagnostic accuracy and confidence associated with a multidisciplinary approach (MDA) in assessing diseases involving lung parenchyma. This approach was recently emphasized by the latest guidelines from the American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Latin American Thoracic Association for the diagnosis of ILDs.
  • 341
  • 08 Aug 2023
Topic Review
Spermatozoon Effect on Embryo Development
The intracytoplasmic sperm injection (ICSI) technique was invented to solve severe male infertility due to altered sperm parameters. It is applied worldwide for the treatment of couple infertility. ICSI is performed with any available spermatozoon from surgery or ejaculated samples, whatever are the sperm motility, morphology or quantity. The causes of male infertility are crucial in building a competent spermatozoa that will contribute to normal embryonic development and healthy offspring.
  • 341
  • 28 Jan 2023
Topic Review
Exercise Timing on Fat Oxidation during Exercise
Due to increasingly diverse lifestyles, exercise timings vary between individuals: before breakfast, in the afternoon, or in the evening. The endocrine and autonomic nervous systems, which are associated with metabolic responses to exercise, show diurnal variations. Moreover, physiological responses to exercise differ depending on the timing of the exercise. The postabsorptive state is associated with greater fat oxidation during exercise compared to the postprandial state. The increase in energy expenditure persists during the post-exercise period, known as “Excess Post-exercise Oxygen Consumption”.
  • 341
  • 15 Mar 2023
Topic Review
Relationship between the Gut Virome and Metabolic Pathologies
The human gastrointestinal tract contains large communities of microorganisms that are in constant interaction with the host, playing an essential role in the regulation of several metabolic processes. Human adenovirus infection was identified as a significant risk factor for the progression of nonalcoholic fatty liver disease (NAFLD). Furthermore, in liver cirrhosis, gut virome (GV) alterations correlate with cirrhosis progression. The most widely investigated matter is the relationship between the GM and intestinal diseases, primarily inflammatory bowel disease (IBD), although there is also a potential relation between GV and type 1 diabetes (T1D), type 2 diabetes (T2D), obesity, hypertension, malnutrition and low growth rate, metabolic syndrome, liver diseases, colorectal cancer (CRC), melanoma, cognitive maintenance, and cerebral ischemia.
  • 340
  • 31 May 2023
Topic Review
Biomaterial Scaffolds Applied for Spinal Cord Injury
Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological deficit and social and financial burdens. The advancements in biomaterial technology, combined with stem cell therapy or other regenerative therapy, can now accelerate the progress of promising novel therapeutic strategies from bench to bedside. Various types of approaches to regeneration therapy for SCI have been combined with the use of supportive biomaterial scaffolds as a drug and cell delivery system to facilitate favorable cell–material interactions and the supportive effect of neuroprotection.
  • 340
  • 14 Aug 2023
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