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Topic Review
Detection of Food Allergens
Food allergies have seriously affected the life quality of some people and even endangered their lives. At present, there is still no effective cure for food allergies. Avoiding the intake of allergenic food is still the most effective way to prevent allergic diseases. Therefore, it is necessary to develop rapid, accurate, sensitive, and reliable analysis methods to detect food allergens from different sources. Aptamers are oligonucleotide sequences that can bind to a variety of targets with high specifificity and selectivity, and they are often combined with different transduction technologies, thereby constructing various types of aptamer sensors. In recent years, with the development of technology and the application of new materials, the sensitivity, portability, and cost of flfluorescence sensing technology have been greatly improved. Therefore, aptamer-based flfluorescence sensing technology has been widely developed and applied in the specifific recognition of food allergens.
  • 639
  • 12 Nov 2021
Topic Review
An Easier Time Gaining Than Losing Weight
Three powerful innate physiological defenses interfere with the maintenance of weight loss, whether it is achieved from the obese or healthy weight level. The first one, called adaptive thermogenesis, consists of persistent reduction in resting metabolic rate (RMR), the second one is increased hunger, and the third one is enhanced efficiency of energy storage. Adaptive thermogenesis was studied in individuals who lost substantial amounts of body weight and body fat in attempts to win “The biggest loser” televised competition.
  • 589
  • 11 Nov 2021
Topic Review
Carnitine in Mitochondrial Fatty Acid Transport and β-Oxidation
l-Carnitine is an amino acid derivative widely known for its involvement in the transport of long-chain fatty acids into the mitochondrial matrix, where fatty acid oxidation occurs. Moreover, l-Carnitine protects the cell from acyl-CoA accretion through the generation of acylcarnitines.
  • 1.7K
  • 11 Nov 2021
Topic Review
Skeletal Fluorosis
Fluorine is widely dispersed in nature and has multiple physiological functions. Although it is usually regarded as an essential trace element for humans, this view is not held universally. Moreover, chronic fluorosis, mainly characterized by skeletal fluorosis, can be induced by long-term excessive fluoride consumption. High concentrations of fluoride in the environment and drinking water are major causes, and patients with skeletal fluorosis mainly present with symptoms of osteosclerosis, osteochondrosis, osteoporosis, and degenerative changes in joint cartilage. Etiologies for skeletal fluorosis have been established, but the specific pathogenesis is inconclusive. Currently, active osteogenesis and accelerated bone turnover are considered critical processes in the progression of skeletal fluorosis. In recent years, researchers have conducted extensive studies in fields of signaling pathways (Wnt/β-catenin, Notch, PI3K/Akt/mTOR, Hedgehog, parathyroid hone, and insulin signaling pathways), stress pathways (oxidative stress and endoplasmic reticulum stress pathways), epigenetics (DNA methylation and non-coding RNAs), and their inter-regulation involved in the pathogenesis of skeletal fluorosis.
  • 693
  • 11 Nov 2021
Topic Review
Hyperacusis in Autism Spectrum Disorders
Decreased Sound Tolerance Disorders (DSTD) are routinely observed in autism spectrum disorder (ASD). The most common types of DSTD are hyperacusis and misophonia. Hyperacusis is a class of decreased sound tolerance disorders in which a negative or incongruous reaction is triggered from exposure to sounds that are not described as threatening or uncomfortable by a neurotypical individual. These reactions are in response to general sounds, rather than specific sounds (such as chewing and sniffling), as would be the case with misophonia. Hyperacusis can affect an individual at various degrees depending on the severity. It can impact one’s emotional wellbeing, sleep, concentration, and can cause anxiety.
  • 1.1K
  • 11 Nov 2021
Topic Review
Natural Milk Microbiota
Profound bioactivities of raw breastmilk include benefits attributed to the dense and diverse natural microbiota, termed natural microbiota hereafter. Infants benefit from breastfeeding not just nutritionally, but by both ‘seeding and feeding’ the infant gut , providing microbes that seed the naïve gastrointestinal (GI or gut) ecosystem and nutritive components that feed both infant and microbial cells.
  • 601
  • 11 Nov 2021
Topic Review
Microbiological Food Safety of Seaweeds
The use of seaweeds in the human diet has a long history in Asia and has now been increasing also in the western world. Concurrent with this trend, there is a corresponding increase in cultivation and harvesting for commercial production. Edible seaweed is a heterogenous product category including species within the green, red, and brown macroalgae. Moreover, the species are utilized on their own or in combinatorial food products, eaten fresh or processed by a variety of technologies. 
  • 699
  • 11 Nov 2021
Topic Review
Human Milk Microbiota on Maternal and Child Health
Human milk (HM) is considered the most complete food for infants as its nutritional composition is specifically designed to meet infant nutritional requirements during early life. HM also provides numerous biologically active components, such as polyunsaturated fatty acids, milk fat globules, IgA, gangliosides or polyamines, among others; in addition, HM has a “bifidogenic effect”, a prebiotic effect, as a result of the low concentration of proteins and phosphates, as well as the presence of lactoferrin, lactose, nucleotides and oligosaccharides. Recently, has been a growing interest in HM as a potential source of probiotics and commensal bacteria to the infant gut, which might, in turn, influence both the gut colonization and maturation of infant immune system. Our review aims to address practical approaches to the detection of microbial communities in human breast milk samples, delving into their origin, composition and functions. Furthermore, we will summarize the current knowledge of how HM microbiota dysbiosis acts as a short- and long-term predictor of maternal and infant health. Finally, we also provide a critical view of the role of breast milk-related bacteria as a novel probiotic strategy in the prevention and treatment of maternal and offspring diseases.
  • 355
  • 11 Nov 2021
Topic Review
Preventing Physical Inactivity during Future Pandemics
Wearable activity trackers are devices that are comfortably worn on the body and are designed to be effective in monitoring daily physical activity and improving physical fitness of the wearer. This review aimed to investigate the impact of the coronavirus disease 2019 (COVID-19) pandemic on physical activity measured using wearable activity trackers and discuss future perspectives on wearable activity trackers during pandemics. Daily physical activity was significantly decreased during the COVID-19 pandemic.
  • 471
  • 10 Nov 2021
Topic Review
MPM Nodal Status: Where are We at?
Due to the lack of both prospective trial and high-volume retrospective studies, the management of clinical N+ malignant pleural mesothelioma (MPM) patients remain highly debated. Node positive patients show poor survival compared with node-negative ones; thus, lymph node staging appears crucial in determining treatment strategy. Notwithstanding the improvement in pre-treatment staging and the update on lymph node classification in the 8th edition of TNM, several open controversies remain on N parameter. How should people stage suspected N+ patients? How should people treat node positive patients?  Which is the definition of “resectable patient”?  Is the site or the number the main prognostic factor for node positive patients?  The aim of the entry is to analyse the existing relevant literature on lymph node status in MPM.
  • 441
  • 09 Nov 2021
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