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Topic Review
Organoselenium Compounds
Organoselenium compounds have anti-oxidative effects, several natural and synthetic organoselenium compounds and metabolites act as histone deacetylase inhibitors, which influence the acetylation status of histones and non-histone proteins, altering gene transcription.
  • 614
  • 14 Feb 2022
Topic Review
Telemedicine Applications in the Era of COVID-19
Telemedicine allows for the effective delivery of health care to patients at a distance through the application of information technology to the field of medicine. This is optimal during the COVID-19 pandemic to reduce interpersonal contact to mitigate contagion. 
  • 539
  • 14 Feb 2022
Topic Review
Non-alcoholic Fatty Liver Disease Pathogenesis and Oxidative Stress
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple factors, which may partly explain why it still remains an orphan of adequate therapies. It highlights the interaction between oxidative stress (OS) and disturbed lipid metabolism. Several reactive oxygen species generators, including those produced in the gastrointestinal tract, contribute to the lipotoxic hepatic (and extrahepatic) damage by fatty acids and a great variety of their biologically active metabolites in a “multiple parallel-hit model”. This leads to inflammation and fibrogenesis and contributes to NAFLD progression. The alterations of the oxidant/antioxidant balance affect also metabolism-related organelles, leading to lipid peroxidation, mitochondrial dysfunction, and endoplasmic reticulum stress. This OS-induced damage is at least partially counteracted by the physiological antioxidant response. Therefore, modulation of this defense system emerges as an interesting target to prevent NAFLD development and progression. For instance, probiotics, prebiotics, diet, and fecal microbiota transplantation represent new therapeutic approaches targeting the gut microbiota dysbiosis. The OS and its counter-regulation are under the influence of individual genetic and epigenetic factors as well.
  • 652
  • 14 Feb 2022
Topic Review
Rehabilitation of Motor Impairment in Stroke
Stroke is categorized as one of the most concerning global health issues as it is a serious and common disabling factor worldwide. Ageing and urbanization are two powerful drivers of stroke. The elderly population is at higher risk of experiencing a stroke, but stroke can be prevented to some extent by dealing with the modifiable menace factors such as physical inactivity, drugs, unhealthy diet, and tobacco so that problems such as hypertension, high blood pressure, and diabetes, which are the root causes of the epidemic, may be managed. Different therapies are described, such as functional electric stimulation (FES), noninvasive brain stimulation (NIBS) including transcranial direct current stimulation (t-DCS) and transcranial magnetic stimulation (t-MS), invasive epidural cortical stimulation, virtual reality (VR) rehabilitation, task-oriented therapy, robot-assisted training, tele rehabilitation, and cerebral plasticity for the rehabilitation of upper extremity motor impairment. New therapeutic rehabilitation techniques are also being investigated, such as VR. 
  • 327
  • 11 Feb 2022
Topic Review
Vitamin D Deficiency Status in Malaysia
Vitamin D is essential for maintaining serum calcium levels, ensuring sufficient bone mineralization, immunomodulatory properties, and a protective effect on the cardiovascular system, renal disease, cancer, as well as in pregnancy. Vitamin D deficiency can be managed with pharmacological or non-pharmacological approaches, depending on the severity. The objective is to raise serum vitamin D to a normal level, hence, relieving the symptoms and reducing the adverse health outcomes. Despite no clear guidelines in treating vitamin D deficiency in Malaysia, this condition can be prevented with taking adequate vitamin D in food resources, sun exposure, or supplementation. Special attention should be given to high-risk groups including infants, obese patients, and the elderly.
  • 649
  • 11 Feb 2022
Topic Review
Biliary Atresia
The term biliary atresia has substituted the original term of “extrahepatic biliary atresia”, which has been in use for several generations. The concept was related to the often-identified absence of gallbladder with an obliterated cord at the site the extrahepatic biliary system. It is now known that biliary atresia is a necro-inflammatory and fibro-obliterative process of both intrahepatic and extrahepatic biliary tract.
  • 653
  • 11 Feb 2022
Topic Review
Antioxidants in Hops
Hop plant (Humulus lupulus L.) has been used by humans for ages, presumably first as a herbal remedy, then in the manufacturing of different products, from which beer is the most largely consumed. Female hops cones have different useful chemical compounds, an important class being antioxidants, mainly polyphenols.
  • 645
  • 10 Feb 2022
Topic Review
Factors Influencing Usage Behavior on Mobile Health Applications
As people pay more attention to health, mobile health applications (mHealth apps) are becoming popular. These apps offer health services that run on mobile devices to help improve users’ health behaviors. However, few studies explore what motivates users to continue to use these apps. 
  • 769
  • 10 Feb 2022
Topic Review
Magnetic Fields and Cancer
Humans are exposed to a complex mix of man-made electric and magnetic fields (MFs) at many different frequencies, at home and at work. Epidemiological studies indicate that there is a positive relationship between residential/domestic and occupational exposure to extremely low frequency electromagnetic fields and some types of cancer.
  • 504
  • 10 Feb 2022
Topic Review
Nosocomial Infections and Role of Nanotechnology
Nosocomial infections, termed hospital-acquired infections (HAIs), are acquired from a healthcare or hospital setting. HAI is mainly caused by bacteria, such as Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Enterococci spp., Methicillin-resistant Staphylococcus aureus (MRSA), and many more. Due to growing antibacterial resistance, nanotechnology has paved the way for more potent and sensitive methods of detecting and treating bacterial infections.
  • 548
  • 09 Feb 2022
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