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Topic Review
Application of Sol–Gels for Treatment of Gynaecological Conditions
Approaches for effective and sustained drug delivery to the female reproductive tract (FRT) for treating a range of gynaecological conditions remain limited. The development of versatile delivery platforms, such as soluble gels (sol–gels) coupled with applicators/devices, holds considerable therapeutic potential for gynaecological conditions. Sol–gel systems, which undergo solution-to-gel transition, triggered by physiological conditions such as changes in temperature, pH, or ion composition, offer advantages of both solution- and gel-based drug formulations. Furthermore, they have potential to be used as a suitable drug delivery vehicle for other novel drug formulations, including micro- and nano-particulate systems, enabling the delivery of drug molecules of diverse physicochemical character. Hence, such systems are are of profound significance in delivering the drugs to various parts of FRT for optimal treatment of various gynecological conditions which was not achievable using conventional drug delivery technologies.
  • 979
  • 24 Feb 2022
Topic Review
Lung Nodule Segmentation
The accurate segmentation of lung nodules is challenging due to their small size, especially at the edge of the lung and near the blood vessels. Lung nodule segmentation is relatively broad and varies in terms of architecture, image pre-processing, and training strategy.
  • 585
  • 24 Feb 2022
Topic Review
Ionizing Radiation
The development of protective agents against harmful radiations has been a subject of investigation for decades. However, effective (ideal) radioprotectors and radiomitigators remain an unsolved problem. Because ionizing radiation-induced cellular damage is primarily attributed to free radicals, radical scavengers are promising as potential radioprotectors. Early development of such agents focused on thiol synthetic compounds, e.g., amifostine (2-(3-aminopropylamino) ethylsulfanylphosphonic acid), approved as a radioprotector by the Food and Drug Administration (FDA, USA) but for limited clinical indications and not for nonclinical uses. To date, no new chemical entity has been approved by the FDA as a radiation countermeasure for acute radiation syndrome (ARS). All FDA-approved radiation countermeasures (filgrastim, a recombinant DNA form of the naturally occurring granulocyte colony-stimulating factor, G-CSF; pegfilgrastim, a PEGylated form of the recombinant human G-CSF; sargramostim, a recombinant granulocyte macrophage colony-stimulating factor, GM-CSF) are classified as radiomitigators. No radioprotector that can be administered prior to exposure has been approved for ARS. This differentiates radioprotectors (reduce direct damage caused by radiation) and radiomitigators (minimize toxicity even after radiation has been delivered). Molecules under development with the aim of reaching clinical practice and other nonclinical applications are discussed. Assays to evaluate the biological effects of ionizing radiations are also analyzed. Ionizing radiation is the energy released by atoms in the form of electromagnetic waves (e.g., X or gamma rays) or particle radiation (alpha, beta, electrons, protons, neutrons, mesons, prions, and heavy ions) with sufficient energy to ionize atoms or molecules.
  • 2.1K
  • 23 Feb 2022
Topic Review
Forest Rescue Point System
Forest work is dangerous. In particular, manual or motor manual work still exists in large parts of both the professional sector and in the management of small private forests. For example, Germany has a large number of forest owners, estimated at approx. 2,000,000. Accidents that happen in the forest often involve severe injuries. In 2020, 4834 (2019: 5257) accidents during forestry work were reported in Germany. 1533 (2019: 1680) people were so seriously injured that they were unable to work for more than three days. 26 (2019: 36) people lost their lives while working in the forest. The system of fixed rescue points has been established in some areas of Germany for a long time. For example, a system of fixed rescue meeting points was established in the Bavarian state forest as early as the 1990s. In addition to establishing a clear meeting point for the rescue service, providing the fastest route to a landline telephone also played a major role at that time. With the current predominant use of smartphones, the role of the rescue meeting points has changed.
  • 920
  • 23 Feb 2022
Topic Review
Older Adults with Cancer and COVID-19
Older adults with cancer are amongst the most vulnerable population to be negatively impacted by COVID-19 due to their likelihood of comorbidities and compromised immune status. Considering the longevity of the pandemic, understanding the subjective perceptions and psychosocial concerns of this population may help ameliorate the psychological aftermath.
  • 569
  • 23 Feb 2022
Topic Review
Oxygen Consumption (VO2) and Surface Electromyography (sEMG)
Oxygen consumption (VO2) during strength training can be predicted through surface electromyography (sEMG) of local muscles. Surface electromyography (EMG; sEMG), one of the most common methods of measuring muscle activation, is an electrophysiological recording technique for detecting the electric potential across muscle fiber membranes.
  • 488
  • 22 Feb 2022
Topic Review
Dr. Dipankar Chakraborti: A Legend of Arsenic Research
This encyclopedia provides a brief biography of a legendary scientist Dr. Dipankar Chakraborti. Dr. Chakraborti pioneered arsenic research in the Ganga Meghna Brahmaputra Basin and dedicated his entire life to researching and serving arsenic-affected communities in India and Bangladesh. 
  • 2.1K
  • 22 Feb 2022
Topic Review
Fresh Produce with Antibiotic-Resistant Bacteria
Fresh produce, when consumed raw, can be a source of exposure to antimicrobial residues, antimicrobial-resistant bacteria (ARB) and antimicrobial resistance genes (ARGs) of clinical importance. The most commonly observed ARB were E. coli (42.5%) followed by Klebsiella spp. (22.5%), and Salmonella spp. (20%), mainly detected on lettuce.
  • 1.0K
  • 22 Feb 2022
Topic Review
Physical Activity among Children with Intellectual Disabilities
Children and adolescents with intellectual disabilities (ID) have low levels of physical activity (PA). Understanding factors influencing the PA participation of this population is essential to the design of effective interventions. Continued exploration of factors influencing PA participation is required among children and adolescents with ID. Future interventions should involve families, schools, and wider support network in promoting their PA participation together. 
  • 1.3K
  • 22 Feb 2022
Topic Review
Effects of Exercise on the Autonomic Nervous System
The autonomic nervous system (ANS) has an important impact on health in general. In response to environmental demands, homeostatic processes are often compromised, therefore determining an increase in the sympathetic nervous system (SNS)’s functions and a decrease in the parasympathetic nervous system (PNS)’s functions.
  • 3.9K
  • 21 Feb 2022
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