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Topic Review
Three-Dimensional Approaches in Complex Congenital Heart Disease
Echocardiography, CT and MRI have a crucial role in the management of congenital heart disease (CHD) patients. All of these modalities can be presented in a two-dimensional (2D) or a three-dimensional (3D) rendered format. 
  • 444
  • 07 Sep 2022
Topic Review
Carbon Footprints of Active and Non-Active Transport Modes
Carbon footprint is defined as the exclusive total amount of carbon dioxide emissions that are directly or indirectly caused by an activity or accumulated over the lifespan of a product. This definition suggests that a carbon footprint can be generated directly or indirectly by an individual through daily behaviours. 
  • 443
  • 14 Nov 2023
Topic Review
The Role of Insulin-like Growth Factor-1
The anterior pituitary also referred to as the adenohypophysis, originates from the oral ectoderm during embryonic development. It is enclosed by a network of blood capillaries originating from the hypothalamus, as a part of the hypophyseal portal system, responsible for transporting hormones from the hypothalamus to the anterior pituitary and from the anterior pituitary to the circulatory system. Hence, the hypophyseal portal system prevents hypothalamic hormones from entering directly into the circulation..
  • 443
  • 29 Mar 2022
Topic Review
Detection of SARS-CoV-2 through Wastewater
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was detected in Wuhan, China. The clinical manifestation of COVID-19 varies from asymptomatic to severe infection.
  • 443
  • 07 Dec 2021
Topic Review
AI and Neural Network Algorithms
Al increases the potential of Micro-Electro-Mechanical System biosensors and opens up new opportunities for automation, consumer electronics, industrial manufacturing, defense, medical equipment, etc. Micro-Electro-Mechanical System microcantilever biosensors are currently making their way into the daily lives and playing a significant role in the advancement of social technology. Micro-Electro-Mechanical System biosensors with microcantilever structures have a num- ber of benefits over conventional biosensors, including small size, high sensitivity, mass production, simple arraying, integration, etc. These advantages have made them one of the development avenues for high-sensitivity sensors. The next generation of sensors will exhibit an intelligent development trajectory and aid people in interacting with other objects in a variety of scenario applications as a result of the active development of artificial intelligence (AI) and neural networks. A neural algorithm application in Micro-Electro-Mechanical System microcantilever biosensors is anticipated through the associated application of the principal com-ponent analysis approach. Researchers investigation has more scientific study value, because there are currently no favorable reports on the market regarding the use of AI with Micro-Electro-Mechanical System microcantilever sensors.
  • 443
  • 13 Sep 2022
Topic Review
Stress of Moving Homes
Moving homes has long been considered stressful, but how stressful is it? Researches try to utilise a micro-level individual dataset in the New Zealand Government’s Integrated Data Infrastructure (IDI) to reconstruct the Social Readjustment Rating Scale (SRRS) and thereby measure stress at a whole-of-population level. The effects of residential mobility on people’s mental well-being in the context of their stress-of-moving homes are examined.
  • 443
  • 21 Nov 2022
Topic Review
Environmental Pollution and the Risk of Metabolic Disorders
Metabolic disorders are a spectrum of diseases that affect normal metabolic functioning and regulation. More than 500 metabolic disorders exist, two of the most common being diabetes mellitus and obesity. Obesity is a multifactorial disorder involving the interaction of genetics, lifestyle and environment. It results in excessive adipose tissue deposition and is defined by a body mass index (BMI) greater than 30 kg/m2. In addition, obesity is the leading cause of metabolic syndrome and insulin resistance. Type 2 diabetes is characterized by an elevated blood glucose level, a chronic hyperglycemic state caused by a combination of pancreatic β-cell loss through apoptosis and insulin resistance in peripheral tissues, such as skeletal muscle. By contrast, type 1 diabetes is caused by autoimmune attack upon pancreatic β-cells, causing an almost complete loss of insulin production and secretion. Whilst a genetic predisposition can underlie the onset of type 1 diabetes, with particular loci of interest having been identified, environmental factors may also contribute. Well-established risk factors for type 2 diabetes and obesity are a sedentary lifestyle, poor nutrition, insulin resistance, environmental factors and genetics.
  • 442
  • 08 Jun 2023
Topic Review
Therapeutic Response-Related Ferroptosis Regulators in Bladder Cancer
Ferroptosis, an iron-dependent form of regulated cell death characterized by the accumulation of lipid peroxidation, has been reported to regulate tumorigenesis, metastasis, drug resistance and the immune response. However, the potential roles of ferroptosis regulators in the progression of bladder cancer (BLCA) remain unknown. We systematically evaluated the multidimensional alteration landscape of ferroptosis regulators in BLCA and checked if their expression correlated with the ferroptosis index. Using least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox regression, a seven ferroptosis regulator signature was constructed. We validated the prognostic and predictive accuracy of this signature in five independent datasets and established a nomogram to predict the overall survival (OS) and risk of death of BLCA patients. Moreover, the risk score was associated with tumor progression and antitumor immunity-related pathways. Furthermore, the relative antitumor immune cell infiltration level was negatively correlated with the risk score, and the tumor mutation burden was higher in the low-risk group, which might be useful for predicting immunotherapy efficacy. The Tumor Immune Dysfunction and Exclusion (TIDE) database and IMvigor210 cohort with immunotherapy efficacy results were used to confirm the prediction function of the risk score. Furthermore, the ferroptosis regulator signature could also reflect the chemotherapy sensitivity of BLCA. Ferroptosis might play a role in precision individualized chemotherapy and immunotherapy. This entry highlights the crucial clinical implications of ferroptosis and will help with developing personalized therapeutic strategies for BLCA patients
  • 442
  • 13 Dec 2021
Topic Review
SARS-CoV-2 Mutational Pattern in Greece
From the 2500 clinical specimens, 220 were tested positive for SARS-CoV-2 indicating a prevalence of 8.8% among suspected cases. The RT-PCR Ct (Cycle threshold) Value ranged from 19 to 25 which corresponds to medium to high copy numbers of the virus in the positive samples.
  • 442
  • 21 Jan 2022
Topic Review
Risk Factors of Sleep Apnea
Obstructive sleep apnea (OSA), a condition in which there is a recurrent collapse of the upper airway while sleeping, is a widespread disease affecting 5% to 10% people worldwide. Despite several advances in the treatment modalities for OSA, morbidity and mortality remain a concern. Common symptoms include loud snoring, gasping for air during sleep, morning headache, insomnia, hypersomnia, attention deficits, and irritability. Obese individuals, male gender, older age (65+), family history, smoking, and alcohol consumption are well recognized risk factors of OSA.
  • 442
  • 09 Feb 2023
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