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Biography
Vulstan James Shedura
Vulstan James Shedura is a Field Epidemiologist holding a Master’s degree in Epidemiology and Laboratory Management at the Muhimbili University of Health and Allied Sciences (MUHAS), and  a Medical Laboratory Scientist holding a Bachelor’s degree from International Medical and Technological University (IMTU). He studied a total of three online diplomas in Leadership and Management, Water Sa
  • 1.0K
  • 30 Nov 2023
Topic Review
Vitamin D on Skin Aging
The normal vitamin D3 status is important for a general prevention of premature aging maintaining a healthful skin aging. Vitamin D3metabolites including its classical (1,25(OH)2D3) and novel (CYP11A1-intitated) D3hydroxyderivatives exert many beneficial protective effects on the skin, which could influence the process of premature aging via many different mechanisms, leading to a delay or attenuation of both chronological skin aging and photoaging. Skin-resident cells (keratinocytes, fibroblasts, and sebocytes) are capable of locally activating vitamin D3and exhibiting a diverse biological effect such as photoprotection and immunosuppression, similar to the UVR-induced one.
  • 620
  • 29 Sep 2021
Topic Review
Vitamin D Deficiency Status in Malaysia
Vitamin D is essential for maintaining serum calcium levels, ensuring sufficient bone mineralization, immunomodulatory properties, and a protective effect on the cardiovascular system, renal disease, cancer, as well as in pregnancy. Vitamin D deficiency can be managed with pharmacological or non-pharmacological approaches, depending on the severity. The objective is to raise serum vitamin D to a normal level, hence, relieving the symptoms and reducing the adverse health outcomes. Despite no clear guidelines in treating vitamin D deficiency in Malaysia, this condition can be prevented with taking adequate vitamin D in food resources, sun exposure, or supplementation. Special attention should be given to high-risk groups including infants, obese patients, and the elderly.
  • 552
  • 11 Feb 2022
Topic Review
Vitamin D and Preeclampsia
Preeclampsia (PE) is a set of clinical symptoms that appears after the 20th week of pregnancy. It is a multi-organ disease characterized by hypertension and proteinuria, and in the absence of proteinuria—an impairment of the functions of the internal organs. With regard to the multiple mechanisms of action of Vit D, its deficiency seems to be one of the possible factors conducive to PE development. It has been suggested that the consequence of low Vit D levels may be the appearance of an early, severe form of PE, and its supplementation may be a protective factor against its recurrence in subsequent pregnancies [232]. The relationship between Vit D and PE development may explain its impact on implantation, angiogenesis, and endothelial status, regulation of the immune response, effect on RAAS, and calcium metabolism. 
  • 517
  • 17 Nov 2021
Topic Review
Vitamin D and Iron on Skeletal Muscle Health
Many nutrients are essential for skeletal muscle health including vitamin D and iron. These nutrients have been well-established to play a role in improving muscular strength, muscle mass, and muscle function in various populations such as youth, athletes, and older adults. Together, muscular strength, muscle mass, and muscle function are important components that make up “skeletal muscle health”. Beyond the role that these nutrients have on skeletal muscle health, emerging literature has reported a link between vitamin D action on pro-inflammatory cytokines and mechanisms behind iron regulation, which may physiologically play a role in skeletal muscle health.
  • 388
  • 12 Jul 2022
Topic Review
Vitamin A and Pregnancy
Vitamin A is a crucial micronutrient for pregnant women and their fetuses. In addition to being essential for morphological and functional development and for ocular integrity, vitamin A exerts systemic effects on several fetal organs and on the fetal skeleton. 
  • 728
  • 09 Aug 2022
Topic Review
Visually Impaired Persons’ Assistance
The development of new solutions to assist blind people is a major research domain having great potential to enhance the daily lives of such people. These innovative solutions aim to augment the perception of the surrounding environment for the blind and severely visually impaired. 
  • 133
  • 06 Dec 2023
Topic Review
VISTA, PDL-L1, and BRAF—Markers in Prognosis of Melanoma
Melanoma is currently known as one of the most aggressive malignant tumors. T cell Activation (VISTA) is a novel target that is considered to be highly important in determining the invasive potential and treatment response of a melanoma. Programmed death-ligand 1 (PD-L1) is a marker with whose importance has been revealed in multiple types of malignancies.
  • 393
  • 29 Mar 2022
Topic Review
Virtual Reality and Its Influence on Brain Health
Dynamic technological development and its enormous impact on modern societies are posing new challenges for 21st-century neuroscience. A special place is occupied by technologies based on virtual reality (VR). VR tools have already played a significant role in both basic and clinical neuroscience due to their high accuracy, sensitivity and specificity and, above all, high ecological value. Being in a digital world affects the functioning of the body as a whole and its individual systems. The data obtained so far, both from experimental and modeling studies, as well as (clinical) observations, indicate their great and promising potential, but apart from the benefits, there are also losses and negative consequences for users.
  • 75
  • 01 Feb 2024
Topic Review
Virtual Care
Virtual care extends beyond the walls of healthcare organizations to provide care at a distance. Virtual care encompasses the provision of care using advanced video conferencing technology to support remote care that takes place between patients and providers and the use of virtual reality technology to simulate care environments. Some of virtual care’s use in healthcare includes application to pain and anxiety management, virtual consultations and follow-up visits, rehabilitation and therapy services, outpatient clinics, and emergency services.
  • 378
  • 23 Nov 2021
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