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Topic Review
Upfront Chemotherapy Followed by SBRT in Pancreatic Cancer
Multimodality therapy involving stereotactic body radiation therapy (SBRT) is safe and feasible in older patients with localized pancreatic cancer. Surgical resection was associated with improved clinical outcomes. As such, older patients who complete chemotherapy should not be excluded from aggressive local therapy when possible.
  • 288
  • 14 Jan 2022
Topic Review
Ultrasound-Guided Ethanol Ablation for Thyroglossal Duct Cyst
The thyroglossal duct cyst (TGDC) is the most common congenital neck mass, accounting for 70–75% of all congenital neck masses. Although the Sistrunk operation has been used as a standard of treatment, it is accompanied by a considerable surgical burden, including the need for general anesthesia, a visible surgical scar on the neck surface, and postoperative complications. Ultrasound-guided ethanol ablation (US-EA) is a minimally invasive and office-based technique that is widely used as a non-surgical treatment for several benign cystic lesions, particularly benign thyroid cysts. US-EA has also been gaining popularity as a good alternative for TGDC treatment, which is associated with high feasibility, a high safety profile, and favorable treatment outcomes. 
  • 194
  • 26 Oct 2023
Topic Review
Ultrasound in Telemedicine
The term telemedicine was to describe the practice of delivering health care services through the use of information and communications technology, whereby geographic distance is not as constraining, as in the case of traditional medical practice. Telemedicine is not only used to exchange valid information for the diagnosis, treatment, and prevention of disease and injuries and research and evaluation, but also for the continuing the education of healthcare providers to advance individual and community health.
  • 473
  • 10 Feb 2022
Topic Review
Ultrasound in Imaging Diagnosis of Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) accounts for a great majority of liver cancer diagnoses and deaths. Imaging plays, therefore, a crucial role in the surveillance of patients at risk, the detection and diagnosis of HCC nodules, as well as in the follow-up post-treatment. The unique imaging characteristics of HCC lesions, deriving mainly from the assessment of their vascularity on contrast-enhanced computed tomography (CT), magnetic resonance (MR) or contrast-enhanced ultrasound (CEUS), allow for a more accurate, noninvasive diagnosis and staging.
  • 370
  • 21 Feb 2023
Topic Review
Two Analytical Approaches of Quantitative Imaging
As the most lethal major cancer, pancreatic cancer is a global healthcare challenge. Personalized medicine utilizing cutting-edge multi-omics data holds potential for major breakthroughs in tackling this critical problem. Radiomics and deep learning, two trendy quantitative imaging methods that take advantage of data science and modern medical imaging, have shown increasing promise in advancing the precision management of pancreatic cancer via diagnosing of precursor diseases, early detection, accurate diagnosis, and treatment personalization and optimization. Radiomics employs manually-crafted features, while deep learning applies computer-generated automatic features. These two methods aim to mine hidden information in medical images that is missed by conventional radiology and gain insights by systematically comparing the quantitative image information across different patients in order to characterize unique imaging phenotypes. Both methods have been studied and applied in various pancreatic cancer clinical applications. 
  • 345
  • 13 Apr 2022
Topic Review
Treatment of Pancreatic Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) accounts for the majority of pancreatic cancers and is associated with poor prognosis, a high mortality rate, and a substantial number of healthy life years lost. Surgical resection is the primary treatment option for patients with resectable disease; however, only 10–20% of all patients with PDAC are eligible for resection at the time of diagnosis.
  • 168
  • 01 Dec 2023
Topic Review
Transarterial Chemoembolization for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. It is principally associated with liver cirrhosis and chronic liver disease. The major risk factors for the development of HCC include viral infections (HBV, HCV), alcoholic liver disease (ALD,) and non-alcoholic fatty liver disease (NAFLD). The optimal treatment choice is dictated by multiple variables such as tumor burden, liver function, and patient’s health status. Surgical resection, transplantation, ablation, transarterial chemoembolization (TACE), and systemic therapy are potentially useful treatment strategies. TACE is considered the first-line treatment for patients with intermediate stage HCC. 
  • 751
  • 24 Mar 2022
Topic Review
Tissue Section-Based Immune Profiling
Technologies based on tissue sections are amongst the most common tools used for both morphologic and molecular characterization of cancers. These tools provide several unique advantages, most notably the preservation of spatial information. Furthermore, many of these assays can be performed on archival tissue, allowing for the post hoc analysis of preserved paraffin embedded samples in tissue banks. 
  • 420
  • 03 Aug 2022
Topic Review
Theranostic Radiopharmaceuticals
Theranostic Radiopharmaceuticals (Radiotheranostics) is a term in the medical field to define the combination of therapeutic and diagnostic techniques by a suitable radiopharmaceutical agent. Radionuclides are isotopes that emit radiation or have excess nuclear energy, making them chemically unstable and tend to change into another atom. Various types of radiation can be emitted by radionuclides e.g. alpha particles, beta particles, and gamma energy. In radiotheranostics, a pharmaceutical agent (drug) is needed to be a carrier molecule that introduces the radionuclide to its target. Radionuclides are then used as a source of radiation in radiotheranostics that are responsible for diagnosing or treating various diseases.
  • 1.3K
  • 24 May 2022
Topic Review
Theranostic Imaging Surrogates for Targeted Alpha Therapy
Most targeted alpha therapy (TAT) radionuclides lack or possess insufficient co-emitted positrons or gamma rays for acquiring higher-quality positron emission tomography (PET) or single-photon emission computed tomography (SPECT) scans. This motivated the development of chemically similar diagnostic imaging surrogates for TAT radionuclides. As the current supply of alpha-emitting radionuclides is scarce, utilizing imaging surrogates also has the potential to open more opportunities for TAT research to facilities without access to alpha-emitting radionuclides and serve as a bridge for centers planning to introduce TAT radiopharmaceuticals. Since many of these surrogates can be synthesized in existing cyclotron facilities, this can facilitate radiopharmaceutical developments.
  • 114
  • 27 Nov 2023
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