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Topic Review
Vaccinology in the COVID-19 Pandemic Era
Different approaches have been used in parallel to make COVID-19 vaccines, including the use of nucleic acid-based vectors, whole virus (live-attenuated and inactivated), viral vectors (replicating and nonreplicating), adjuvant recombinant protein nanoparticles, and virus-like particles (VLPs). Among the protective antigens of SARS-CoV-2, the attention has mainly focused on the native S protein, which is able to induce potent neutralizing antibodies, even if its presentation to the immune system differs substantially between the different categories of vaccines. However, new evidence is being raised about potential roles for other, more conserved non-spike viral antigens, such as nucleocapsid (N) proteins, which might represent an innovation in the fight against emerging SARS-CoV-2 variants and a source for universal vaccines providing long-lasting immunity.
  • 470
  • 29 Apr 2022
Topic Review
Vaccines for Human Papillomavirus-Associated Head and Neck Cancers
Human papillomavirus (HPV) is recognized as a significant risk factor for head and neck cancers worldwide, and it is the most common cause of oropharyngeal cancers in the United States. Prophylactic HPV vaccines have demonstrated effectiveness against oral infection of HPV 16 and HPV 18. There are also various strategies in development of therapeutic HPV vaccines underway.
  • 377
  • 10 Jan 2022
Topic Review
Vaccines for Bovine Mycoplasmoses
Two of the most important diseases of cattle are caused by mycoplasmas. Mycoplasma bovis is a world-wide bovine pathogen that can cause pneumonia, mastitis and arthritis. Due to its increasing resistance to antimicrobial therapy, vaccination is the principal focus of the control of infection, but effective vaccines are currently lacking. Despite being eradicated from most parts of the world, Mycoplasma mycoides subsp. mycoides, the cause of contagious bovine pleuropneumonia (CBPP), continues to plague sub-Saharan Africa. Numerous new experimental vaccines have been developed over the last 20 years to improve on protection afforded by the T1/44, a live vaccine in continuous use in Africa for over 60 years, but none so far have succeeded; indeed, many have exacerbated the disease.
  • 559
  • 23 Jun 2021
Topic Review
Vaccines against Antibiotic Resistance
Despite the great efforts made by researchers and companies to develop new antimicrobial drugs, only a few molecules have been recognized so far as effective antibiotic candidates. In fact, the number of new antimicrobials developed later than the 90s has progressively diminished, and many of them correspond to slight modifications of existing drugs. Apart from the difficulties in developing new effective antimicrobials, the worrying scenario of the antimicrobial resistance (AMR) recalls the urgent need of new strategies to fight the bacterial infections. Among the others, vaccination is a winning solution to the problem of the  AMR, at least in the context of some of the most common pathogenic bacteria.
  • 441
  • 14 Feb 2023
Topic Review
Vaccine Hesitancy
Vaccination, despite being recognized as one of the most effective primary public health measures, is viewed as unsafe and unnecessary by an increasing number of individuals. Vaccination is one of the most significant public health achievements, having contributed to the eradication of smallpox and the control of many infectious diseases such as rubella, diphtheria, and polio globally.
  • 567
  • 20 Oct 2022
Topic Review
Vaccinations of COVID-19
Vaccination has been identified as a critical method of disease control in the context of the current COVID-19 pandemic. This research updated information on vaccine development and to identify areas of concern that require further research. The researchers reviewed the literature on the development of COVID-19 vaccines, their efficacy, and use in special populations, as well as current vaccination strategies. To date, 170 vaccines are in clinical development, with 41 being already approved for use in various countries. The majority of vaccines approved for human use are vector-, subunit-, DNA-, or mRNA-based vaccines, or inactivated viruses. Because of the ongoing mutation of the SARS-CoV-2 virus, well-studied vector vaccines are losing relevance due to the ability of new virus strains to bypass neutralizing antibodies. Simultaneously, PS-based vaccines are becoming more popular. There is mounting evidence that the immunogenicity of COVID-19 vaccines is linked to their clinical efficacy. This has resulted in a shift in vaccination strategies, as well as the use of booster doses and revaccination. Furthermore, vaccination restrictions for children, pregnant women, the elderly, and people with chronic immunosuppressive diseases have been lifted, allowing more people to be vaccinated. New data on vaccine safety, including the incidence of serious adverse events, have been collected. Despite significant advances in the development of and research on COVID-19 vaccines, many questions remain that require further investigation.
  • 388
  • 06 Dec 2022
Topic Review
Vaccinations and Autoimmune Diseases
Vaccines represent one of the most effective measures of public health medicine, saving countless lives and preventing lifelong disabilities. Among the adverse reactions to vaccines, one of the most feared is the triggering of autoimmune diseases, which are a heterogeneous group of disorders characterized by dysregulation of the immune system. Currently, no mechanisms have been demonstrated that could explain the correlation between vaccination and the development of autoimmune diseases. Furthermore, epidemiological studies do not support the hypothesis that vaccines cause systemic autoimmune diseases. The only confirmed associations, although very rare, are those between the flu vaccine and Guillain-Barré syndrome, especially with old vaccine preparations, and measles-mumps-rubella (MMR) vaccine and thrombocytopenia. 
  • 816
  • 24 Nov 2021
Topic Review
Vaccination Recommendations for Patients with Systemic Sclerosis
Systemic sclerosis (SSc) is a rare autoimmune inflammatory rheumatic disease. Vaccines represent one of the safest and most effective means of disease control. 
  • 643
  • 14 Dec 2021
Topic Review
Use of COVID-19 Boosters among Health Care Providers
While the World Health Organization (WHO) has de-escalated coronavirus disease 2019 (COVID-19) from a global health emergency, ongoing discussions persist as new viral variants. 
  • 141
  • 27 Feb 2024
Topic Review
Urinary Tract Infections during the COVID-19 Pandemic
The landscape of management of urinary tract infections (UTI) is changing rapidly. The COVID-19 pandemic draws the attention to the SARS-CoV-2 management with a subsequent reduced attention on bacterial infections. The COVID-19 diffusion containing procedures, such as use of facemasks and handwashing, have reduced spreading of bacteria and bacterial lung infections.
  • 2.5K
  • 21 Mar 2022
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