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Topic Review
Glucocorticoid-Induced Osteoporosis (GIOP)
In a physiological state, glucocorticoids stimulate mature osteoblasts to produce Wnt proteins functioning as signaling molecules, causing a Wnt/β-catenin cascade to be activated. This signaling cascade affects mesenchymal progenitor cells, and has a positive effect on their differentiation into osteoblasts instead of chondrocytes or adipocytes. Glucocorticoids are the most widely used anti-inflammatory drug around the world. Despite their excellent effect in managing many acute inflammatory diseases and autoimmune disorders, the usage of glucocorticoids has been limited due to substantial adverse effects. One of the most well-known side effects is osteoporosis, which further induces bone fracture and other musculoskeletal problems.
  • 417
  • 18 Sep 2023
Topic Review
The Role of Biomarkers in Adrenocortical Carcinoma
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy arising from the adrenal cortex often with unexpected biological behavior. It can occur at any age, with two peaks of incidence: in the first and between fifth and seventh decades of life. Although ACC are mostly hormonally active, precursors and metabolites, rather than end products of steroidogenesis are produced by dedifferentiated and immature malignant cells.
  • 416
  • 16 Feb 2023
Topic Review
Acute Hepatic Porphyrias
Porphyrias are a group of congenital and acquired diseases caused by an enzymatic impairment in the biosynthesis of heme. Depending on the specific enzyme involved, different types of porphyrias (i.e., chronic vs. acute, cutaneous vs. neurovisceral, hepatic vs. erythropoietic) are described, with different clinical presentations. Acute hepatic porphyrias (AHPs) are characterized by life-threatening acute neuro-visceral crises (acute porphyric attacks, APAs), featuring a wide range of neuropathic (central, peripheral, autonomic) manifestations.
  • 415
  • 19 Jan 2022
Topic Review
COVID-19 and Postural Control
Subjects who had experienced olfactory dysfunction or respiratory distress during COVID-19 demonstrate symptoms of balance deficits after COVID-19 recovery, and the analysis using rambling-trembling decomposition method might point at less efficient peripheral control. Monitoring for neurological sequelae of COVID-19 should be considered. 
  • 412
  • 21 Feb 2022
Topic Review
Gallbladder Cancer Therapy
Gallbladder cancer (GBC) is the most common form of biliary tract cancer. It is characterized by unique pathogenetic and molecular features that differ from other biliary tract cancer forms (e.g., inflammation-based carcinogenesis and distinctive molecular alterations, strong association with female sex, and geographical clustering). Therefore, differentiated therapy is mandatory to improve patients’ outcome and survival, especially regarding characteristic molecular alterations that bare the opportunity for the use of new targeted therapeutics.
  • 412
  • 30 Nov 2022
Topic Review
Thiogenistein's Anti-Cancer and Electrochemical Properties
Pharmacological and nutraceutical effects of isoflavones are attributed to their antioxidant activity protecting cells against carcinogenesis. The knowledge of the oxidation mechanisms of an active substance is crucial to determine its pharmacological properties.
  • 411
  • 11 Oct 2021
Topic Review
Skeletal Effects of Tanshinones
Osteoporosis results from excessive bone resorption and reduced bone formation, triggered by sex hormone deficiency, oxidative stress and inflammation. Tanshinones are a class of lipophilic phenanthrene compounds found in the roots of Salvia miltiorrhiza with antioxidant and anti-inflammatory activities, which contribute to its anti-osteoporosis effects. 
  • 410
  • 25 Apr 2021
Topic Review
Sleep Disorders and Diabetic Foot
Diabetic foot is associated with a low quality of life since physical disabilities, mood disturbances and psychological disorders are frequent. One of the most important biological processes to ensure quality of life is sleep. Sleep disorders can impair glycemic control in patients with diabetes mellitus or even cause long-term type 2 diabetes mellitus. 
  • 410
  • 05 Jul 2021
Topic Review
Molecular Mechanisms and Clinical Insights of Diabetic Vasculopathy
Clinical and basic studies have documented that both hyperglycemia and insulin-resistance/hyperinsulinemia not only constitute metabolic disorders contributing to cardiometabolic syndrome, but also predispose to diabetic vasculopathy, which refers to diabetes-mellitus-induced microvascular and macrovascular complications, including retinopathy, neuropathy, atherosclerosis, coronary artery disease, hypertension, and peripheral artery disease.
  • 410
  • 22 Jan 2024
Topic Review
Collagen Treatment
Collagen, the most abundant protein in our bodies, plays a crucial role in maintaining the structural integrity of various tissues and organs. Collagen treatment offers a range of advantages, including antioxidant and anti-inflammatory properties, wound healing support, benefits for hair and nail health, improvement in gut health, support for joint health, skin rejuvenation, and potential support for musculoskeletal disorders and cardiovascular health.
  • 407
  • 11 Oct 2023
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