Topic Review
Clean Language
Clean Language is a technique primarily used in counseling, psychotherapy and coaching but now also used in education, business, organisational change and health. More recently it has been applied as a research interview technique. Clean Language intends to support clients discovering and developing their own symbols and metaphors, rather than the therapist/coach/interviewer suggesting-contributing their own framing of a topic. In other words, instead of "supporting" the client by offering them ready-made metaphors, when the counselor senses a metaphor would be useful; or, is conspicuous by its absence, the counselor asks the client, "And that's like what?" The client is invited to innovate their own metaphor. The benefit to the counselor is the client is likely to come up with a metaphor from their most-open sensory channel. Learning a client's most open sensory channel is valuable for the counselor for future metaphor construction if the client is stuck. Clean Language was devised by David Grove in the 1980s as a result of his work on clinical methods for resolving clients' traumatic memories. Cei Davies Linn was closely involved in the early evolution and development of Grove's work such as Clean Language and Epistemological Metaphors. As Lawley and Tompkins describe it, Grove realized many clients were describing their symptoms in metaphors drawn from the words of previous therapists, instead of from their own experience. Clean Language also is the basis of Symbolic Modelling, a stand-alone method and process for psychotherapy and coaching, developed by Lawley and Tompkins; Clean Space; and Systemic Modelling, applied in organisational development. Clean Language can also be used in addition to a therapist or coach's existing approach.
  • 396
  • 26 Oct 2022
Topic Review
Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases
Pulmonary hypertension (PH) is a severe vascular complication of connective tissue diseases (CTD). Patients with CTD may develop PH belonging to diverse groups: (1) pulmonary arterial hypertension (PAH), (2) PH due to left heart disease, (3) secondary PH due to lung disease and/or hypoxia and (4) chronic thromboembolic pulmonary hypertension (CTEPH). PAH most often develops in systemic scleroderma (SSc), mostly in its limited variant. PAH-CTD is a progressive disease characterized by poor prognosis. Therefore, early diagnosis should be established.
  • 397
  • 13 Oct 2023
Topic Review
Inflammation and Hemorrhage/Coagulation in Primary Blast Lung Injury
Primary blast lung injury (PBLI), caused by exposure to high-intensity pressure waves from explosions in war, terrorist attacks, industrial production, and life explosions, is associated with pulmonary parenchymal tissue injury and severe ventilation insufficiency. PBLI patients, characterized by diffused intra-alveolar destruction, including hemorrhage and inflammation, might deteriorate into acute respiratory distress syndrome (ARDS) with high mortality. 
  • 396
  • 17 Feb 2023
Topic Review
Neuromyelitis Optica Spectrum Disorder
The term neuromyelitis optica was introduced by Eugène Devic and Fernand Gault in 1894, who first recognized the association of amaurosis and myelitis as a new clinical entity.
  • 394
  • 01 Sep 2021
Topic Review
Acute Hepatic Porphyrias
Porphyrias are a group of congenital and acquired diseases caused by an enzymatic impairment in the biosynthesis of heme. Depending on the specific enzyme involved, different types of porphyrias (i.e., chronic vs. acute, cutaneous vs. neurovisceral, hepatic vs. erythropoietic) are described, with different clinical presentations. Acute hepatic porphyrias (AHPs) are characterized by life-threatening acute neuro-visceral crises (acute porphyric attacks, APAs), featuring a wide range of neuropathic (central, peripheral, autonomic) manifestations.
  • 394
  • 19 Jan 2022
Topic Review
Thrombotic Disorders and COVID-19 Vaccines
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has affected hundreds of millions worldwide, leading to nearly 7 million deaths globally, although now declared not a worldwide concern anymore. Strenuous research and analysis of various vaccine advances led to the development of multiple COVID-19 vaccines in less than a year from the pandemic’s beginning. Different types of vaccines, such as mRNA vaccines, DNA vaccines, viral vector vaccines, and inactivated virus vaccines have been approved and have shown a high degree of efficacy with variable protective levels of up to 95% (70–95% range) in vaccinated individuals against COVID-19.
  • 393
  • 01 Nov 2023
Topic Review
Skeletal Effects of Tanshinones
Osteoporosis results from excessive bone resorption and reduced bone formation, triggered by sex hormone deficiency, oxidative stress and inflammation. Tanshinones are a class of lipophilic phenanthrene compounds found in the roots of Salvia miltiorrhiza with antioxidant and anti-inflammatory activities, which contribute to its anti-osteoporosis effects. 
  • 392
  • 25 Apr 2021
Topic Review
Epidemiology and Genetics of Mitochondrial Myopathies
Mitochondrial myopathies represent a heterogeneous group of diseases caused mainly by genetic mutations to proteins that are related to mitochondrial oxidative metabolism. The International Workshop of Experts in Mitochondrial Diseases defined mitochondrial myopathies as a group of progressive muscle conditions, primarily caused by the impairment of oxidative phosphorylation (OXPHOS).
  • 392
  • 11 Jan 2023
Topic Review
Diabetic Neuropathy
Diabetic neuropathy is defined as the dysfunction of the peripheral nervous system in diabetic patients. It is considered a microvascular complication of diabetes mellitus. Its presence is associated with increased morbidity and mortality. Although several studies have found alterations at somatic motor, sensory levels and at the level of autonomic nervous system in diabetic patients, there is not a systematic approach regarding the differences in neuropathy between the major variants of diabetes, e.g., type 1 and 2 diabetes at both neurological and molecular level.
  • 390
  • 17 Apr 2021
Topic Review
COVID-19 and Postural Control
Subjects who had experienced olfactory dysfunction or respiratory distress during COVID-19 demonstrate symptoms of balance deficits after COVID-19 recovery, and the analysis using rambling-trembling decomposition method might point at less efficient peripheral control. Monitoring for neurological sequelae of COVID-19 should be considered. 
  • 390
  • 21 Feb 2022
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