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Antifungals and Drug Resistance
Antifungal drugs prevent topical or invasive fungal infections (mycoses) either by stopping growth of fungi (termed fungistatic) or by killing the fungal cells (termed fungicidal). Antibiotics also prevent bacterial infections through either bacteriostatic or bactericidal mechanisms. These microorganisms successfully develop resistance against conventional drugs that are designed to kill or stop them from multiplying. When a fungus no longer responds to antifungal drug treatments and continues to grow, this is known as antifungal drug resistance. Bacteria have an amazing capacity to become resistant to antibiotic action as well, and the effectiveness of the scarce antifungal arsenal is jeopardised by this antibiotic resistance, which poses a severe threat to public health.
  • 1.7K
  • 21 Oct 2022
Topic Review
Eidetic Imagery
An eidetic image is a type of vivid mental image, not necessarily derived from an actual external event or memory. It was identified in the early twentieth century as a distinct phenomenon by psychologists including E.R. Jaensch, Heinrich Klüver, Gordon Allport and Frederic Bartlett. Later, Akhter Ahsen located eidetic imagery in a structuralist context, and explored its therapeutic applications: psychotherapists sometimes encourage their clients to create and explore eidetic images as a way of coming to terms with past life events. Eidetic imagery has also been studied in relation to the creative arts.
  • 1.1K
  • 21 Oct 2022
Topic Review
Transactional Analysis
Transactional analysis (TA) is a psychoanalytic theory and method of therapy wherein social interactions (or “transactions”) are analyzed to determine the ego state of the communicator (whether parent-like, childlike, or adult-like) as a basis for understanding behavior. In transactional analysis, the communicator is taught to alter the ego state as a way to solve emotional problems. The method deviates from Freudian psychoanalysis which focuses on increasing awareness of the contents of subconsciously held ideas. Eric Berne developed the concept and paradigm of transactional analysis in the late 1950s.
  • 991
  • 20 Oct 2022
Topic Review
External Beam Radiotherapy
External beam radiotherapy (EBRT) is the most common form of radiotherapy (radiation therapy). The patient sits or lies on a couch and an external source of ionizing radiation is pointed at a particular part of the body. In contrast to brachytherapy (sealed source radiotherapy) and unsealed source radiotherapy, in which the radiation source is inside the body, external beam radiotherapy directs the radiation at the tumour from outside the body. Orthovoltage ("superficial") X-rays are used for treating skin cancer and superficial structures. Megavoltage X-rays are used to treat deep-seated tumours (e.g. bladder, bowel, prostate, lung, or brain), whereas megavoltage electron beams are typically used to treat superficial lesions extending to a depth of approximately 5 cm (increasing beam energy corresponds to greater penetration). X-rays and electron beams are by far the most widely used sources for external beam radiotherapy. A small number of centers operate experimental and pilot programs employing beams of heavier particles, particularly protons, owing to the rapid dropoff in absorbed dose beneath the depth of the target.
  • 952
  • 19 Oct 2022
Topic Review
Grief Counseling
Grief counseling is a form of psychotherapy that aims to help people cope with the physical, emotional, social, spiritual, and cognitive responses to loss. These experiences are commonly thought to be brought on by a loved person's death, but may more broadly be understood as shaped by any significant life-altering loss (e.g., divorce, home foreclosure, or job loss). Grief counselors believe that everyone experiences and expresses grief in personally unique ways that are shaped by family background, culture, life experiences, personal values, and intrinsic beliefs. They believe that it is not uncommon for a person to withdraw from their friends and family and feel helpless; some might be angry and want to take action. Some may laugh while others experience strong regrets or guilt. Tears or the lack of crying can both be seen as appropriate expressions of grief. Grief counselors know that one can expect a wide range of emotion and behavior associated with grief. Some counselors believe that in virtually all places and cultures, the grieving person benefits from the support of others. Further, grief counselors believe that where such support is lacking, counseling may provide an avenue for healthy resolution. Grief counselors also believe that where the process of grieving is interrupted, for example, by the one who is grieving having to simultaneously deal with practical issues of survival or by their having to be the strong one who is striving to hold their family together, grief can remain unresolved and later resurface as an issue for counseling.
  • 574
  • 19 Oct 2022
Topic Review
Pulvermacher's Chain
The Pulvermacher chain, or in full as it was sold the Pulvermacher hydro-electric chain, was a type of voltaic battery sold in the second half of the 19th century for medical applications. Its chief market was amongst the numerous quack practitioners who were taking advantage of the popularity of the relatively new treatment of electrotherapy, or "electrification" as it was then known. Its unique selling point was its construction of numerous linked cells, rendering it mechanically flexible. A variant intended to be worn wrapped on parts of the body for long periods was known as Pulvermacher's galvanic chain or electric belt. The Pulvermacher Company attracted a great deal of antagonism from the medical community due to their use of the names of well-known physicians in their advertising without permission. The nature of their business; in selling to charlatans and promoting quack practices also made them unpopular with the medical community. Despite this, the Pulvermacher chain was widely reported as a useful source of electricity for medical and scientific purposes, even amongst the most vocal critics of the Pulvermacher Company.
  • 244
  • 18 Oct 2022
Topic Review
Effects of Photo-Crosslinking Hydrogels in Wound Healing
Wound healing is a dynamic physiological process, including three stages: inflammation, tissue formation, and remodeling. The quality of wound healing is affected by many topical and systemic factors, while any small factor may affect the process. Therefore, improving the quality of wound healing is a complex and arduous challenge. Photo-crosslinking reaction using visible light irradiation is a novel method for hydrogel preparation. Photo-crosslinking hydrogels can be controlled in time and space, and are not interfered by temperature conditions, which have been widely used in the fields of medicine and engineering. 
  • 329
  • 18 Oct 2022
Topic Review
Community Counseling
Guidance and counseling is a process of helping an individual become fully aware of his/ herself and the ways in which he is responding to the influence of his/her environment. Counseling is a generic term for any of professional counseling that treats dysfunction occurring within a group of related people. This term describes a preventive system of counseling that works to combat psychological impairment through the improvement and development of community support. A community is defined as a group of interacting individuals who share a commonality. This commonality can be anything from location of residence to career interest, but a community counselor will use this common characteristic to council groups of people.
  • 4.6K
  • 17 Oct 2022
Topic Review
Complication
A complication in medicine, or medical complication, is an unfavorable result of a disease, health condition, or treatment. Complications may adversely affect the prognosis, or outcome, of a disease. Complications generally involve a worsening in severity of disease or the development of new signs, symptoms, or pathological changes which may become widespread throughout the body and affect other organ systems. Thus, complications may lead to the development of new diseases resulting from a previously existing disease. Complications may also arise as a result of various treatments. The development of complications depends on a number of factors, including the degree of vulnerability, susceptibility, age, health status, and immune system condition. Knowledge of the most common and severe complications of a disease, procedure, or treatment allow for prevention and preparation for treatment if they should occur. Complications are not to be confused with sequelae, which are residual effects that occur after the acute (initial, most severe) phase of an illness or injury. Sequelae can appear early in the development of disease or weeks to months later and are a result of the initial injury or illness. For example, a scar resulting from a burn or dysphagia resulting from a stroke would be considered sequelae. In addition, complications should not be confused with comorbidities, which are diseases that occur concurrently but have no causative association.
  • 609
  • 17 Oct 2022
Topic Review
Risk Stratification in Patients with Pulmonary Embolism
Pulmonary thromboembolism is a very common cardiovascular disease, with a high mortality rate. This disease still represents a great challenge both in diagnosis and treatment. The heterogeneous clinical picture, often without pathognomonic signs and symptoms, represents a huge differential diagnostic problem even for experienced doctors. The decisions surrounding this therapeutic regimen also represent a major dilemma in the group of patients who are hemodynamically stable at initial presentation and have signs of right ventricular (RV) dysfunction proven by echocardiography and positive biomarker values (pulmonary embolism of intermediate–high risk).
  • 410
  • 14 Oct 2022
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