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Topic Review
Targeted Therapies for Familial Hypercholesterolemia
Several new targeted therapies were developed for familial hypercholesterolemia, and some are being tested to achieve the low-density lipoprotein (LDL)-C goals for high-/very-high-risk familial hypercholesterolemia (FH) patients as recommended by the ESC/EAS 2016–2019 guidelines. The advantage of targeted therapies is that they provide clinicians with the power to practice personalized or precision medicine with the aim of achieving better risk/benefit and cost/effectiveness of therapies.
  • 358
  • 15 Nov 2022
Topic Review
Evolution of Chemistries and Pharmaceutical Properties of ASOs
Myotonic dystrophy type 1 (DM1) is a dominant genetic disease in which the expansion of long CTG trinucleotides in the 3′ UTR of the myotonic dystrophy protein kinase (DMPK) gene results in toxic RNA gain-of-function and gene mis-splicing affecting mainly the muscles, the heart, and the brain. The CUG-expanded transcripts are a suitable target for the development of antisense oligonucleotide (ASO) therapies. Antisense therapy is an attractive strategy making it possible to target almost every gene by simply modifying the base sequence. 
  • 388
  • 15 Nov 2022
Topic Review
Art Therapy
Art therapy (not to be confused with arts therapy, which includes other creative therapies such as drama therapy and music therapy) is a distinct discipline that incorporates creative methods of expression through visual art media. Art therapy, as a creative arts therapy profession, originated in the fields of art and psychotherapy and may vary in definition. There are three main ways that art therapy is employed. The first one is called analytic art therapy. Analytic art therapy is based on the theories that come from analytical psychology, and in more cases, psychoanalysis. Analytic art therapy focuses on the client, the therapist, and the ideas that are transferred between the both of them through art. Another way that art therapy is utilized is art psychotherapy. This approach focuses more on the psychotherapist and their analysis of their clients artwork verbally. The last way art therapy is looked at is through the lens of art as therapy. Some art therapists practicing art as therapy believe that analyzing the client’s artwork verbally is not essential, therefore they stress the creation process of the art instead. In all of these different approaches to art therapy, the art therapist's client goes on the journey to delve into their inner thoughts and emotions by the use of paint, paper and pen, clay, sand, or maybe even fabric. Art therapy can be used to help people improve cognitive and sensory motor function, self-esteem, self awareness, emotional resilience. It may also aide in resolving conflicts and reduce distress. Current art therapy includes a vast number of other approaches such as person-centered, cognitive, behavior, Gestalt, narrative, Adlerian, and family. The tenets of art therapy involve humanism, creativity, reconciling emotional conflicts, fostering self-awareness, and personal growth.
  • 1.5K
  • 14 Nov 2022
Topic Review
High-Risk Pregnancy
A high-risk pregnancy is one where the mother or the fetus has an increased risk of adverse outcomes compared to uncomplicated pregnancies. No concrete guidelines currently exist for distinguishing “high-risk” pregnancies from “low-risk” pregnancies, however there are certain studied conditions that have been shown to put the mother or fetus at a higher risk of poor outcomes. These conditions can be classified into three main categories: health problems in the mother that occur before she becomes pregnant, health problems in the mother that occur during pregnancy, and certain health conditions with the fetus. In 2012, the CDC estimated that there were approximately 65,000 pregnancies deemed "high-risk" in the United States.
  • 260
  • 14 Nov 2022
Topic Review
Morita Therapy
Morita therapy is an ecological, purpose-centered, response-oriented therapy created through case-based research by Shoma Morita, M.D. (1874–1938). Morita developed his theory of consciousness and medically-grounded four-stage progressive therapeutic method with rigor. The goal of Morita therapy is to have the patient accept life as it is. This does not mean that the patient cannot set and achieve goals, but be able to be satisfied with their life in the moment. Morita therapy places an emphasis on letting nature take its course. This is not to say that patients should be resigned to their mental illness but to respect the laws of nature. Feeling emotions is a law of nature according to Morita therapy. Morita therapy helps its patients understand that experiencing emotions, positive or negative, is a facet of being a human being. Morita describes his own therapy as follows: Morita therapy was originally developed to address shinkeishitsu, an outdated term used in Japan to describe patients who have various types of anxiety. Morita therapy was designed not to completely rid the patient of shinkeishitsu but to lessen the damaging effects. While Morita therapy has been described as cognate to Albert Ellis's rational-emotive therapy, this description does not account for the ecological foundation of the therapy. Morita therapy also has commonalities with existential and cognitive behavioral therapy.
  • 799
  • 10 Nov 2022
Topic Review
Supportive Psychotherapy
Supportive psychotherapy is a psychotherapeutic approach that integrates various therapeutic schools such as psychodynamic and cognitive-behavioral, as well as interpersonal conceptual models and techniques. The aim of supportive psychotherapy is to reduce or to relieve the intensity of manifested or presenting symptoms, distress or disability. It also reduces the extent of behavioral disruptions caused by the patient's psychic conflicts or disturbances. Unlike in psychoanalysis, in which the analyst works to maintain a neutral demeanor as a "blank canvas" for transference, in supportive therapy the therapist engages in a fully emotional, encouraging, and supportive relationship with the patient as a method of furthering healthy defense mechanisms, especially in the context of interpersonal relationships. Supportive psychotherapy can be used as treatment for a variety of physical, mental, and emotional ailments, and consists of a variety of strategies and techniques in which therapists or other licensed professionals can treat their patients. The objective of the therapist is to reinforce the patient's healthy and adaptive patterns of thought behaviors in order to reduce the intrapsychic conflicts that produce symptoms of mental disorders.
  • 512
  • 09 Nov 2022
Topic Review
Human Givens
Human Givens is the name of a theory in psychotherapy formulated in the United Kingdom , first outlined by Joe Griffin and Ivan Tyrrell in the late 1990s. and amplified in the 2003 book Human Givens: A new approach to emotional health and clear thinking. The human givens organising ideas proffer a description of the nature of human beings, the 'givens' of human genetic heritage and what humans need in order to be happy and healthy. Human Givens therapy seeks to use a "client's strengths to enable them to get emotional needs met". It is advertised as "drawing from the best of person-centred counselling, motivational interviewing, cognitive behavioural therapy, psychoeducational approaches, interpersonal therapy, imaginal exposure and hypnotherapy". The Human Givens Institute has been accredited in the UK by the Professional Standards Authority for Health and Social Care (PSA).
  • 889
  • 09 Nov 2022
Topic Review
Histamine
Histamine [2-(4-imidazolyl)-ethylamine] is a biogenic amine that was first synthesized in the early 1900s. Histamine is a biogenic amine with numerous effects on many cell types, mediated by the activation of its four different histamine receptors (H1–H4Rs).
  • 445
  • 08 Nov 2022
Topic Review
The Challenge of Assessing Benefit-Risk of Older Drugs
Evidence-based pain therapy should rely on precisely defined and personalized criteria. This includes balancing the benefits and risks not only of single drugs but often requires complex between-drug comparisons. Non-steroidal anti-inflammatory drugs (NSAIDs) have been available for several decades and their use is described in an abundance of guidelines. Most of these guidelines recommend that ‘the selection of a particular NSAID should be based on the benefit-risk balance for each patient’. However, head-to-head studies are often lacking or of poor quality, reflecting the lower standards for clinical research and regulatory approval at the time. The inconsistency of approved indications between countries due to national applications adds to the complexity. Finally, a fading research interest once drugs become generic points to a general deficit in the post-marketing evaluation of medicines. Far from claiming completeness, this research illustrates the challenges that physicians encounter when trying to balance benefits and risks in a situation of incomplete and inconsistent data on longstanding treatment concepts. Ibuprofen and mefenamic acid, the most frequently sold NSAIDs in Austria, serve as examples. The illustrated principles are, however, not specific to these drugs and are generalizable to any comparison of older drugs in daily clinical practice. 
  • 375
  • 08 Nov 2022
Topic Review
Status Dynamic Psychotherapy
Status dynamic psychotherapy (SDT) is an approach to psychotherapy that was created by Peter G. Ossorio at the University of Colorado in the late 1960s as part of a larger system known as "descriptive psychology". Its distinguishing characteristic is that it does not focus on the factors traditionally targeted by psychotherapy such as the client’s behaviors, cognitions, insight into unconscious factors, and patterns of interaction with significant others. Instead, it focuses on bringing about changes in clients’ statuses; i.e., the positions that they occupy in relation to everything in their worlds, including themselves and aspects of themselves. Proponents of SDT maintain:
  • 238
  • 08 Nov 2022
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