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Topic Review
Apitherapy
Apitherapy is a complementary and alternative medicine approach, which involves the therapeutic use of various bee products including apilarnil (atomized drone larva) to prevent and treat various diseases.
  • 2.9K
  • 06 Oct 2020
Topic Review
Cytokines in Inflammatory Disease
This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines. Numerous studies have implicated that inflammatory cytokines exert important effects with regard to various inflammatory diseases, yet the reports on their specific roles are not always consistent. They can be used as biomarkers to indicate or monitor disease or its progress, and also may serve as clinically applicable parameters for therapies. Yet, their precise role is not always clearly defined. Thus, in this entry, researchers focus on the existing literature dealing with the biology of cytokines interleukin (IL)-6, IL-1, IL-33, tumor necrosis factor-alpha (TNF-α), IL-10, and IL-8. We will briefly focus on the correlations and role of these inflammatory mediators in the genesis of various inflammatory impacts.
  • 2.7K
  • 13 Oct 2021
Topic Review
Research on COVID-19
As of March, most of the world is under the order of a “lockdown” or “restricted movement control” whereby world leaders and medical experts believe that social isolation is the best option at reducing the spread of the highly infectious and novel disease, that is Coronavirus Disease (COVID-19). While this preventive measure is in place, various diagnostic kits and treatment strategies are being researched daily to diagnose and curb this disease quickly. This report summarizes the characteristics of the SARS-CoV-2 virus and evaluates the diagnostic kits and treatment drugs as well as vaccines that are either currently being used (RT-PCR) or in the clinical pipeline for safety and efficacy testing, respectively. The sooner efficient diagnosis and treatment can be made, the greater the number of lives will be saved.
  • 2.7K
  • 30 Oct 2020
Topic Review
Prevention and Treatment of COVID-19
Since the pandemic induced by the coronavirus SARS-CoV2 began to be spread throughout the whole world, many medical attempts to control the infection and avoid the high rate of mortality and morbidity have been made, collapsing the ICUs of many Hospitals. Many different treatments have been tested, but mortality reached very high values, especially in people in the middle/ elder age. Survivors usually develop important sequelae, even time after the infection had been controlled. In this article, we propose two different approaches to avoid the infection or mitigate their effects. One of them is based in the administration of GH, as preventive,  given its known effect on the production of lymphocytes and a high number of antibodies, as well as for helping in the recovery of the damaged organs. The other one is the administration of melatonin, both to prevent the infection and to act on inflammation once the disease is established. Both hormones are safe and can synergize when the damage to organs is established. GH administration has to be interrupted if the cytokine storm appears because the hormone can increase it. This is a novel approach that will be analyzed in extent, on scientific bases, throughout this article.  
  • 2.6K
  • 05 Nov 2020
Topic Review
MMP-13 in Osteoarthritis Treatment
Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the treatment of OA.
  • 2.4K
  • 07 May 2021
Topic Review
Histopathology of Choroidal Melanoma
Choroidal melanoma (CM), despite its rarity, is the most frequent intraocular malignancy. Over time, several histological variants of CM have been distinguished, including spindle A and B cell, fascicular, epithelioid and necrotic type. However, they have been progressively abandoned as having no prognostic value and currently, the American Joint Committee of Cancer (AJCC) classification identifies three CM cell types: spindle, epithelioid and mixed cell type. Other rare histological variants of CM include: (i) diffuse melanoma; (ii) clear cell; and (iii) balloon cell melanoma. Immunohistochemically, CMs are stained with Human Melanoma Black 45 (HMB45) antigen, S-100 protein, Melan-A (also known as melanoma antigen recognized by T cells 1/MART-1), melanocyte inducing transcription factor (MITF), tyrosinase, vimentin, and Sex determining region Y-Box 10 (SOX10). Several genetic and histopathological prognostic factors of CM have been reported in the literature, including epithelioid cell type, TNM staging, extraocular extension, monosomy 3 and 6p gain and loss of BAP-1 gene. The aim of this review was to summarize the histopathological, immunohistochemical and genetic features of CM, establishing “the state of the art” and providing colleagues with practical tools to promptly deal with patients affected by this rare malignant neoplasm.
  • 2.2K
  • 17 Dec 2020
Topic Review
IgG Transplacental Transfer: Benefits & Risks
IgG antibodies can cross and do cross the placenta during pregnancy from the mother to the fetus. The passage starts by the end of the first trimester and continues throughout pregnancy. This is a manner by which the fetus gets passive humoral immunity from the mother. In the early neonatal period, these transferred maternal antibodies will act as a defense and help the developing immunity of the baby. While they are short-lived and cleared from the neonatal circulation within several months, they may be very helpful. A down-side is that in certain maternal autoimmune conditions auto-antibodies seem to have the capacity to hijack the transfer mechanism. It is the case for anti-Ro antibodies. These antibodies are frequent in women with systemic lupus erythematosus and/or Sjogren syndrome. They can lead to fetal atrioventricular block.   
  • 2.2K
  • 17 Jan 2022
Topic Review
Exercise and Cartilage Regeneration Therapy
In response to exercise, articular chondrocytes increase their production of glycosaminoglycans, bone morphogenic proteins, and anti-inflammatory cytokines and decrease their production of proinflammatory cytokines and matrix-degrading metalloproteinases. These changes are associated with improvements in cartilage organization and reductions in cartilage degeneration. Studies in humans indicate that exercise enhances joint recruitment of bone marrow-derived mesenchymal stem cells and upregulates their expression of osteogenic and chondrogenic genes, osteogenic microRNAs, and osteogenic growth factors. Rodent experiments demonstrate that exercise enhances the osteogenic potential of bone marrow-derived mesenchymal stem cells while diminishing their adipogenic potential, and that exercise done after stem cell implantation may benefit stem cell transplant viability. Physical exercise also exerts a beneficial effect on the skeletal system by decreasing immune cell production of osteoclastogenic cytokines interleukin-1β, tumor necrosis factor-α, and interferon-γ, while increasing their production of antiosteoclastogenic cytokines interleukin-10 and transforming growth factor-β.
  • 2.1K
  • 28 Jan 2021
Topic Review
Syngeneic Tumor Models
Developments in cancer immunotherapy mean that complex cancer animal models which accurately relfect the tumor and its environment are required now more than ever. Mice remain good animals to investigate as they are relatively inexpensive, have short reproductive cycle, exhibit high tumor growth rates, and can be genetically modified. Despite being good models, some drugs which look promising in murine models still fail when trialed in humans. Increasing reliability is essential and the tumor model must reflect the tumor and its microenvironment including immune cells, to which the action of immunotherapeutic drugs are directed. This review investigates discusses the current immunocompetent and immunocompromised mouse models used to evaluate the effectiveness of immunotherapeutic agents, in particular chimeric antigen receptor (CAR) T-cells and immune checkpoint inhibitors.
  • 2.0K
  • 09 Nov 2020
Topic Review
Hereditary Hemochromatosis
The environment and the human genome are closely entangled and many genetic variations that occur in human populations are the result of adaptive selection to ancestral environmental (mainly dietary) conditions. However, the selected mutations may become maladaptive when environmental conditions change, thus becoming candidates for diseases. Hereditary hemochromatosis (HH) is a potentially lethal disease leading to iron accumulation mostly due to mutations in the HFE gene. Indeed, homozygosity for the C282Y HFE mutation is associated with the primary iron overload phenotype. However, both penetrance of the C282Y variant and the clinical manifestation of the disease are extremely variable, suggesting that other genetic, epigenetic and environmental factors play a role in the development of HH, as well as, and in its progression to end-stage liver diseases. Alcohol consumption and dietary habits may impact on the phenotypic expression of HFE-related hemochromatosis. Indeed, dietary components and bioactive molecules can affect iron status both directly by modulating its absorption during digestion and indirectly by the epigenetic modification of genes involved in its uptake, storage and recycling. Thus, the premise of this review is to discuss how environmental pressures led to the selection of HFE mutations and whether nutritional and lifestyle interventions may exert beneficial effects on HH outcomes and comorbidities.
  • 2.0K
  • 13 Nov 2021
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