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Topic Review
TRIMbody-Away Technique
TRIMbody-Away technique is a novel technology that could be utilized to acute and rapid destruction of specific intracellular proteins. This technology is based on a new type of fusion protein, designated as TRIMbody, by fusing the truncated form of tripartite motif 21 (TRIM21) with the nanobody. The truncated TRIM21 retained only the N-terminal RBCC domain and deleted the C-terminal PRY-SPRY domain. Therefore, TRIMbody possesses the functions of TRIM21 and mAbs, but has much smaller size. TRIMbody-Away technique could expand the landscape of the applications of degrader technologies and provide an alternative approach for potential therapeutic benefit in future.
  • 643
  • 25 Oct 2021
Topic Review
TRIM22. A Multitasking Antiviral Factor
Viral invasion of target cells triggers an immediate intracellular host defense system aimed at preventing further propagation of the virus. Viral genomes or early products of viral replication are sensed by a number of pattern recognition receptors, leading to the synthesis and production of type I interferons (IFNs) that, in turn, activate a cascade of IFN-stimulated genes (ISGs) with antiviral functions. Among these, several members of the tripartite motif (TRIM) family are antiviral executors.
  • 534
  • 29 Jul 2021
Topic Review
TRIM Proteins Family
TRIM (TRIpartite Motif-containing) proteins family is one of the largest groups of E3 ubiquitin ligases. Among them, interest in TRIM8 has greatly increased in recent years. TRIM8 functions are not limited to ubiquitination, and it has a role either as an oncogene or as a tumor suppressor gene, acting as a “double-edged weapon”. This is linked to its involvement in the selective regulation of three pivotal cellular signaling pathways: the p53 tumor suppressor, NF-κB and JAK-STAT pathways.
  • 410
  • 29 Mar 2021
Topic Review
TRIM
The tripartite motif (TRIM) gene family is a large group of E3 ubiquitin ligase proteins that can also have proteasome-independent functions. TRIM/RBCC are a large family of proteins that include more than 80 proteins, most of which act as E3 ligases and catalyze the direct transfer of Ubiquitin, SUMO and ISG15 on specific protein substrates. They are involved in oncogenesis processes and in cellular immunity.
  • 627
  • 19 May 2022
Topic Review
Tricyclodecan-9-yl-Xanthogenate (D609)
Tricyclodecan-9-yl xanthogenate (D609) is a synthetic tricyclic compound possessing a xanthate group. This xanthogenate compound is known for its diverse pharmacological properties. Over the last three decades, many studies have reported the biological activities of D609, including antioxidant, antiapoptotic, anticholinergic, anti-tumor, anti-inflammatory, anti-viral, anti-proliferative, and neuroprotective activities.
  • 516
  • 06 Apr 2022
Topic Review
Trichuriasis in Deer
Trichuris spp. are endoparasites found in a wide range of mammalian species. Some of these host species include humans, non-human primates, dogs, cats, pigs, wild ruminants and domesticated ruminants.
  • 472
  • 06 Jan 2022
Topic Review
Trichuriasis
Trichuriasis is the clinical disease of animals infected with the parasite of the genus Trichuris. This review attempts to present information on Trichuris spp. infestation in neo-tropical rodents that are utilized for meat consumption by humans
  • 900
  • 22 Feb 2021
Topic Review
Trichothiodystrophy
Trichothiodystrophy, which is commonly called TTD, is a rare inherited condition that affects many parts of the body. The hallmark of this condition is brittle hair that is sparse and easily broken. Tests show that the hair is lacking sulfur, an element that normally gives hair its strength.
  • 440
  • 23 Dec 2020
Topic Review
Trichostatin A
Trichostatin A (TSA) is a representative histone deacetylase (HDAC) inhibitor that modulates epigenetic gene expression by regulation of chromatin remodeling in cells. 
  • 725
  • 10 Aug 2021
Topic Review
Trichosporonosis
Trichosporonosis is an emerging concern in preterm neonates treated with broad-spectrum antimicrobials and indwelling catheters, and in children with hematologic malignant disease receiving prophylaxis or treatment with echinocandins given their lack of efficacy against this yeast. 
  • 449
  • 16 Feb 2022
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