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Topic Review
Naturally alkaloids as Antimicrobial agents
Antibiotic resistance is a serious threat to public health and new antimicrobial compounds are urgently needed. One of the most promising classes for the development of new antimicrobials are plant-derived alkaloids.
  • 1.8K
  • 25 Aug 2020
Topic Review
Fucoidan
Since the early life of humankind on the Earth, nature represents the most powerful source for his major needs from food, energy, and therapeutics. Oceans cover more than 70% of Earth’s surface, and therefore, they continue to offer exceptional scaffolds improving the quality of human life. According to the National Oceanic and Atmospheric Administration (United States Department of Commerce), marine microbes represent 98% of ocean biomass. From more than 300,000 described organisms, 12,000 novel compounds have been discovered attracting great interest in the last decades. Marine macroalgae are rich sources of either sulfated or non-sulfated polysaccharides with a wide range of interesting medical applications. Fucoidan is a marine polysaccharide isolated mainly from brown macroalgae with interesting and promising pharmacological activities. Several articles discussed and proved the potential, versatile, and promising pharmacological activities of fucoidans.
  • 1.8K
  • 17 Dec 2020
Topic Review
LINC Complex in Sperm Development
The LINC (LInker of Nucleoskeleton and Cytoskeleton) complex is localized within the nuclear envelope and consists of SUN (Sad1/UNc84 homology domain-containing) proteins located in the inner nuclear membrane and KASH (Klarsicht/Anc1/Syne1 homology domain-containing) proteins located in the outer nuclear membrane, hence linking nuclear with cytoplasmic structures. While the nucleoplasm-facing side acts as a key player for correct pairing of homolog chromosomes and rapid chromosome movements during meiosis, the cytoplasm-facing side plays a pivotal role for sperm head development and proper acrosome formation during spermiogenesis. A further complex present in spermatozoa is involved in head-to-tail coupling. An intact LINC complex is crucial for the production of fertile sperm, as mutations in genes encoding for complex proteins are known to be associated with male subfertility in both mice and men.
  • 1.8K
  • 04 Dec 2020
Topic Review
Sulfolobus Solfataricus
Saccharolobus solfataricus is a species of thermophilic archaeon. It was transferred from the genus Sulfolobus to the new genus Saccharolobus with the description of Saccharolobus caldissimus in 2018. It was first isolated and discovered in the Solfatara volcano (which it was subsequently named after) in 1980 by two Germans microbiologists Karl Setter and Wolfram Zillig, in Solfatara volcano (Pisciarelli-Campania, Italy). However, these organisms are not isolated to volcanoes but are found all over the world in places such as hot springs. The species grows best in temperatures around 80° Celsius, a pH level between 2 and 4, and enough sulfur for solfataricus to metabolize in order to gain energy. These conditions qualify it as an extremophile and it is specifically known as a thermoacidophile because of its preference to high temperatures and low pH levels and it is also in aerobic and heterotropic categories for its metabolic system. It usually has a spherical cell shape and it makes frequent lobes. Being an autotroph it receives energy from growing on sulfur or even a variety of organic compounds. Currently, it is the most widely studied organism that is within the Crenarchaeota branch. Solfataricus are researched for their methods of DNA replication, cell cycle, chromosomal integration, transcription, RNA processing, and translation. All the data points to the organism having a large percent of archaeal-specific genes, which showcases the differences between the three types of microbes: archaea, bacteria, and eukarya.
  • 1.8K
  • 04 Nov 2022
Topic Review
Silphium
The chemical composition of three Silphium species in the aspect of the possibility of their use for various purposes has been evaluated. The plant material of three Silphium species (S. perfoliatum, S. trifoliatum and S. integrifolium) was acquired from cultivation located in eastern Poland. The vegetative propagating material consisted of seeds and rhizomes. Content of protein (up to 22.9% in leaves of S. perfoliatum), amino acids (aspartic acid—up to 12.0%, glutamic acid—up to 9.5%, and leucine—up to 9.4%), fat (up to 4.2% in inflorescences of S. perfoliatum), cellulose (up to 42.9% in stems of S. trifoliatum), water-soluble sugars (up to 26.7% in rhizomes of S. perfoliatum) and mineral substances (ash up to 20.9% in stems of S. integrifolium, with significant levels of elements such as K, Ca, Mg, Fe, Mn) in the tested Silphium species can be an important criterion determining a positive evaluation of these plants as sources of alternative raw materials. The conducted research is meant to draw attention to the possibility of use of the biomass of three Silphium species as a potential source of ecological and renewable raw material for food, pharmaceuticals, feed and possibly also for energy generation purposes.
  • 1.8K
  • 02 Nov 2020
Topic Review
MAPK Pathways in Cancer Metastasis
Metastasis is perhaps the most common reason for treatment failure in cancer patients, as well as the leading cause of cancer-related death. Mitogen-activated protein kinase (MAPK) are serine/threonine-protein kinases that can be activated by a variety of extracellular stimuli including growth factors, cytokines, insulin, environmental factors, and oxidative and genotoxic stress. It is becoming increasingly clear that MAPKs are involved in all the steps required for hyperproliferating cells to develop into metastatic tumors. However, scholars are currently lacking in vivo data to fully understand how MAPK signaling pathways can affect the progression of metastatic disease. 
  • 1.8K
  • 26 May 2022
Topic Review
Bioferments
Bioferments are innovative ingredients extracted from natural raw materials by carrying out a fermentation process with appropriate strains of microorganisms. Mainly bioferments are made from plant-based raw materials. The spectrum of applications for bioferments is broad and includes properties such as skin whitening, antioxidant properties (blackberry, soybean, goji berry), anti-aging (red ginseng, black ginseng, Citrus unshiu peel), hydrating, and anti-allergic (aloe vera, skimmed milk).
  • 1.8K
  • 04 Aug 2022
Topic Review
Mixture Designs of Experiments
The experimental designs for mixtures are a subclass of experimental designs useful for studying the effects of ingredients/components in formulations. 
  • 1.8K
  • 04 Jun 2021
Topic Review
Gravitational Influence
Gravity constituted the only constant environmental parameter, during the evolutionary period of living matter on Earth. However, whether gravity has affected the evolution of species, and its impact is still ongoing.
  • 1.8K
  • 14 Jul 2021
Topic Review
Impact of COVID-19 on Social/Health/Economy
The COVID-19 pandemic is the most large-scale pandemic on earth this century, and the impact in all life sectors is devasting and directly affected human activity in the first wave. The impact on the economy, social care systems, and human relationships is causing an unprecedented global crisis. SARS-CoV-2 has a strong direct acute impact on population health, not only at the physiological level but also at the psychological level for those who suffer it, those close to them, and the general population, who suffer from the social consequences of the pandemic. In this line, the economic recession increased, even more, the social imbalance and inequity, hitting the most vulnerable families, and creating a difficult context for public institutions to address. 
  • 1.8K
  • 15 Jun 2021
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