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Topic Review
β-1,4-GalT-V and Cancer
β-1,4-GalTs are a family of glycosyltransferases, all having similar properties (i.e., they exclusively transfer galactose residues from a donor UDP-galactose via β-1,4 linkage to acceptor sugars, N-acetyl glucosamine (GlcNAc),glucose (Gl)c, and xylose(Xyl), which can be components of protein or lipids that have different functions).
  • 214
  • 08 Jan 2024
Topic Review
DNA Methylation
DNA methylation is a key epigenetic signature implicated in regulation of gene expression that occurs predominantly within CpG dinucleotides.
  • 185
  • 08 Jan 2024
Topic Review
The Link between SARS-CoV-2 Infection and Renal Cancer
Cancer has been described as a risk factor for greater susceptibility to SARS-CoV-2 infection and severe COVID-19, mainly for patients with metastatic disease. Conversely, to that reported for most solid and hematological malignancies, the few available clinical studies reported that the infection did not increase the risk of death in renal cancer patients. The expression on proximal tubular renal cells of the key players in cellular viral uptake, ACE2, TMPRSS2, and NRP1, seems to be the mechanism for the direct kidney injury seen in patients with COVID-19. Data from The Cancer Genome Atlas and experimental analyses on various renal cancer cell lines demonstrated that the above-reported receptors/cofactors are maintained by renal cancer cells. However, whether SARS-CoV-2 infection directly kills renal cancer cells or generates enhanced immunogenicity is a question worth investigating.
  • 159
  • 08 Jan 2024
Topic Review
Crop Fertigation in Closed Soilless Systems
Inappropriate fertilisation results in the pollution of water resources with nitrates and phosphates, eutrophication in surface water, emission of greenhouse gasses, and unwanted N deposition in natural environments, thereby harming the whole ecosystem. Cultivation in closed soilless systems entails recycling of the fertigation effluents thus eliminating nutrient emissions to the environment and concomitantly pollution of water resources with nitrates and phosphates.
  • 226
  • 08 Jan 2024
Topic Review
Droplet-Based Microfluidic High-Throughput Screening of Engineered Strains
Microfluidic technology has become an important high-throughput screening technology due to its fast speed, low cost, high automation, and high screening throughput, and it has developed rapidly. Droplet-based microfluidic high-throughput screening has been widely used in various fields, such as strain/enzyme activity screening, pathogen detection, single-cell analysis, drug discovery, and chemical synthesis, and has been widely applied in industries such as those involving materials, food, chemicals, textiles, and biomedicine. 
  • 204
  • 08 Jan 2024
Topic Review
Lactococcus lactis
Gram-positive cocci known as Lactococcus are found solely in pairs or in chains. They are catalase-negative, and facultatively anaerobic L-lactic acid is the main byproduct of the fermentation of glucose during the glycolytic pathway of L. lactis.
  • 250
  • 05 Jan 2024
Topic Review
New Foods in Enhancing Energy Security
Increasing energy security is a crucial component of achieving the Sustainable Development Goals (SDGs). Three main factors influence energy security: (1) the efficiency of resource use in energy production, (2) the extent of energy losses, and (3) the use of new energy sources. Novel food products can impact these factors. Assuring sustainable growth and development in the long run calls for technical, social, political, economic, ethical, and research integrity solutions to ensure a reliable supply of clean and affordable energy and nutritious food for everyone, which highly impact well-being and health.
  • 234
  • 05 Jan 2024
Topic Review
Molecular Dynamics of Early Pregnancy in Farm Animals
Infertility is a major problem in farm animals, which has a negative economic effect on farm industries. Infertility can be defined as the inability of animals to achieve a successful pregnancy. Early pregnancy is crucial to establish a successful pregnancy, and it is reported that 70–80% and 20–30% of total embryonic loss occur in cattle and pigs, respectively, during the first month of pregnancy.
  • 158
  • 05 Jan 2024
Topic Review
Heterogeneity of Colorectal Cancer Liver Metastasis
Colorectal cancer (CRC) is a disease with a high incidence and mortality rate. The number of new CRC cases worldwide reached 1.93 million in 2020, ranking third after breast cancer and lung cancer. The number of CRC-related deaths reached 940,000, making it the second most deadly tumor globally. In China, according to the 2016 national cancer statistics published by the National Cancer Center, a total of 4.06 million tumor patients were diagnosed in 2016, with approximately 408,000 being CRC patients. Among these cases, approximately 196,000 CRC patients died, accounting for 8.10% of the total.
  • 207
  • 05 Jan 2024
Topic Review
Proteomics Applications in Toxoplasma gondii
Toxoplasma gondii, a protozoan parasite with the ability to infect various warm-blooded vertebrates, including humans, is the causative agent of toxoplasmosis. This infection poses significant risks, leading to severe complications in immunocompromised individuals and potentially affecting the fetus through congenital transmission. A comprehensive understanding of the intricate molecular interactions between T. gondii and its host is pivotal for the development of effective therapeutic strategies. 
  • 204
  • 05 Jan 2024
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