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Topic Review
Biography
Topic Review
Climate Change and
Quercus alba
Biology
Quercus alba L., also known as white oak, eastern white oak, or American white oak, is a quintessential North American species within the white oak section (Quercus) of the genus Quercus, subgenus Quercus. This species plays a vital role in local and regional economies and as a keystone species in eastern North American forests. As a long-lived woody perennial covering an extensive natural range, Q. alba’s biology is shaped by a myriad of adaptations accumulated throughout its natural history. Populations of Q. alba are crucial repositories of genetic, genomic, and evolutionary insights, capturing the essence of successful historical adaptations and ongoing responses to contemporary environmental challenges in the Anthropocene. This intersection offers an exceptional opportunity to integrate genomic knowledge with the discovery of climate-relevant traits, advancing tree improvement, forest ecology, and forest management strategies.
143
19 Feb 2024
Topic Review
Monoclonal Antibodies
The development of severe multidrug-resistant bacterial infections has recently intensified because of the COVID-19 pandemic. According to the guidelines issued by the World Health Organization (WHO), routine antibiotic administration is not recommended for patients with supposed or confirmed mild SARS-CoV-2 infection or pneumonia, unless bacterial infection is clinically suspected.
248
19 Feb 2024
Topic Review
Genetic Marker Exploration for Livestock Vertebral Traits
In livestock breeding, the number of vertebrae has gained significant attention due to its impact on carcass quality and quantity. Variations in vertebral traits have been observed across different animal species and breeds, with a strong correlation to growth and meat production. Furthermore, vertebral traits are classified as quantitative characteristics. Molecular marker techniques, such as marker-assisted selection (MAS), have emerged as efficient tools to identify genetic markers associated with vertebral traits.
115
19 Feb 2024
Topic Review
Innovative Treatment against Polycystic Kidney Disease
Polycystic kidney disease (PKD) is the most common genetic form of chronic kidney disease (CKD), and it involves the development of multiple kidney cysts.
160
19 Feb 2024
Topic Review
Apoptosis Inhibitor 5 and Cancer
Apoptosis, or programmed cell death, is a fundamental process that maintains tissue homeostasis, eliminates damaged or infected cells, and plays a crucial role in various biological phenomena. The deregulation of apoptosis is involved in many human diseases, including cancer. One of the emerging players in the intricate regulatory network of apoptosis is apoptosis inhibitor 5 (API5), also called AAC-11 (anti-apoptosis clone 11) or FIF (fibroblast growth factor-2 interacting factor). While it may not have yet the same level of notoriety as some other cancer-associated proteins, API5 has garnered increasing attention in the cancer field, as elevated API5 levels are often associated with aggressive tumor behavior, resistance to therapy, and poor patient prognosis.
266
18 Feb 2024
Topic Review
Skin Cancer Survival Prediction Using Artificial Intelligence Techniques
The advancement in cancer research using high throughput technology and artificial intelligence (AI) is gaining momentum to improve disease diagnosis and targeted therapy. However, the complex and imbalanced data with high dimensionality pose significant challenges for computational approaches and multi-omics data analysis.
173
18 Feb 2024
Topic Review
Quantitative Vitamin A Analysis Approaches
Ensuring that animals receive a well-balanced diet and appropriate feed formulation can significantly enhance animal productivity, improve the quality of their products, and promote better animal welfare. Vitamin A, also known as retinol, is a vital micronutrient crucial for maintaining optimal health and well-being in livestock. It plays a central role in various physiological functions, including immune response regulation, vision maintenance, and cellular differentiation. Consequently, the accurate determination of vitamin A levels in animal feed and premixes is essential for ensuring animal health and production. Beyond preventing deficiencies and associated health issues, it forms the foundation for their overall growth and performance.
231
18 Feb 2024
Topic Review
Heterologous Expression and Production of Oxidoreductase Enzymes
Enzymes are biocatalysts with complex structures and specific catalytic mechanisms that determine their distinctive properties, such as high catalytic activity and selectivity of specific substrates. Oxidoreductase (OXR) enzymes are in high demand for biocatalytic applications in the food industry and cosmetics (glucose oxidase (GOx) and cellobiose dehydrogenase (CDH)), bioremediations (horseradish peroxidase (HRP) and laccase (LAC)), and medicine for biosensors and miniature biofuel cells (GOx, CDH, LAC, and HRP). Therefore, scientists are still trying to find optimal fermentation formulas and, most recently, also using protein engineering and directed evolution for an additional increase in the yield of recombinant enzyme production.
156
18 Feb 2024
Topic Review
Targets on Astrocytes for the Treatment of ALS
Astrocytes, the most numerous and giant glial cells in the central nervous system (CNS), possess the unique ability to divide and proliferate throughout life. The cytosol of astrocytes exhibits a distinctive star-shaped morphology, housing a critical structural component known as the glial filament. Comprised of glial fibrillary acidic protein (GFAP), this intermediate filament is essential to the cytoskeleton and serves as a standard marker for astrocytes. Importantly, it is not entirely exclusive to astrocytes but also labels neural stem cells. Apart from organizing the blood–brain barrier (BBB) and supporting, sequestering, and isolating neurons, these cells perform a multitude of vital biological functions. These include the metabolism, synthesis, and secretion of neurotrophic factors, regulation of neurotransmitters and calcium homeostasis, maintenance of mitochondrial function, participation in nervous system and circuit development, and regulation of the immune status of the CNS. However, these functions are partially or wholly lost in reactive astrocytes. Amyotrophic lateral sclerosis (ALS) is a fatal illness characterized by the degeneration of upper and lower motor neurons (MNs), with an average survival of 3–5 years.
228
18 Feb 2024
Topic Review
Plant Responses to Stress Combinations
Stress combinations describe the simultaneous exposure of plants to two or more stresses. In the past, stress combinations were defined as simple combinations of two or at most three different stresses, and extensive research has been conducted in this realm. Given the escalating environmental complexity arising from heightened levels of various pollutants and erratic weather patterns due to climate change, studies indicate a substantial decline in plant growth and survival even when each stressor is at a relatively low level, as the number of stressors amplifies their effects. Therefore, studying plant responses to basic stress combinations alone is inadequate for intricate environments.Therefore, the concept of stress combinations has recently broadened, introducing a novel approach to studying plant responses to combined stresses termed “multifactorial stress combinations”(MFSCs). This term denotes combinations of three or more (n ≥ 3) stressors affecting the plant simultaneously or in succession. The simultaneous impacts on plants come from a multitude of stressors such as anthropogenic and non-anthropogenic biotic factors, climatic drivers, and soil-related abiotic factors.
136
18 Feb 2024
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