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Topic Review
WASF3
WASF3 (WAVE3), a Wiskott–Aldrich syndrome protein family member, appears to play a major role not only in the regulation of actin cytoskeleton dynamics but also in cancer cell invasion/metastasis. Blocking the WASF3-dependent metastatic signaling network remains an attractive and promising therapeutic option for the treatment of advanced tumors. 
  • 1.2K
  • 02 Feb 2021
Topic Review
WAS Gene
Wiskott-Aldrich syndrome is characterized by abnormal immune system function (immune deficiency), eczema (an inflammatory skin disorder characterized by abnormal patches of red, irritated skin), and a reduced ability to form blood clots. This condition primarily affects males.
  • 468
  • 24 Dec 2020
Biography
Warren P. Mason
Warren Perry Mason (September 28, 1900 – August 23, 1986) was an American electrical engineer and physicist at Bell Labs. A graduate of Columbia University, he had a prolific output, publishing four books and nearly a hundred papers. He was issued over two hundred patents, more than anyone else at Bell Labs. His work included acoustics, filters, crystals and ceramics, materials science, polyme
  • 474
  • 20 Dec 2022
Topic Review
Warming Climate and Boreal Forest
The southern boreal forests of North America are susceptible to large changes in composition as temperate forests or grasslands may replace them as the climate warms.
  • 492
  • 18 Jan 2022
Topic Review
Warfarin Sensitivity
Warfarin sensitivity is a condition in which individuals have a low tolerance for the drug warfarin.
  • 436
  • 23 Dec 2020
Topic Review
Warfarin Resistance
Warfarin resistance is a condition in which individuals have a high tolerance for the drug warfarin. Warfarin is an anticoagulant, which means that it thins the blood, preventing blood clots from forming.
  • 620
  • 23 Dec 2020
Biography
Ward Plummer
E. Ward Plummer is an American physicist. His main contributions are in surface physics of metals. Plummer is a Professor of Physics at Louisiana State University. Plummer received a Bachelor of Arts degree from Lewis and Clark College in 1962 and completed his Ph.D. degree in physics at Cornell University in 1967, working with Prof. Thor Rhodin. His thesis work was on atomic binding of 5-d t
  • 353
  • 10 Nov 2022
Topic Review
Warburgia ugandensis Leaf and Bark Extracts
In organic viticulture, copper-based fungicides are commonly used to suppress Downy Mildew infection, caused by the oomycete Plasmopara viticola. However, the frequent and intensive use of such fungicides leads to accumulation of the heavy metal in soil and nearby waters with adverse effects on the ecosystem. Therefore, alternative, organic fungicides against Downy Mildew are urgently needed to reduce the copper load in vineyards. In this entry, the use of Warburgia ugandensis Sprague (Family Canellacea) leaf and bark extracts as potential fungicides against Downy Mildew were evaluated. In vitro (microtiter) and in vivo (leaf discs, seedlings) tests were conducted, as well as field trials to determine the efficacy of the extracts against Downy Mildew. The results revealed an MIC100 of 500 µg/mL for the leaf extract and 5 µg/mL for the bark extract. Furthermore, experiments with leaf discs and seedlings demonstrated a strong protective effect of the extracts for up to 48 h under (semi-) controlled conditions. However, in field trials the efficacy of the extracts distinctly declined, regardless of the extracts’ origin and concentration.
  • 454
  • 28 Jan 2022
Topic Review
Warburg Effect in Colorectal Carcinogenesis
Colorectal cancer is one of the most leading causes of death worldwide. The Hallmark of colorectal cancer is the increase of glucose uptake and lactate production even in the presence of oxygen, a phenomenon known as the “Warburg effect”. 
  • 558
  • 26 Sep 2021
Topic Review
Warburg Effect
Otto Warburg discovered that cancer cells use a fermentative rather than oxidative metabolism even though the former is more inefficient in terms of energy production per molecule of glucose. Cancer cells increase the use of this fermentative metabolism even in the presence of oxygen, and this process is called aerobic glycolysis or the Warburg effect.
  • 420
  • 14 Jun 2023
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