Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Biography
Gerard K. O'Neill
Gerard Kitchen O'Neill (February 6, 1927 – April 27, 1992) was an American physicist and space activist. As a faculty member of Princeton University, he invented a device called the particle storage ring for high-energy physics experiments.[1] Later, he invented a magnetic launcher called the mass driver.[2] In the 1970s, he developed a plan to build human settlements in outer space, including
  • 910
  • 30 Nov 2022
Topic Review
Essential Oils as Antimicrobials
Essential oil is a term reserved for those compounds that are defined by the International Organization for Standardization (ISO) in their ISO 9235. These kinds of compounds are complex mixtures originated from the secondary metabolism, produced by the glandular trichomes, and in different secretory structures. They can be composed by terpenes, associated or not to other components, generally volatile and that provides an odor to the vegetable. These compounds have (with exceptions) a density lower than water density and are usually presented in liquid form. Besides, essential oils are hydrophobic compounds, soluble in alcohol (among others) and only a little soluble in water.
  • 910
  • 14 Jan 2021
Topic Review
Precision Agriculture for Farming
Precision agriculture (PA) is a technology-enabled, data-driven approach to farming management that observes, measures, and analyzes the needs of individual fields and crops. Precision livestock farming (PLF), relying on the automatic monitoring of individual animals, is used for animal growth, milk production, and the detection of diseases as well as to monitor animal behavior and their physical environment, among others.
  • 910
  • 18 Oct 2021
Topic Review
Immunosuppressive Cells
Tumor-associated macrophages (TAMs) produce various chemokines and angiogenic factors that promote tumor development, along with other immunosuppressive cells. TAMs generated from monocytes develop into functional, fully activated macrophages, and TAMs obtain various immunosuppressive functions to maintain the tumor microenvironment. The main population of TAMs comprises CD163+ M2 macrophages, and CD163+ TAMs release soluble (s)CD163 and several proinflammatory chemokines as a result of TAM activation to induce an immunosuppressive tumor microenvironment. Since direct blockade of PD1/PD-L1 signaling between tumor cells and tumor-infiltrating T cells is mandatory to induce an anti-immune response by anti-PD1 Abs. Understanding the crosstalk between TAMs and immunosuppressive cells is important for optimizing PD1 Ab-based immunotherapy.
  • 910
  • 03 Aug 2020
Topic Review
5HTTLPR Genetic Variant
Major Depressive Disorder (MDD) is a disease that involves biological, psychological, and social interactions. Studies have shown the importance of genetics contribution to MDD development. The SCL6A4 protein (5HTTLPR) functions transporting serotonin, a neurotransmitter linked to mood and emotion, to the synaptic cleft. Hence, this study seeks a better comprehension of the 5HTTLPR genetic variant association with MDD and its influence nervous system through a literature review.  
  • 913
  • 18 Nov 2020
Topic Review
HER2-Positive Breast Cancer
Up to one-third of all breast cancers are classified as the aggressive HER2-positive subtype, which is associated with a higher risk of recurrence compared to HER2-negative breast cancers. The HER2 hyperactivity associated with this subtype drives tumor growth by up-regulation of mTOR pathways and metabolic adaptation. Combination therapies that simultaneously target HER2 and mTOR improve clinical outcomes compared with HER2 inhibition alone. Drugs that mimic glucose deprivation in HER2-positive breast cancer patients have not been evaluated; however, preclinical studies have shown that the growth of HER2-positive breast tumors is reduced in response to combining the glycolytic inhibitor 2-DG with mTOR inhibitors.
  • 910
  • 02 Jul 2021
Topic Review
Polyphenols and Ischemic Stroke
Stroke is now the second leading cause of death worldwide, and is defined as an impairment in blood supply to the brain, and is linked to different cardiovascular dysfunctions. Two main types of stroke exist: ischemic stroke (due to clot-mediated blood vessel occlusion), which accounts for about 85% of all stroke cases, and hemorrhagic stroke (caused by blood vessel rupture), which accounts for 15% of total cases. Following the stroke, while the core region undergoes sudden death, the surrounding injured regions (called penumbra) may be able to recover their functions.
  • 910
  • 23 Jun 2021
Topic Review
Protein Glutathionylation and Glutaredoxin in Neurodegenerative Diseases
The brain is highly sensitive to oxidative stress due to its high oxygen consumption, abundance of unsaturated fatty acids which are prone to oxidation, and low antioxidant levels. It is a metabolically active and a high energy demanding organ that relies heavily on mitochondria for its energy needs. Majority of oxygen consumed by mitochondria during oxidative phosphorylation is coupled to ATP synthesis while ~4% contributes to the generation of superoxides which are further metabolized to reactive oxygen species (ROS). ROS modify proteins causing functional and structural damage to biomolecules. Prolonged exposure to reactive oxygen species (ROS) also damages DNA, mitochondrial membranes, and lipids, impairing its metabolic functions including synthesis of ATP, fatty acid oxidation and metabolism of essential biomolecules.
  • 911
  • 16 Dec 2022
Topic Review
Chronic Rhinosinusitis and Alzheimer’s Disease
Among millions of sufferers of chronic rhinosinusitis (CRS), the challenge is not only constantly coping with CRS-related symptoms, such as congested nose, sinus pain, and headaches, but also various complications, such as attention difficulties and possible depression. These complications suggest that neural activity in the central nervous system may be altered in those patients, leading to unexpected conditions, such as neurodegeneration in elderly patients. 
  • 909
  • 26 Oct 2021
Topic Review
Donkey Milk Properties and Mammary Gland Morphological Characteristics
Donkey milk (DM) is produced by the female animals of the house donkey (Equus asinus). DM is known for their nutritional and nutraceutical properties for human consumption. DM compared to milk from other dairy animals such cow, buffalo, goat and sheep is most likely to resemble human breast milk. The average daily milk yield of a female donkey over the entire lactation season is 1.57 kg/day and fluctuated between 0.20 and 6.00 kg/day. Furthermore, the average milk concentration of fat, protein, lactose, total solids and ash in DM are 0.63%, 1.71%, 6.34%, 9.11% and 0.39%, respectively. It is noteworthy that DM is rich in whey proteins, polyunsaturated fatty acids such as linoleic acid C18:2 and linolenic acid C18:3 and vitamin C. In addition, the average lysozyme concentration of DM is approximately 1.07 g/L, similar to human milk (0.30-1.10 g/L). The high lysozyme content may be the cause of low bactarial count of DM and also makes this milk useful for preventing intestinal infections in infants. Due to the significantly lower casein content, many people with a cows milk protein allergy can tolerate DM, as they find DM do not trigger an allergy reaction.
  • 909
  • 15 Apr 2022
  • Page
  • of
  • 1814
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Video Production Service
Feedback