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Topic Review
JNKs in Development of Disease
c-Jun N-terminal kinases (JNKs) have emerged as suitable therapeutic strategies. In fact, it has been demonstrated that some unspecific JNK inhibitors exert antidiabetic and neuroprotective effects, albeit they usually show high toxicity or lack therapeutic value. In this sense, natural specific JNK inhibitors, such as Licochalcone A, are promising candidates. Nonetheless, research on the understanding of the role of each of the JNKs remains mandatory in order to progress on the identification of new selective JNK isoform inhibitors. In the present review, a summary on the current gathered data on the role of JNKs in pathology is presented, as well as a discussion on their potential role in pathologies like epilepsy and metabolic-cognitive injury. Moreover, data on the effects of synthetic small molecule inhibitors that modulate JNK-dependent pathways in the brain and peripheral tissues is reviewed.
  • 931
  • 23 Oct 2020
Topic Review
Marine Benthos and Corals
Researchers present thorough this review of the developments in the field, point out their current limitations and outline its timelines and unique potential. In order to do so, authors introduce the methods used in each of the advances in the application of deep learning (DL) to coral research that took place between the years: 2016–2018. DL has the unique capability of streamlining the description, analysis, and monitoring of coral reefs, saving time, and obtaining higher reliability and accuracy compared with error-prone human performance. Coral reefs are the most diverse and complex of marine ecosystems, undergoing a severe decline worldwide resulting from the adverse synergistic influences of global climate change, ocean acidification, and seawater warming, exacerbated by anthropogenic eutrophication and pollution. DL is an extension of some of the concepts originating from machine learning that join several multilayered neural networks. Machine learning refers to algorithms that automatically detect patterns in data. In the case of corals, these data are underwater photographic images. Based on “learned” patterns, such programs can recognize new images. The novelty of DL is in the use of state-of-art computerized image analyses technologies, and its fully automated methodology of dealing with large data sets of images. Automated Image recognition refers to technologies that identify and detect objects or attributes in a digital video or image automatically. Image recognition classifies data into selected categories out of many. Authors show that Neural Network methods are already reliable in distinguishing corals from other benthos and non-coral organisms. Automated recognition of live coral cover is a powerful indicator of reef response to slow and transient changes in the environment. Improving automated recognition of coral species, DL methods already recognize the decline of coral diversity due to natural and anthropogenic stressors. Diversity indicators can document the effectiveness of reef bioremediation initiatives. Authors explored the current applications of deep learning for corals and benthic image classification by discussing the most recent studies conducted by researchers. Authors review the developments in the field, point out their current limitations, and outline their timelines and unique potential. Authors also discussed a few future research directions in the fields of deep learning. Future needs are the age detection of single species, in order to track trends in their population recruitment, decline, and recovery. Fine resolution, at the polyp level, is still to be developed, in order to allow separation of species with similar macroscopic features. That refinement of DL will allow such comparisons and their analyses. Authors conclude that the usefulness of future, more refined automatic identification will allow reef comparison, and tracking long term changes in species diversity. The hitherto unused addition of intraspecific coral color parameters will add the inclusion of physiological coral responses to environmental conditions and change thereof. The core aim of this review was to underscore the strength and reliability of the DL approach for documenting coral reef features based on an evaluation of the currently available published uses of this method. Authors expect that this review will encourage researchers from computer vision and marine societies to collaborate on similar long-term joint ventures.
  • 931
  • 30 Oct 2020
Topic Review
Cyclic Vomiting Syndrome
Cyclic vomiting syndrome is a disorder that causes recurrent episodes of nausea, vomiting, and tiredness (lethargy). This condition is diagnosed most often in young children, but it can affect people of any age.
  • 931
  • 24 Dec 2020
Topic Review
Epithelial Cells in Environmental-Associated Airway Diseases
People are exposed to contaminants through the respiratory tract and skin; they first reach the bloodstream and, subsequently, the organs, causing more or less serious damage to health. Thus, the effects of atmospheric pollution affect the respiratory tract with acute symptoms and the circulatory system with cardiovascular events, leading to hospitalizations and mortality. In addition to the acute effects, long-term effects can also be had, including an alteration of lung function in adults, children, and adolescents. Specifically, in children and adolescents, chronic exposure to air pollution is associated with a reduction in forced vital capacity (FVC), which correlates with age and can be interpreted as a reduction in the lung growth and respiratory function of the lower airways. Children, together with elderly persons, are the most sensitive subjects to environmental pollution; to these are added subjects with chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Emerging contaminants induce pulmonary toxicity by promoting an inflammatory response in lung epithelial cells.
  • 931
  • 15 Mar 2022
Topic Review
α-Synuclein in Gene Expression
α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein plays a central role in both sporadic and familial Parkinson’s disease (PD) via a gain-of-function mechanism. Because of this, several recent strategies propose to decrease α-Syn levels in PD patients.
  • 931
  • 13 Aug 2021
Topic Review
Resveratrol in Aging COVID-19 Patients
COVID-19 symptoms are highly heterogeneous, and the patient may be asymptomatic or may present with mild to severe or fatal symptoms. Factors, such as age, sex, and comorbidities, are key determinants of illness severity and progression. Aging is accompanied by multiple deficiencies in interferon production by dendritic cells or macrophages in response to viral infections, resulting in dysregulation of inflammatory immune responses and excess oxidative stress. Age-related dysregulation of immune function may cause a more obvious pathophysiological response to SARS-CoV-2 infection in elderly patients and may accelerate the risk of biological aging, even after recovery. Resveratrol is a potent antioxidant with antiviral activity. 
  • 931
  • 14 Sep 2021
Topic Review
The Complement System
The complement system is part of the innate immune response, where it provides immediate protection from infectious agents and it plays a fundamental role in homeostasis. Complement dysregulation occurs in several diseases, where the tightly regulated proteolytic cascade turns offensive. Prominent examples are atypical hemolytic uremic syndrome, paroxysmal nocturnal hemoglobinuria and Alzheimer’s disease. Therapeutic intervention targeting complement activation may allow treatment of such debilitating diseases.
  • 930
  • 17 Mar 2021
Topic Review
Macrophages and Cholesterol-Dependent Cytolysins
Cholesterol-dependent cytolysins (CDCs) are key virulence factors involved in many lethal bacterial infections, including pneumonia, necrotizing soft tissue infections, bacterial meningitis, and miscarriage. Host responses to these diseases involve myeloid cells, especially macrophages. Macrophages use several systems to detect and respond to cholesterol-dependent cytolysins, including membrane repair, mitogen-activated protein (MAP) kinase signaling, phagocytosis, cytokine production, and activation of the adaptive immune system. However, CDCs also promote immune evasion by silencing and/or destroying myeloid cells. While there are many common themes between the various CDCs, each CDC also possesses specific features to optimally benefit the pathogen producing it.
  • 930
  • 09 Nov 2020
Topic Review
Veterinary Drug Residues
Veterinary drugs are substances or mixtures used for the prevention, treatment, or diagnosis of animal diseases or for purposeful regulation of animal physiological functions
  • 930
  • 10 Jun 2021
Topic Review
SARS-CoV-2 Nucleocapsid Protein
SARS-CoV-2 nucleocapsid protein (NCoV2) plays a key role in various processes related to the viral replication cycle such as the RNA genome packaging, interaction with other viral proteins. It has thus been a target for new drug development.
  • 930
  • 27 May 2021
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