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Topic Review
Targeting Gut Microbial Biofilms
Colorectal cancer (CRC) is a global public health issue which poses a substantial humanistic and economic burden on patients, healthcare systems and society. In recent years, intestinal dysbiosis has been suggested to be involved in the pathogenesis of CRC, with specific pathogens exhibiting oncogenic potentials such as Fusobacterium nucleatum, Escherichia coli and enterotoxigenic Bacteroides fragilis having been found to contribute to CRC development. More recently, it has been shown that initiation of CRC development by these microorganisms requires the formation of biofilms. Gut microbial biofilm forms in the inner colonic mucus layer and is composed of polymicrobial communities. Biofilm results in the redistribution of colonic epithelial cell E-cadherin, increases permeability of the gut and causes a loss of function of the intestinal barrier, all of which enhance intestinal dysbiosis. This literature review aims to compile the various strategies that target these pathogenic biofilms and could potentially play a role in the prevention of CRC. We explore the potential use of natural products, silver nanoparticles, upconverting nanoparticles, thiosalicylate complexes, anti-rheumatic agent (Auranofin), probiotics and quorum-sensing inhibitors as strategies to hinder colon carcinogenesis via targeting colon-associated biofilms.
  • 1.0K
  • 22 Oct 2020
Topic Review
Thalattosaur
Thalattosauria (meaning "ocean lizards") is an extinct order of prehistoric marine reptiles that lived in the middle to late Triassic period. Thalattosaurs were diverse in size and shape, and are divided into two superfamilies: Askeptosauroidea and Thalattosauroidea. Askeptosauroids were endemic to the Tethys Ocean, their fossils have been found in Europe and China, and they were likely semiaquatic fish eaters with straight snouts and decent terrestrial abilities. Thalattosauroids were more specialized for aquatic life and most had unusual downturned snouts and crushing dentition. Thalattosauroids lived along the coasts of both Panthalassa and the Tethys Ocean, and were most diverse in China and western North America. The largest species of thalattosaurs grew to over 4 meters (13 feet) in length, including a long, flattened tail utilized in underwater propulsion. Although thalattosaurs bore a superficial resemblance to lizards, their exact relationships are unresolved. They are widely accepted as diapsids, but experts have variously placed them on the reptile family tree among Lepidosauromorpha (lizards and their relatives), Archosauromorpha (archosaurs and their relatives), ichthyosaurs, and/or other marine reptiles.
  • 1.0K
  • 25 Nov 2022
Topic Review
Receptor-Dependent Apoptotic Pathway
Apoptosis is a process of programmed cell death which has an important role in tissue and organ homeostasis and in the control of organism development. Two main signaling pathways are involved in regulation of apoptosis: the mitochondrial dependent intrinsic pathway and death receptor dependent extrinsic pathway. The receptors are members of the tumor necrosis factor receptor superfamily (TNFRSF).The extrinsic apoptotic pathway triggers apoptosis by binding of ligands to death receptors, which leads to formation of a death-inducing signaling complex (DISC) and in consequence, caspase activation. This pathway and its subpathways and regulatory factors and linkages to the other cellular signaling events are briefly presented.
  • 1.0K
  • 30 Oct 2020
Biography
Frances E. Allen
Frances Elizabeth "Fran" Allen (born August 4, 1932) is an American computer scientist and pioneer in the field of optimizing compilers.[1][2][3] Allen was the first female IBM Fellow and in 2006 became the first woman to win the Turing Award.[4] Her achievements include seminal work in compilers, program optimization, and parallelization.[5] Since 2002, she has been a Fellow Emerita from IBM.[6
  • 1.0K
  • 24 Nov 2022
Topic Review
The Invasive Fireweed (Senecio madagascariensis Poir)
Senecio madagascariensis originates from southern Africa but it has been introduced to several other countries including Australia. Climatic suitability suggests that there are large areas around the world suitable for the weed’s growth where it is currently not present. The weed poses a major threat to livestock industries in these countries through its ability to reduce pasture production and poison animals. A range of control techniques has been used to try and manage S. madagascariensis. Besides using traditional approaches, the use of competitive pastures and more tolerant livestock (such as sheep and goats) are some of the other options recommended as part of an integrated approach. 
  • 1.0K
  • 17 Jan 2022
Topic Review
Genetic characterization in Korean horse
In modern times, horse breeds, mostly in horse racing, are the Thoroughbred varieties obtained by breeding three Godolphin Arabians with British mares in England. Especially in Jeju Island, Korea, Jeju horses have been introduced from Mongolia since the 13th century. They have contributed a lot to the agricultural community, but their population has been rapidly decreasing due to rapid agricultural industrialization. Therefore, we sympathize with Jeju horse-specific genetic variation and compare and analyze evolutionary correlations by utilizing Whole Genome Sequencing analysis to evaluate the genetic diversity of Jeju horses and preserve genetic information. We explored Jeju horse-specific genetic differences through a comparative analysis of large-capacity genomic data between the public database and a Thoroughbred variety. In order to adapt to the barren external environment, it is predicted that Jeju horses have experienced strong positive selection in the direction of accumulating many genetic variations, enough to cause functional differences in the eqCD1a6 gene to have an efficient immune function. In addition, we further validate the Jeju horse-specific single nucleotide polymorphisms in the eqCD1a6 gene by employing the digital PCR method, a diagnostic technique for genetic variations.
  • 1.0K
  • 08 Jul 2021
Topic Review
Ethylene
Salinity stress is one of the major threats to agricultural productivity across the globe. Research in the past three decades, therefore, has focused on analyzing the effects of salinity stress on the plants. Evidence gathered over the years supports the role of ethylene as a key regulator of salinity stress tolerance in plants. This gaseous plant hormone regulates many vital cellular processes starting from seed germination to photosynthesis for maintaining the plants’ growth and yield under salinity stress. Ethylene modulates salinity stress responses largely via maintaining the homeostasis of Na+/K+, nutrients, and reactive oxygen species (ROS) by inducing antioxidant defense in addition to elevating the assimilation of nitrates and sulfates. Moreover, a cross-talk of ethylene signaling with other phytohormones has also been observed, which collectively regulate the salinity stress responses in plants.
  • 1.0K
  • 09 Jul 2021
Topic Review
Origin of SMTP
Stachybotrys microspora triprenyl phenol (SMTP) is a large family of small molecules derived from the fungus S. microspora. SMTP acts as a zymogen modulator (specifically, plasminogen modulator) that alters plasminogen conformation to enhance its binding to fibrin and subsequent fibrinolysis. Certain SMTP congeners exert anti-inflammatory effects by targeting soluble epoxide hydrolase. SMTP congeners with both plasminogen modulation activity and anti-inflammatory activity ameliorate various aspects of ischemic stroke in rodents and primates. A remarkable feature of SMTP efficacy is the suppression of hemorrhagic transformation, which is exacerbated by conventional thrombolytic treatments.
  • 1.0K
  • 29 Jan 2021
Topic Review
Description and Phytoconstituents of Sapindus mukorossi Gaertn.
Sapindus mukorossi Gaertn., also called the washnut, is a tropical tree of the Sapindaceae family. The plant owes its name to its cleaning and washing properties used by the local population as a natural detergent. The most important ingredients of the plant are triterpenoid saponins contained in many parts of the plant, inducing fruits, galls, or roots. The tree also contains other valuable, biologically active compounds that are obtained by extraction methods. Raw or purified extract and isolated saponins are valuable plant products that can be used in the food, pharmaceutical, cosmetic, and chemical industries.
  • 1.0K
  • 20 Sep 2022
Topic Review
Mechanisms of Ferroptosis
Ferroptosis, mainly mediated by iron-dependent lipid peroxidation, is closely linked to multiple physiological and pathological processes in humans and animals, including cancer, arteriosclerosis, ischemia-reperfusion injury, neurodegenerative diseases, and acute renal failure.
  • 1.0K
  • 10 Dec 2021
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