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Topic Review
Sarcopenia
Sarcopenia, a geriatric disease characterized by a progressive loss of skeletal muscle mass and loss of muscle function, consists of a rising, often undiagnosed health problem.
  • 1.1K
  • 13 Jan 2022
Topic Review
Pre-mRNA Splicing
Pre-mRNA splicing is an essential process for gene expression in higher eukaryotes, which requires a high order of accuracy. Mutations in splicing factors or regulatory elements in pre-mRNAs often result in many human diseases. Myelodysplastic syndrome (MDS) is a heterogeneous group of chronic myeloid neoplasms characterized by many symptoms and a high risk of progression to acute myeloid leukemia. Recent findings indicate that mutations in splicing factors represent a novel class of driver mutations in human cancers and affect about 50% of Myelodysplastic syndrome (MDS) patients. Somatic mutations in MDS patients are frequently found in genes SF3B1, SRSF2, U2AF1, and ZRSR2. Interestingly, they are involved in the recognition of 3′ splice sites and exons. It has been reported that mutations in these splicing regulators result in aberrant splicing of many genes.
  • 1.1K
  • 12 Aug 2021
Topic Review
Sparrow
Sparrows are a family of small passerine birds. They are also known as true sparrows, or Old World sparrows, names also used for a particular genus of the family, Passer. They are distinct from both the American sparrows, in the family Passerellidae, and from a few other birds sharing their name, such as the Java sparrow of the family Estrildidae. Many species nest on buildings and the house and Eurasian tree sparrows, in particular, inhabit cities in large numbers, so sparrows are among the most familiar of all wild birds. They are primarily seed-eaters, though they also consume small insects. Some species scavenge for food around cities and, like gulls or rock doves will happily eat virtually anything in small quantities.
  • 1.1K
  • 05 Dec 2022
Topic Review
Alpha-Emitting Radionuclides in Wild Mushrooms
Alpha-emitting radioisotopes are the most radiotoxic nuclides among all radionuclides. Especially medium- and long-living isotopes that enter the body, are hazardous metals of the greatest importance from the human life point of view. This review focuses on the most common natural and anthropogenic origin alpha-emitting radionuclides in wild mushrooms around the world. Mushrooms are considered as suitable bioindicators of environmental pollution with some metallic elements, for the reason they bioaccumulate a range of mineral ionic constituents including radioactive elements at different levels. Various species have different retain capacities of individual radionuclides. In turn, wild edible mushrooms are food products, mostly consumed regionally and also traded at an international scale. Mushrooms under pollution events situation might cause a risk to consumers due to exposure to highly radiotoxic decay particles produced by alpha emitters.
  • 1.1K
  • 20 Nov 2020
Topic Review
Sponge
Sponges, the members of the phylum Porifera (/pəˈrɪfərə/; meaning 'pore bearer'), are a basal animal clade as a sister of the diploblasts. They are multicellular organisms that have bodies full of pores and channels allowing water to circulate through them, consisting of jelly-like mesohyl sandwiched between two thin layers of cells. Sponges have unspecialized cells that can transform into other types and that often migrate between the main cell layers and the mesohyl in the process. Sponges do not have nervous, digestive or circulatory systems. Instead, most rely on maintaining a constant water flow through their bodies to obtain food and oxygen and to remove wastes. Sponges were first to branch off the evolutionary tree from the last common ancestor of all animals, making them the sister group of all other animals.
  • 1.1K
  • 22 Nov 2022
Topic Review
PP2A during Mitosis in Yeasts
Cell cycle regulation is largely based on protein phospho-dephosphorylation events, catalyzed by cyclin dependent kinases (Cdks) and phosphatases (PPases), respectively. During many years the Cdks were considered the main component of the cell cycle control system. Recently, the importance of the counteracting PPases has emerged. Research on yeast has provided many insights into such contribution. Here we present an overview of the protein phosphatase 2A family's roles during mitosis.
  • 1.1K
  • 23 Oct 2020
Topic Review
Plasmopara viticola
Plasmopara viticola, the causal agent of grapevine downy mildew, is a high risk pathogen associated with the development of fungicide resistance.
  • 1.1K
  • 26 Feb 2021
Topic Review
AMPs Nisin and Food Preservation
This study reports the application of antimicrobial peptides (AMPs) in food preservation because of their ability to inactivate spores and spore-forming bacteria. The review focused more on nisin, which is one of the sufficiently characterised AMPs for use in the food industry. The mechanisms of spore-forming bacteria inactivation, the effectiveness of using nisin AMP alone and the synergistic effect of combining AMPs with other non-thermal emerging technologies were explored.
  • 1.1K
  • 24 Sep 2021
Topic Review
The Honey Bee Apis mellifera
The honey bee Apis mellifera Linnaeus (1758) provides many benefits to humans and ecosystems. This species is an important pollinator in natural environments, which may help to preserve and restore the biodiversity of wild plants. On the other hand, pollination in agro-ecosystems by managed honey bee colonies may enhance crop yield and quality, meeting the increasing food demand. Beekeeping is also a high-valued and income-generating activity, which provides humans with honey as high-quality food as well as substances used as raw materials and in pharmaceuticals. In addition, the honey bee and its products are valuable bioindicators and bioaccumulators of environmental pollution: they provide valuable information on the impact of human activities, enabling the implementation of measures to mitigate risks to human and ecosystem health. The honey bee is also linked to many cultural ecosystem services and has a longstanding tradition in human culture, mysticism, and religion. Its popularity may be therefore used for educational purposes and to raise public awareness of important issues, such as the conservation of pollinator habitats and biodiversity.
  • 1.1K
  • 22 Jun 2022
Topic Review
Bidens pilosa (Asteraceae)
Bidens pilosa (Asteraceae) is an easy-to-grow medicinal herb which is also consumed as a leafy vegetable. This plant has been shown to have various health benefits and treatment of disease/conditions such as malaria,  hypertension, obesity and typhoid. Interestingly, some secondary metabolites such as hydroxycinnamic acid derivatives that have been identified in B. pilosa have been shown to have various bioactivities health such as anti-cancer properties, HIV-integrase inhibition and anti-diabetic properties. In this study, exogenous treatment of B. pilosa leaves with two signal molecules (MeJA and MeSA) induced metabolic changes, differentially perturbating the accumulation of these biologically important metabolites. Moreover, the perturbation of isomeric molecules, especially the cis geometrical isomers of HCA derivatives by both treatments, further point to the biological significance of these molecules during physiological responses to stress. The results highlight the possibility of using phytohormones to enhance the accumulation of bioactive secondary metabolites in this plant.
  • 1.1K
  • 06 Nov 2020
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