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Topic Review
Importance of Aflatoxins in Food and Agricultural Products
Contamination of agricultural products and foods by aflatoxin B1 (AFB1) is becoming a serious global problem, and the presence of AFB1 in edible oil is frequent and has become inevitable, especially in underdeveloped countries and regions. As AFB1 results from a possible degradation of aflatoxins and the interaction of the resulting toxic compound with food components, it could cause chronic disease or severe cancers, increasing morbidity and mortality.
  • 1.2K
  • 30 Sep 2022
Topic Review
Epigenetic Mechanisms of Plant Adaptation
Unlike animals, plants are immobile and could not actively escape the effects of aggressive environmental factors, such as pathogenic microorganisms, insect pests, parasitic plants, extreme temperatures, drought, and many others. To counteract these unfavorable encounters, plants have evolved very high phenotypic plasticity. In a rapidly changing environment, adaptive phenotypic changes often occur in time frames that are too short for the natural selection of adaptive mutations. Probably, some kind of epigenetic variability underlines environmental adaptation in these cases. Indeed, isogenic plants often have quite variable phenotypes in different habitats. There are examples of successful “invasions” of relatively small and genetically homogenous plant populations into entirely new habitats. The unique capability of quick environmental adaptation appears to be due to a high tendency to transmit epigenetic changes between plant generations. Multiple studies show that epigenetic memory serves as a mechanism of plant adaptation to a rapidly changing environment and, in particular, to aggressive biotic and abiotic stresses. In wild nature, this mechanism underlies, to a very significant extent, plant capability to live in different habitats and endure drastic environmental changes. In agriculture, a deep understanding of this mechanism could serve to elaborate more effective and safe approaches to plant protection.
  • 1.2K
  • 02 Nov 2020
Biography
Nakayama Miki
Nakayama Miki (中山 みき, 18 April 1798 – 26 January 1887 by the Japanese calendar[1]) was a nineteenth-century Japanese farmer and religious leader. She is the primary figure of the Japanese new religion Tenrikyo. Followers, who refer to her as Oyasama (おやさま), believe that she was settled as the Shrine of Tsukihi from the moment she experienced a divine revelation in 1838 until h
  • 1.2K
  • 15 Nov 2022
Topic Review
Abiotic Stress Response in Cereal Crops
Cereals have evolved various tolerance mechanisms to cope with abiotic stress. Understanding the abiotic stress response mechanism of cereal crops at the molecular level offers a path to high-yielding and stress-tolerant cultivars to sustain food and nutritional security. In this regard, enormous progress has been made in the omics field in the areas of genomics, transcriptomics, and proteomics. Omics approaches generate a massive amount of data, and adequate advancements in computational tools have been achieved for effective analysis. 
  • 1.2K
  • 09 Nov 2022
Biography
Ronald McNair
Ronald Erwin McNair (October 21, 1950 – January 28, 1986) was an American physicist and NASA astronaut. He died during the launch of the Space Shuttle Challenger on mission STS-51-L, in which he was serving as one of three mission specialists. He is survived by his wife, Cheryl, and two children. His kids were Jay Charey Mcnair (Daughter) and Reginald Ervin Mcnair (son) Born October 21, 195
  • 1.2K
  • 03 Jan 2023
Topic Review
Archaea Pigments
Archaea represent a resource of great potential for the identification of new metabolites because of their adaptation to extreme environmental conditions and their original metabolic pathways, allowing the synthesis of unique biomolecules. Archaea also represent a valuable source of novel pigments, including carotenoids (detailed further below) and proteins called bacteriorhodopsins.
  • 1.2K
  • 02 Sep 2022
Topic Review
Papaverine and Its Mechanism of Action
Papaverine has been proven to be a high-value opioid alkaloid in the field of therapeutics either in solitude or in combination with other metabolites/molecules. Pharmacological research has revealed that papaverine demonstrates a variety of biological activities, including activity against erectile dysfunction, postoperative vasospasms, and pulmonary vasoconstriction, as well as antiviral, cardioprotective, anti-inflammatory, anticancer, neuroprotective, and gestational actions.
  • 1.2K
  • 07 Apr 2023
Topic Review
Sirtuins
The sirtuin system consists of seven highly conserved regulatory enzymes responsible for metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is associated with the potential impact on life extension. 
  • 1.2K
  • 05 Jan 2023
Topic Review
the Major Facilitator Superfamily
Bacterial pathogens are serious causative agents of infectious disease. Such microorganisms are resistant to multiple antimicrobial agents, thereby compromising the therapeutic efficacy of treatment.  Multidrug-resistant pathogens harbor antimicrobial efflux pumps, many transporters of which are members of the extensive major facilitator superfamily of proteins. These bacterial multidrug efflux pumps are good molecular targets for modulation and possible inhibition.  This entry briefly discusses several current developments for drug efflux pump modulation. 
  • 1.2K
  • 27 Oct 2020
Topic Review
Aneuploidy
Aneuploidy is the presence of an abnormal number of chromosomes in a cell, for example a human cell having 45 or 47 chromosomes instead of the usual 46. It does not include a difference of one or more complete sets of chromosomes. A cell with any number of complete chromosome sets is called a euploid cell. An extra or missing chromosome is a common cause of some genetic disorders. Some cancer cells also have abnormal numbers of chromosomes. About 68% of human solid tumors are aneuploid. Aneuploidy originates during cell division when the chromosomes do not separate properly between the two cells (nondisjunction). Most cases of aneuploidy in the autosomes result in miscarriage, and the most common extra autosomal chromosomes among live births are 21, 18 and 13. Chromosome abnormalities are detected in 1 of 160 live human births. Autosomal aneuploidy is more dangerous than sex chromosome aneuploidy, as autosomal aneuploidy is almost always lethal to embryos that cease developing because of it.
  • 1.2K
  • 09 Nov 2022
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