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Topic Review
Terpenoid Lactones
Terpenoids with lactone moieties have been indicated to possess various biological activities. Certain terpenoid lactones exist in nature, in plants and animals, but they can also be obtained by chemical synthesis. Terpenoids possessing lactone moieties are known for their cytotoxic, anti-inflammatory, antimicrobial, anticancer, and antimalarial activities. 
  • 1.0K
  • 31 May 2021
Topic Review
Terpene Mini-Path for Terpenoids Bio-Production
Terpenoids constitute the largest class of natural compounds and are extremely valuable from an economic point of view due to their extended physicochemical properties and biological activities. An alternative to produce terpenoids is the use of biotechnological tools involving, for example, the construction of enzymatic cascades (cell-free synthesis) or a microbial bio-production thanks to metabolic engineering techniques. 
  • 635
  • 22 Dec 2021
Topic Review
Termite Microbial Symbiosis for Lignocellulosic Future Biorefinery
The hunt for renewable and alternative fuels has driven research towards the biological conversion of lignocellulosic biomass (LCB) into biofuels, including bioethanol and biohydrogen. Among the natural biomass utilization systems (NBUS), termites represent a unique and easy-to-access model system to study host–microbe interactions towards lignocellulose bioconversion/valorization. Termites have gained significant interest due to their highly efficient lignocellulolytic systems. The wood-feeding termites apply a unique and stepwise process for the hydrolysis of lignin, hemicellulose, and cellulose via biocatalytic processes; therefore, mimicking their digestive metabolism and physiochemical gut environments might lay the foundation for an innovative design of nature-inspired biotechnology.
  • 211
  • 05 Mar 2024
Topic Review
Terminal Osseous Dysplasia
Terminal osseous dysplasia is a disorder primarily involving skeletal abnormalities and certain skin changes. It is a member of a group of related conditions called otopalatodigital spectrum disorders, which also includes otopalatodigital syndrome type 1, otopalatodigital syndrome type 2, frontometaphyseal dysplasia, and Melnick-Needles syndrome. In general, these disorders involve hearing loss caused by malformations in tiny bones in the ears (ossicles), problems in the development of the roof of the mouth (palate), and skeletal abnormalities involving the fingers or toes (digits), although not every condition in the spectrum has all of these features.  
  • 504
  • 23 Dec 2020
Topic Review
TERF2
Telomeric repeat-binding factor 2 is a protein that is present at telomeres throughout the cell cycle. It is also known as TERF2, TRF2, and TRBF2, and is encoded in humans by the TERF2 gene. It is a component of the shelterin nucleoprotein complex and a second negative regulator of telomere length, playing a key role in the protective activity of telomeres. It was first reported in 1997 in the lab of Titia de Lange, where a DNA sequence similar, but not identical, to TERF1 was discovered, with respect to the Myb-domain. De Lange isolated the new Myb-containing protein sequence and called it TERF2.
  • 939
  • 03 Nov 2022
Topic Review
TERC Gene
Telomerase RNA component: The TERC gene provides instructions for making one component of an enzyme called telomerase. 
  • 556
  • 24 Dec 2020
Topic Review
Terahertz Radiation Modulates Neuronal Morphology and Dynamics Properties
Terahertz radiation falls within the spectrum of hydrogen bonding, molecular rotation, and vibration, as well as van der Waals forces, indicating that many biological macromolecules exhibit a strong absorption and resonance in this frequency band. Research has shown that the terahertz radiation of specific frequencies and energies can mediate changes in cellular morphology and function by exciting nonlinear resonance effects in proteins. However, current studies have mainly focused on the cellular level and lack systematic studies on multiple levels. Moreover, the mechanism and law of interaction between terahertz radiation and neurons are still unclear. 
  • 250
  • 21 Mar 2024
Topic Review
Tepotinib
Tepotinib (trade name Tepmetko) is a novel c-MET tyrosine kinase inhibitor that was recently approved in Japan for the treatment of patients with advanced non-small cell lung cancer (NSCLC) harboring a MET exon 14 skipping mutation.
  • 503
  • 23 Nov 2021
Topic Review
Tension wood of Catalpa bungei
Catalpa bungei is an economically important tree with high-quality wood and highly valuable to the study of wood formation. Tension wood (TW) is a special kind of wood and can represent an excellent model for studying the formation of xylem cell walls. There was no obvious gelatinous layer (G-layer) in the TW of C. bungei and that the secondary wall deposition in the TW was reduced compared with that in the opposite wood (OW) and normal wood (NW). The cellulose and pectin content and pectin methylation in the TW were lower than those in the OW and NW according to Raman spectroscopy, and many genes and proteins involved in the metabolic pathways of cellulose and pectin, such as galacturonosyltransferase (GAUT), polygalacturonase (PG), endoglucanase (CLE) and β-glucosidase (BGLU) genes, were significantly upregulated in TW. In addition, the MYB2 transcription factor may regulate the pectin degradation genes PG1 and PG3, and ARF, ERF, SBP and MYB1 may be the key transcription factors regulating the synthesis and decomposition of cellulose.
  • 880
  • 29 Oct 2020
Topic Review
TENG-Based Self-Powered Neuroprosthetics
TENG-Based Self-Powered Neuroprosthetics is a neuroprosthetic system using a triboelectric nanogenerator as the power source to generator the current pulses required for neural stimulations. The thin-film triboelectric nanogenerator can be attached onto the heart or buried under the skin to convert the mechanical energy from the movement of organs, such as heart beat, or the hand tapping onto the skin to electrical current pulses. This system is promising to realize a fully self-powered neural modulation with much reduced device complexity. 
  • 750
  • 10 Oct 2020
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