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Topic Review
TRPV1
Intracellular calcium (Ca2+) concentration ([Ca2+]i) is a key determinant of cell fate and is implicated in carcinogenesis. Membrane ion channels are structures through which ions enter or exit the cell, depending on the driving forces. The opening of transient receptor potential vanilloid 1 (TRPV1) ligand-gated ion channels facilitates transmembrane Ca2+ and Na+ entry, which modifies the delicate balance between apoptotic and proliferative signaling pathways. Proliferation is upregulated through two mechanisms: (1) ATP binding to the G-protein-coupled receptor P2Y2, commencing a kinase signaling cascade that activates the serine-threonine kinase Akt, and (2) the transactivation of the epidermal growth factor receptor (EGFR), leading to a series of protein signals that activate the extracellular signal-regulated kinases (ERK) 1/2. The TRPV1-apoptosis pathway involves Ca2+ influx and efflux between the cytosol, mitochondria, and endoplasmic reticulum (ER), the release of apoptosis-inducing factor (AIF) and cytochrome c from the mitochondria, caspase activation, and DNA fragmentation and condensation. While proliferative mechanisms are typically upregulated in cancerous tissues, shifting the balance to favor apoptosis could support anti-cancer therapies. TRPV1, through [Ca2+]i signaling, influences cancer cell fate; therefore, the modulation of the TRPV1-enforced proliferation–apoptosis balance is a promising avenue in developing anti-cancer therapies and overcoming cancer drug resistance. 
  • 1.3K
  • 09 Nov 2020
Topic Review
COVID-19 Mechanisms of Lung Damage
COVID-19 is a dangerous disease that  has been treated with dangerous and ineffective drugs like chloroquine and hydroxychloroquine. Nonsteroidal anti-inflammatory agents may also be dangerous in the disease due to embolism formation.  Safe and potentially effective alternative medicines are proposed.
  • 1.3K
  • 29 Oct 2020
Topic Review
Benzo[a]pyrene
Benzo[a]pyrene (B[a]P) is the main representative of polycyclic aromatic hydrocarbons (PAHs), and has been repeatedly found in the air, surface water, soil, and sediments.
  • 1.3K
  • 21 Jun 2022
Topic Review
Cytochrome c oxidase in Insects
Flight dispersal represents a key aspect of the evolutionary and ecological success of insects, allowing escape from predators, mating, and colonization of new niches. The huge energy demand posed by flight activity is essentially met by oxidative phosphorylation (OXPHOS) in flight muscle mitochondria. In insects, mitochondrial ATP supply and oxidant production are regulated by several factors, including the energy demand exerted by changes in adenylate balance. Indeed, adenylate directly regulates OXPHOS by targeting both chemiosmotic ATP production and the activities of specific mitochondrial enzymes. In several organisms, cytochrome c oxidase (COX) is regulated at transcriptional, post-translational, and allosteric levels, impacting mitochondrial energy metabolism, and redox balance.
  • 1.3K
  • 10 Jun 2021
Topic Review
Pathophysiology of Acute Myeloid Leukemia
Acute myeloid leukemia is a cancerous condition that affects hemopoietic stem cells or progenitors and is defined by the stopping of myeloid lineage development and abnormal proliferation.
  • 1.3K
  • 30 Mar 2023
Topic Review
Australian Raven
The Australian raven (Corvus coronoides) is a passerine bird in the genus Corvus native to much of southern and northeastern Australia. Measuring 46–53 centimetres (18–21 in) in length, it has all-black plumage, beak and mouth, as well as strong grey-black legs and feet. The upperparts are glossy, with a purple, blue, or green sheen, and its black feathers have grey bases. The Australian raven is distinguished from the Australian crow species by its throat hackles, which are prominent in adult birds. Older adult individuals have white irises, younger adults have white irises with an inner blue rim, while younger birds have dark brown irises until fifteen months of age, and hazel irises with an inner blue rim around each pupil until age two years and ten months. Nicholas Aylward Vigors and Thomas Horsfield described the Australian raven in 1827, its species name (coronoides) highlighting its similarity with the carrion crow (C. corone). Two subspecies are recognized, which differ slightly in calls and are quite divergent genetically. The preferred habitat is open woodland and transitional zones. It has adapted well to urban environments and is a common city bird in Sydney, Canberra, and Perth. An omnivorous and opportunistic feeder, it eats a wide variety of plant and animal material, as well as food waste from urban areas. In eastern Australia, its range is strongly correlated with the presence of sheep, and it has been blamed for killing lambs. However, this is very rare, and the raven most often scavenges for afterbirth and stillborn animals as well as newborn lamb faeces. The Australian raven is territorial, with pairs generally bonding for life. Breeding takes place between July and September, with almost no variation across its range. The nest is a bowl-shaped structure of sticks sited high in a tree, or occasionally in a man-made structure such as a windmill or other building. File:An audio recording of an Australian Raven (Corvus coronoides).wav
  • 1.3K
  • 21 Nov 2022
Topic Review
Sjögren’s Syndrome Pathogenic Molecular Pathways
Sjögren’s syndrome (SS) is a systemic autoimmune rheumatic disorder characterized by the lymphocytic infiltration of exocrine glands and the production of autoantibodies to self-antigens. The involvement of the exocrine glands drives the pathognomonic manifestations of dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia) that define sicca syndrome.
  • 1.3K
  • 01 Nov 2022
Topic Review
MEGDEL Syndrome
MEGDEL syndrome is an inherited disorder that affects multiple body systems. It is named for several of its features: 3-methylglutaconic aciduria (MEG), deafness (D), encephalopathy (E), and Leigh-like disease (L).
  • 1.3K
  • 23 Dec 2020
Topic Review
Hop
Hops is considered a short-day, temperate species, so the major challenge for the development of hop cultivation in Brazil, with high-yield capacity and with local typicity of bitterness and aroma, is the adaptation of cultivars to the photoperiod conditions in subtropical regions. 
  • 1.3K
  • 20 May 2022
Topic Review
Egyptian Honeybee
The Egyptian honeybee (Apis mellifera lamarckii) is one of the honeybee subspecies known for centuries since the ancient Egypt civilization. The subspecies of the Egyptian honeybee is distinguished by certain traits of appearance and behavior that were well-adapted to the environment and unique in a way that it is resistant to bee diseases, such as the Varroa disease. The subspecies is different than those found in Europe and is native to southern Egypt.
  • 1.3K
  • 21 Oct 2022
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